Oxford Textbook of Medicine 4-Volume Set

by Warrell, David A.; Cox, Timothy M.; Firth, John D.; Benz, Edward J.; Weatherall, David

• ISBN13: 9780192629227
• ISBN10: 0192629220
• Edition: 4th
• Format: Hardcover
• Copyright: 2003-03-20
• Publisher: Oxford University Press

Summary

The Oxford Textbook of Medicine provides all that any doctor needs to know to practice top-level internal medicine. It gives compreensive coverage of the epidemiology, aetiology, and mechanism of disease, as well as clear, unambiguous coverage of the diagnosis, practical management and prevention of the entire spectrum of medical disorders. There are major introductory sections on the scientific basis of disease; and in the system-based clinical sections genetic predisposition, pathophysiology, pathogenesis, molecular mechanisms, and cell biology are covered in depth for all significant medical syndromes. Clinical descriptions of diseases are clearly and memorably written, based on the experience and insight of the authors--many of whom are among the world's most distinguished medical scientists. Chapters are not only "evidence based" but also on clinical experience and a thorough survey of all the relevant literature. Throughout, the approach of OTM is humane and ethical and, at the same time, factual, reliable, honest(especially where knowledge is limited) and rigorously scientific. This is not just a textbook of "First World" medicine. It provides practical guidance for doctors working in a variety of medical setting the value of a logical clinical approach rather than immediate resort to expensive imaging and laboratory tests. Moore of the contributing authors than ever before are from outside Europe, including strong representation of North American medicine. The new editorial team has ensured that the OTM continues to reflect rapid changes in medical practice: there are new sections on intensive care, alcohol and drug abuse, clinical pharmacology and therapeutics, world health, clinical trials and evidence-based medicine, adolescent medicine, sports medicine, and emergency medicine; more than half the contributors are new for this edition; and most of the text has been heavily revised. The striking new page and cover design reflect the significant changes made in this new edition. The Textbook is illustrated by over 2000 two-color diagrams and many color Plates. The index is the most detailed and user-friendly of any major medical textbook: in an emergency, the reader can access information quickly- whether on the ward, in office or at home. Like its predecessors, OTM4 will be the trusted and ultimate reference in libraries, hospitals, doctors' consulting rooms, solicitors' offices, press offices, and primary care practices worldwide.

Table of Contents

Contributors	xxix
On being a patient
On being a patient	3	(4)
C. M. Clothier
Modern medicine: foundations, achievements, and limitations
Science in medicine: when, how, and what	7	(3)
W. F. Bynum
Scientific method and the art of healing	10	(4)
D. J. Weatherall
Medical ethics	14	(3)
Edmund D. Pellegrino
Daniel P. Sulmasy
The evidence base of modern medicine	17	(20)
Bringing the best evidence to the point of care	17	(4)
P. Glasziou
Evidence-based medicine	21	(3)
Alvan R. Feinstein
Large-scale randomized evidence: trials and overviews	24	(13)
R. Collins
R. Peto
R. Gray
S. Parish
Complementary and alternative medicine	37	(8)
E. Ernst
Global patterns of disease and medical practice
The Global Burden of Disease Study	45	(7)
C. J. L. Murray
A. D. Lopez
Human population size, environment, and health	52	(3)
A. J. McMichael
J. W. Powles
The pattern of care: hospital and community	55	(3)
Anthony Harrison
Preventive medicine	58	(6)
D. Mant
Health promotion	64	(4)
Keith Tones
Jackie Green
Screening	68	(6)
J. A. Muir Gray
The cost of health care	74	(7)
The cost of health care in Western countries	74	(2)
Joseph White
Health in a fragile future	76	(5)
Maurice King
Molecular mechanisms of disease
The genomic basis of medicine	81	(7)
Trevor Woodage
Francis S. Collins
The human genome sequence	88	(2)
Sydney Brenner
Molecular cell biology	90	(18)
William M. F. Lee
Newman M. Yeilding
Cytokines: interleukin-1 and tumour necrosis factor in inflammation	108	(4)
Charles A. Dinarello
Ion channels and disease	112	(7)
Frances M. Ashcroft
Apoptosis in health and disease	119	(12)
Andrew H. Wyllie
Mark J. Arends
Immunological mechanisms
Principles of immunology	131	(14)
A. J. McMichael
Allergy	145	(5)
L. M. Lichtenstein
Autoimmunity	150	(10)
Antony Rosen
Complement	160	(7)
Mark J. Walport
Innate immune system	167	(5)
D. T. Fearon
M. Allison
Immunodeficiency	172	(11)
A. D. B. Webster
Principles of transplantation immunology	183	(10)
Kathryn J. Wood
Principles of clinical oncology
Epidemiology of cancer	193	(26)
R. Doll
R. Peto
The nature and development of cancer	219	(10)
Andrew Coop
Matthew J. Ellis
The genetics of inherited cancers	229	(9)
Andrew Coop
Matthew J. Ellis
Tumour metastasis	238	(3)
V. Urquidi
D. Tarin
Tumour immunology	241	(7)
P. C. L. Beverley
Cancer: clinical features and management	248	(12)
R. L. Souhami
Cancer chemotherapy and radiation therapy	260	(9)
Michael L. Grossbard
Bruce A. Chabner
Infection
The clinical approach to the patient with suspected infection	269	(2)
David Rubenstein
Fever of unknown origin	271	(5)
David T. Durack
Biology of pathogenic micro-organisms	276	(4)
T. H. Pennington
The host response to infection	280	(9)
Leszek K. Borysiewicz
Physiological changes in infected patients	289	(4)
P. A. Murphy
Antimicrobial chemotherapy	293	(15)
R. G. Finch
Immunization	308	(4)
D. Goldblatt
M. Ramsay
Travel and expedition medicine	312	(5)
C. P. Conlon
D. A. Warrell
Nosocomial infections	317	(4)
I. C. J. W. Bowler
Viruses	321	(132)
Respiratory tract viruses	321	(6)
Malik Peiris
Herpesviruses (excluding Epstein--Barr virus)	327	(14)
J. G. P. Sissons
The Epstein--Barr virus	341	(4)
M. A. Epstein
Dorothy H. Crawford
Poxviruses	345	(4)
Geoffrey L. Smith
Mumps: epidemic parotitis	349	(2)
B. K. Rima
Measles	351	(6)
H. C. Whittle
P. Aaby
Nipah and Hendra viruses	357	(1)
James G. Olson
Enterovirus infections	358	(6)
Ulrich Desselberger
Philip Minor
Virus infections causing diarrhoea and vomiting	364	(3)
Ulrich Desselberger
Rhabdoviruses: rabies and rabies-related viruses	367	(9)
M. J. Warrell
D. A. Warrell
Colorado tick fever and other arthropod-borne reoviruses	376	(1)
M. J. Warrell
D. A. Warrell
Alphaviruses	377	(3)
L. R. Petersen
D. J. Gubler
Rubella	380	(2)
P. A. Tookey
S. Logan
Flaviviruses	382	(7)
L. R. Petersen
D. J. Gubler
Bunyaviridae	389	(7)
J. W. LeDuc
J. S. Porterfield
Arenaviruses	396	(8)
Susan Fisher-Hoch
Joseph McCormick
Filoviruses	404	(2)
Susan Fisher-Hoch
Joseph McCormick
Papovaviruses	406	(6)
K. V. Shah
Parvovirus B19	412	(2)
B. J. Cohen
Hepatitis viruses (including TTV)	414	(5)
N. V. Naoumov
Hepatitis C virus	419	(4)
D. L. Thomas
HIV and AIDS	423	(19)
G. A. Luzzi
T. E. A. Peto
R. A. Weiss
C. P. Conlon
HIV in the developing world	442	(5)
Charles F. Gilks
HTLV-I and II and associated diseases	447	(2)
C. R. M. Bangham
M. Osame
S. Nightingale
Viruses and cancer	449	(1)
R. A. Weiss
Orf	450	(1)
N. Jones
Molluscum contagiosum	451	(2)
N. Jones
Bacteria	453	(236)
Diphtheria	453	(3)
Delia B. Bethell
Tran Tin Hien
Streptococci and enterococci	456	(5)
S. J. Eykyn
Pneumococcal diseases	461	(9)
Keith P. Klugman
Brian M. Greenwood
Staphylococci	470	(8)
S. J. Eykyn
Meningococcal infections	478	(8)
P. Brandtzaeg
Neisseria gonorrhoeae	486	(3)
D. Barlow
C. Ison
Enterobacteria, campylobacter, and miscellaneous food- poisoning bacteria	489	(14)
G. T. Keusch
M. B. Skirrow
Typhoid and paratyphoid fevers	503	(4)
J. Richens
C. Parry
Intracellular Klebsiella infections	507	(3)
J. Richens
Anaerobic bacteria	510	(5)
S. J. Eykyn
Cholera	515	(6)
Michael L. Bennish
Haemophilus influenzae	521	(2)
E. R. Moxon
Haemophilus ducreyi and chancroid	523	(2)
Allan R. Ronald
Bordetella	525	(2)
Calvin C. Linnemann, Jr
Melioidosis and glanders	527	(3)
D. A. B. Dance
Plague	530	(3)
T. Butler
Yersinia, Pasteurella, and Francisella	533	(5)
David Lalloo
Anthrax	538	(4)
Thira Sirisanthana
Brucellosis	542	(3)
M. Monir Madkour
Tetanus	545	(6)
F. E. Udwadia
Botulism, gas gangrene, and clostridial gastrointestinal infections	551	(5)
H. E. Larson
Tuberculosis	556	(16)
Richard E. Chaisson
Jean Nachega
Disease caused by environmental mycobacteria	572	(3)
J. M. Grange
P. D. O. Davies
Leprosy (Hansen's disease)	575	(8)
Diana N. J. Lockwood
Buruli ulcer: Mycobacterium ulcerans infection	583	(2)
Wayne M. Meyers
Francoise Portaels
Actinomycosis	585	(3)
K. P. Schaal
Nocardiosis	588	(2)
R. J. Hay
Rat-bite fevers	590	(2)
D. A. Warrell
Lyme borreliosis	592	(3)
John Nowakowski
Robert B. Nadelman
Gary P. Wormser
Other borrelia infections	595	(5)
D. A. Warrell
Leptospirosis	600	(4)
George Watt
Non-venereal treponematoses: yaws, endemic syphilis (bejel), and pinta	604	(3)
P. L. Perine
D. A. Warrell
Syphilis	607	(11)
D. J. M. Wright
S. E. Jones
Listeriosis	618	(2)
P. J. Wilkinson
Legionellosis and legionnaires' disease	620	(3)
J. B. Kurtz
J. T. Macfarlane
Rickettsial diseases including ehrlichiosis	623	(6)
D. H. Walker
Scrub typhus	629	(3)
George Watt
Coxiella burnetii infections (Q fever)	632	(2)
T. J. Marrie
Bartonelloses, excluding Bartonella bacilliformis infections	634	(4)
James G. Olson
Bartonella bacilliformis infection	638	(3)
A. Llanos Cuentas
Chlamydial infections including lymphogranuloma venerum	641	(8)
D. Taylor-Robinson
D. C. W. Mabey
Mycoplasmas	649	(9)
D. Taylor-Robinson
Newly identified and lesser known bacteria	658	(31)
J. Paul
Fungal infections (mycoses)	689	(25)
Fungal infections	689	(14)
R. J. Hay
Cryptococcosis	703	(1)
William G. Powderly
Coccidioidomycosis	704	(1)
John R. Graybill
Paracoccidioidomycosis	705	(5)
M. A. S. Yasuda
Pneumocystis carinii	710	(2)
Robert F. Miller
Ann E. Wakefield
Infection due to Penicillium marneffei	712	(2)
Thira Sirisanthana
Protozoa	714	(71)
Amoebic infections	714	(7)
R. Knight
Malaria	721	(27)
D. J. Bradley
D. A. Warrell
Babesia	748	(1)
P. Brasseur
Toxoplasmosis	749	(4)
J. Couvreur
Ph. Thulliez
Cryptosporidium and cryptosporidiosis	753	(4)
D. P. Casemore
D. A. Warrell
Cyclospora	757	(1)
D. P. Casemore
Sarcocystosis	758	(1)
V. Zaman
Giardiasis, balantidiasis, isosporiasis, and microsporidiosis	759	(6)
Martin F. Heyworth
Blastocystis hominis infection	765	(1)
R. Knight
Human African trypanosomiasis	766	(6)
August Stich
Chagas' disease	772	(5)
M. A. Miles
Leishmaniasis	777	(6)
A. D. M. Bryceson
Trichomoniasis	783	(2)
J. P. Ackers
Nematodes (roundworms)	785	(33)
Cutaneous filariasis	785	(5)
G. M. Burnham
Lymphatic filariasis	790	(5)
R. Knight
Guinea-worm disease: dracunculiasis	795	(2)
R. Knight
Strongyloidiasis, hookworm, and other gut strongyloid nematodes	797	(4)
R. Knight
Nematode infections of lesser importance	801	(4)
David I. Grove
Other gut nematodes	805	(6)
V. Zaman
Toxocariasis and visceral larva migrans	811	(2)
V. Zaman
Angiostrongyliasis	813	(2)
R. Knight
Gnathostomiasis	815	(3)
Pravan Suntharasamai
Cestodes (tapeworms)	818	(12)
Cystic hydatid disease (Echinococcus granulosus)	818	(2)
Armando E. Gonzalez
Pedro L. Moro
Hector H. Garcia
Gut cestodes	820	(4)
R. Knight
Cysticercosis	824	(4)
Hector H. Garcia
Robert H. Gilman
Pseudophyllidean tapeworms: diphyllobothriasis and sparganosis	828	(2)
Seung-Yull Cho
Trematodes (flukes)	830	(18)
Schistosomiasis	830	(7)
D. W. Dunne
B. J. Vennervald
Liver fluke infections	837	(3)
David I. Grove
Lung flukes (paragonimiasis)	840	(3)
Sirivan Vanijanonta
Intestinal trematode infections	843	(5)
David I. Grove
Non-venomous arthropods	848	(9)
J. Paul
Pentostomiasis (porocephalosis)	857	(3)
D. A. Warrell
Chronic fatigue syndrome (postviral fatigue syndrome, neurasthenia, and myalgic encephalomyelitis)	860	(4)
Michael Sharpe
Infection in the immunocompromised host	864	(9)
J. Cohen
Chemical and physical injuries and environmental factors and disease
Poisoning by drugs and chemicals	873	(50)
A. T. Proudfoot
J. A. Vale
Injuries, envenoming, poisoning, and allergic reactions caused by animals	923	(24)
D. A. Warrell
Poisonous plants and fungi	947	(5)
M. R. Cooper
A. W. Johnson
H. Persson
Occupational and environmental health and safety	952	(14)
Occupational and environmental health and safety	952	(9)
J. M. Harrington
K. Gardiner
I. S. Foulds
T. C. Aw
E. L. Baker
A. Spurgeon
Occupational safety	961	(5)
Richard T. Booth
Environmental diseases	966	(37)
Environmental extremes---heat	966	(1)
M. A. Stroud
Environmental extremes---cold	967	(2)
M. A. Stroud
Drowning	969	(2)
Peter J. Fenner
Diseases of high terrestrial altitudes	971	(5)
D. Rennie
Aerospace medicine	976	(6)
D. M. Denison
M. Bagshaw
Diving medicine	982	(5)
D. M. Denison
T. J. R. Francis
Lightning and electrical injuries	987	(2)
Chris Andrews
Podoconiosis	989	(2)
S. M. Evans
J. J. Powell
R. P. H. Thompson
Radiation	991	(3)
J. R. Harrison
Noise	994	(2)
R. McCaig
T. C. Aw
Vibration	996	(1)
T. C. Aw
R. McCaig
Disasters: earthquakes, volcanic eruptions, hurricanes, and floods	997	(6)
Peter J. Baxter
Principles of clinical pharmacology and drug therapy
Principles of clinical pharmacology and drug therapy	1003	(24)
Andrew Herxheimer
Nutrition
Diseases of overnourished societies and the need for dietary change	1027	(10)
J. I. Mann
A. S. Truswell
Nutrition: biochemical background	1037	(7)
Keith N. Frayn
Vitamins and trace elements	1044	(10)
M. Eastwood
Severe malnutrition	1054	(8)
Alan A. Jackson
Obesity	1062	(11)
Peter G. Kopelman
Stephen O'Rahilly
Special nutritional problems and the use of enteral and parenteral nutrition	1073
M. Elia
Index
Contributors	xxix
Metabolic disorders
The inborn errors of metabolism: general aspects	3	(6)
Richard W. E. Watts
Inborn errors of amino acid and organic acid metabolism	9	(23)
P. J. Lee
D. P. Brenton
Disorders of carbohydrate metabolism	32	(17)
Glycogen storage diseases	32	(7)
T. M. Cox
Inborn errors of fructose metabolism	39	(5)
T. M. Cox
Disorders of galactose, pentose, and pyruvate metabolism	44	(5)
T. M. Cox
Disorders of purine and pyrimidine metabolism	49	(12)
Richard W. E. Watts
The porphyrias	61	(13)
T. M. Cox
Lipid and lipoprotein disorders	74	(17)
P. N. Durrington
Trace metal disorders	91	(19)
Hereditary haemochromatosis	91	(11)
T. M. Cox
Wilson's disease, Menke's disease: inherited disorders of copper metabolism	102	(8)
C. A. Seymour
Lysosomal storage diseases	110	(14)
T. M. Cox
Peroxisomal diseases	124	(10)
Ronald J. A. Wanders
Ruud B. H. Schutgens
Disorders of oxalate metabolism	134	(5)
Richard W. E. Watts
C. J. Danpure
Disturbances of acid-base homeostasis	139	(11)
R. D. Cohen
H. F. Woods
Amyloid, familial Mediterranean fever, and acute phase response	150	(24)
The acute phase response and C-reactive protein	150	(6)
M. B. Pepys
Metabolic responses to accidental and surgical injury	156	(2)
Roderick A. Little
Familial Mediterranean fever and other inherited periodic fever syndromes	158	(4)
P. N. Hawkins
D. R. Booth
Amyloidosis	162	(12)
M. B. Pepys
P. N. Hawkins
α1-Antitrypsin deficiency and the serpinopathies	174	(7)
David A. Lomas
Endocrine disorders
Principles of hormone action	181	(10)
Mark Gurnell
Jacky Burrin
V. Krishna K. Chatterjee
Disorders of the anterior pituitary	191	(13)
Paul J. Jenkins
Michael Besser
Disorders of the posterior pituitary	204	(5)
John Newell-Price
Michael Besser
The thyroid gland and disorders of thyroid function	209	(16)
Anthony P. Weetman
Thyroid cancer	225	(5)
Anthony P. Weetman
Parathyroid disorders and diseases altering calcium metabolism	230	(12)
R. V. Thakker
The adrenal	242	(24)
Disorders of the adrenal cortex	242	(19)
P. M. Stewart
Congenital adrenal hyperplasia	261	(5)
I. A. Hughes
The reproductive system	266	(30)
Ovarian disorders	266	(8)
H. S. Jacobs
Disorders of male reproduction	274	(11)
F. C. W. Wu
The breast	285	(2)
H. S. Jacobs
Sexual dysfunction	287	(9)
Raymond C. Rosen
Irwin Goldstein
Disorders of development	296	(13)
Normal and abnormal sexual differentiation	296	(5)
M. O. Savage
Normal growth and its disorders	301	(5)
M. A. Preece
Puberty	306	(3)
R. J. M. Ross
M. O. Savage
Non-diabetic pancreatic endocrine disorders and multiple endocrine neoplasia	309	(8)
P. J. Hammond
S. R. Bloom
Disorders of glucose homeostasis	317	(53)
Diabetes	317	(43)
Gareth Williams
The genetics of diabetes	360	(2)
J. A. Todd
Hypoglycaemia	362	(8)
V. Marks
Hormonal manifestations of non-endocrine disease	370	(8)
H. E. Turner
J. A. H. Wass
The pineal gland and melatonin	378	(5)
T. M. Cox
Medical disorders in pregnancy
Physiological changes of normal pregnancy	383	(3)
D. J. Williams
Nutrition in pregnancy	386	(4)
D. J. Williams
Medical management of normal pregnancy	390	(6)
D. J. Williams
Hypertension in pregnancy	396	(8)
C. W. G. Redman
Renal disease in pregnancy	404	(4)
J. Firth
Heart disease in pregnancy	408	(5)
J. C. Forfar
Thromboembolism in pregnancy	413	(4)
M. de Swiet
Chest diseases in pregnancy	417	(4)
M. de Swiet
Liver and gastrointestinal diseases during pregnancy	421	(6)
A. E. S. Gimson
Diabetes in pregnancy	427	(5)
Michael D. J. Gillmer
Endocrine disease in pregnancy	432	(4)
John H. Lazarus
Neurological disease in pregnancy	436	(4)
G. G. Lennox
The skin in pregnancy	440	(3)
F. Wojnarowska
Autoimmune rheumatic disorders and vasculitis in pregnancy	443	(6)
Catherine Nelson-Piercy
Munther A. Khamashta
Infections in pregnancy	449	(7)
Mark Herbert
Lawrence Impey
Blood disorders in pregnancy	456	(8)
E. A. Letsky
Malignant disease in pregnancy	464	(4)
Robin A. F. Crawford
Prescribing in pregnancy	468	(4)
P. C. Rubin
Benefits and risks of oral contraceptives	472	(4)
M. P. Vessey
Benefits and risks of hormone replacement therapy	476	(7)
J. C. Stevenson
Gastroenterology
Introduction to gastroenterology	483	(8)
Graham Neale
Anatomy and clinical physiology	484	(1)
Structure and function of the gut	484	(2)
D. G. Thompson
Symptomatology of gastrointestinal disease	486	(5)
Graham Neale
Methods for investigation of gastrointestinal disease	491	(17)
Colonoscopy and flexible sigmoidoscopy	491	(3)
Christopher B. Williams
Brian P. Saunders
Upper gastrointestinal endoscopy	494	(4)
Adrian R. W. Hatfield
Radiology of the gastrointestinal tract	498	(5)
Alan Freeman
Investigation of gastrointestinal function	503	(5)
Julian R. F. Walters
Major gastrointestinal emergencies	508	(7)
The acute abdomen	508	(3)
Julian Britton
Gastrointestinal bleeding	511	(4)
T. A. Rockall
T. Northfield
Immune disorders of the gastrointestinal tract	515	(11)
M. R. Haeney
The mouth and salivary glands	526	(19)
T. Lehner
Diseases of the oesophagus	545	(13)
John Dent
Richard H. Holloway
Peptic ulcer diseases	558	(11)
John Calam
Hormones and the gastrointestinal tract	569	(8)
P. J. Hammond
S. R. Bloom
A. E. Bishop
J. M. Polak
Malabsorption	577	(27)
Differential diagnosis and investigation of malabsorption	577	(3)
Julian R. F. Walters
Small bowel bacterial overgrowth	580	(5)
P. P. Toskes
Coeliac disease	585	(4)
D. P. Jewell
Gastrointestinal lymphoma	589	(4)
P. G. Isaacson
Disaccharidase deficiency	593	(3)
T. M. Cox
Whipple's disease	596	(2)
H. J. F. Hodgson
Effects of massive small bowel resection	598	(2)
R. J. Playford
Malabsorption syndromes in the tropics	600	(4)
V. I. Mathan
Crohn's disease	604	(8)
D. P. Jewell
Ulcerative colitis	612	(9)
D. P. Jewell
Functional bowel disorders and irritable bowel syndrome	621	(4)
D. G. Thompson
Colonic diverticular disease	625	(4)
N. J. McC. Mortensen
M. G. W. Kettlewell
Congenital abnormalities of the gastrointestinal tract	629	(8)
V. M. Wright
J. A. Walker-Smith
Tumours of the gastrointestinal tract	637	(15)
A. F. Markham
I. C. Talbot
C. B. Williams
Vascular and collagen disorders	652	(6)
Graham Neale
Gastrointestinal infections	658	(9)
Davidson H. Hamer
Sherwood L. Gorbach
Liver, pancreas, and biliary tree	667	(30)
The structure and function of the liver, biliary tract, and pancreas	667	(7)
A. E. S. Gimson
Computed tomography and magnetic resonance imaging of the liver and pancreas	674	(5)
C. S. Ng
D. J. Lomas
A. K. Dixon
Diseases of the pancreas	679	(1)
Acute pancreatitis	679	(8)
C. W. Imrie
Chronic pancreatitis	687	(6)
P. P. Toskes
Tumours of the pancreas	693	(4)
Julian Britton
Disease of the gallbladder and biliary tree	697	(17)
Congenital disorders of the liver, biliary tract, and pancreas	697	(3)
J. A. Summerfield
Diseases of the gallbladder and biliary tree	700	(8)
J. A. Summerfield
Jaundice	708	(6)
R. P. H. Thompson
Hepatitis and autoimmune liver disease	714	(17)
Viral hepatitis---clinical aspects	714	(6)
H. J. F. Hodgson
Autoimmune liver disease	720	(1)
Autoimmune hepatitis	720	(3)
H. J. F. Hodgson
Primary biliary cirrhosis	723	(4)
M. F. Bassendine
Primary sclerosing cholangitis	727	(4)
R. W. Chapman
Other disorders of the liver	731	(47)
Alcoholic liver disease and non-alcoholic steatosis hepatitis	731	(2)
O. F. W. James
Cirrhosis, portal hypertension, and ascites	733	(8)
Kevin Moore
Hepatocellular failure	741	(10)
E. Anthony Jones
Liver transplantation	751	(5)
Graeme J. M. Alexander
M. Allison
Primary and secondary liver tumours	756	(4)
Iain M. Murray-Lyon
Hepatic granulomas	760	(4)
C. W. N. Spearman
P. de la Motte Hall
S. J. Saunders
Drugs and liver damage	764	(7)
J. Neuberger
The liver in systemic disease	771	(7)
J. Neuberger
Miscellaneous disorders of the gastrointestinal tract and liver	778	(9)
D. P. Jewell
Cardiovascular medicine
Cardiovascular biology, atherosclerosis, and thrombosis	787	(42)
The blood vessels	787	(1)
Introduction	787	(1)
Peter L. Weissberg
Vascular endothelium, its physiology and pathophysiology	788	(7)
P. Vallance
Vascular smooth muscle cells	795	(2)
Peter L. Weissberg
Atherosclerosis and thrombosis	797	(1)
The pathogenesis of atherosclerosis	797	(5)
R. P. Naoumova
J. Scott
The haemostatic system in arterial disease	802	(7)
T. W. Meade
P. K. MacCallum
G. J. Miller
The heart	809	(1)
Physical considerations: biochemistry and cellular physiology of heart muscle	809	(11)
P. H. Sugden
N. J. Severs
K. T. MacLeod
P. A. Poole-Wilson
Clinical physiology of the normal heart	820	(9)
D. E. L. Wilcken
Clinical presentation of heart disease	829	(25)
Chest pain	829	(3)
J. R. Hampton
The syndrome of heart failure	832	(13)
Andrew J. S. Coats
Syncope and palpitation	845	(4)
A. C. Rankin
S. M. Cobbe
Physical examination of the cardiovascular system	849	(5)
J. R. Hampton
Clinical investigation	854	(52)
Chest radiography in heart disease	854	(5)
M. B. Rubens
Electrocardiography	859	(20)
D. J. Rowlands
Echocardiography	879	(5)
A. P. Banning
Nuclear techniques	884	(6)
H. J. Testa
D. J. Rowlands
Cardiovascular magnetic resonance and computed X-ray tomography	890	(7)
S. Richard Underwood
Raad H. Mohiaddin
M. B. Rubens
Cardiac catheterization and angiography	897	(9)
Edward D. Folland
Ischaemic heart disease	906	(53)
Epidemiology	906	(1)
Influences acting in utero and early childhood	906	(3)
D. J. P. Barker
The epidemiology of ischaemic heart disease	909	(11)
A. R. Ness
G. Davey Smith
Pathophysiology and clinical features	920	(1)
The pathophysiology of acute coronary syndromes	920	(4)
Peter L. Weissberg
Management of stable angina	924	(2)
L. M. Shapiro
Management of acute coronary syndromes: unstable angina and myocardial infarction	926	(19)
Keith A. A. Fox
Percutaneous interventional cardiac procedures	945	(5)
Edward D. Folland
Coronary artery bypass grafting	950	(3)
A. J. Ritchie
L. M. Shapiro
The impact of coronary heart disease on life and work	953	(6)
M. C. Petch
Treatment of heart failure	959	(16)
Pharmacological management of heart failure	959	(9)
J. K. Aronson
Therapeutic anticoagulation in atrial fibrillation and heart failure	968	(1)
David Keeling
Cardiac rehabilitation	968	(2)
Andrew J. S. Coats
Cardiac transplantation and mechanical circulatory support	970	(5)
John H. Dark
Cardiac arrhythmias	975	(23)
S. M. Cobbe
A. C. Rankin
Valve disease	998	(19)
D. G. Gibson
Diseases of heart muscle	1017	(25)
Myocarditis	1017	(4)
Jay W. Mason
The cardiomyopathies: hypertrophic, dilated, restrictive, and right ventricular	1021	(14)
William J. McKenna
Specific heart muscle disorders	1035	(7)
William J. McKenna
Pericardial disease	1042	(8)
D. G. Gibson
Cardiac involvement in infectious disease	1050	(21)
Acute rheumatic fever	1050	(6)
Jonathan R. Carapetis
Infective endocarditis	1056	(10)
W. Littler
S. J. Eykyn
Cardiovascular syphilis	1066	(1)
B. Gribbin
I. Byren
Cardiac disease in HIV infection	1067	(4)
N. Boon
Tumours of the heart	1071	(3)
Cardiac myxoma	1071	(2)
Thomas A. Traill
Other tumours of the heart	1073	(1)
Thomas A. Traill
Cardiac involvement in genetic disease	1074	(4)
Thomas A. Traill
Congenital heart disease in adolescents and adults	1078	(27)
S. A. Thorne
P. J. Oldershaw
Disorders of the arteries	1105	(16)
Thoracic aortic dissection	1105	(4)
B. Gribbin
A. P. Banning
Peripheral arterial disease	1109	(5)
Janet Powell
Alun Davies
Cholesterol embolism	1114	(3)
C. R. K. Dudley
Takayasu arteritis	1117	(4)
Fujio Numano
The pulmonary circulation	1121	(32)
The pulmonary circulation and its influence on gas exchange	1121	(2)
Tim Higenbottam
Eric Demoncheaux
Tom Siddons
Disorders of the pulmonary circulation	1123	(1)
Primary pulmonary hypertension	1123	(7)
Tim Higenbottam
Helen Marriott
Pulmonary oedema	1130	(7)
J. S. Prichard
J. Firth
Venous thromboembolism	1137	(1)
Deep venous thrombosis and pulmonary embolism	1137	(12)
Paul D. Stein
J. Firth
Therapeutic anticoagulation in deep venous thrombosis and pulmonary embolism	1149	(4)
David Keeling
Hypertenstion	1153	(49)
Essential hypertension	1153	(1)
Prevalence, epidemiology, and pathophysiology of hypertension	1153	(7)
C. G. Isles
Genetics of hypertension	1160	(4)
N. J. Samani
Essential hypertension	1164	(15)
J. Swales
Secondary hypertension	1179	(1)
Hypertension---indications for investigation	1179	(3)
Lawrence E. Ramsay
Renal and renovascular hypertension	1182	(4)
Lawrence E. Ramsay
Primary hyperaldosteronism (Conn's syndrome)	1186	(2)
M. J. Brown
Phaeochromocytoma	1188	(4)
M. J. Brown
Aortic coarctation	1192	(1)
Lawrence E. Ramsay
Other rare causes of hypertension	1193	(1)
Lawrence E. Ramsay
Hypertensive emergencies and urgencies	1194	(8)
Gregory Y. H. Lip
D. Gareth Beevers
Lymphoedema	1202	(7)
Peter S. Mortimer
Idiopathic oedema of women	1209	(4)
J. Firth
Critical care medicine
The clinical approach to the patient who is very ill	1213	(6)
J. Firth
The circulation and circulatory support of the critically ill	1219	(9)
David F. Treacher
Cardiac arrest	1228	(5)
C. A. Eynon
Anaphylaxis	1233	(5)
Anthony F. T. Brown
Respiratory support of the critically ill	1238	(12)
Pathophysiology and pathogenesis of acute respiratory distress syndrome	1238	(4)
C. Haslett
The management of respiratory failure	1242	(8)
Christopher S. Garrard
Other medical issues on the ICU	1250	(17)
Sedation and analgesia in the critically ill	1250	(3)
G. R. Park
B. Ward
Management of raised intracranial pressure	1253	(4)
David K. Menon
Brainstem death and organ donation	1257	(3)
M. J. Lindop
The patient without hope	1260	(7)
M. J. Lindop
Respiratory medicine
Structure and function	1267	(16)
The upper respiratory tract	1267	(3)
J. R. Stradling
Structure and function of the airways and alveoli	1270	(7)
Peter D. Wagner
`First line' defence mechanisms of the lung	1277	(6)
C. Haslett
The clinical presentation of chest diseases	1283	(9)
D. J. Lane
Clinical investigation of respiratory disease	1292	(32)
Thoracic imaging	1292	(12)
Susan Copley
David M. Hansell
Respiratory function tests	1304	(7)
G. J. Gibson
Microbiological methods in the diagnosis of respiratory infections	1311	(4)
Robert Wilson
Diagnostic bronchoscopy, thoracoscopy, and tissue biopsy	1315	(9)
M. F. Muers
Allergic rhinitis and asthma	1324	(31)
Asthma: genetic effects	1324	(1)
J. M. Hopkin
Allergic rhinitis (`hay fever')	1325	(4)
S. R. Durham
Basic mechanisms and pathophysiology of asthma	1329	(4)
Tak H. Lee
Asthma	1333	(17)
A. J. Newman Taylor
Occupational asthma	1350	(5)
A. J. Newman Taylor
Respiratory infection	1355	(22)
Upper respiratory tract infections	1355	(2)
P. Little
Infection of the lung	1357	(1)
Pneumonia---normal host	1357	(11)
John G. Bartlett
Nosocomial pneumonia	1368	(3)
John G. Bartlett
Pulmonary complications of HIV infection	1371	(6)
Mark J. Rosen
Chronic obstructive pulmonary disease	1377	(20)
William MacNee
Chronic respiratory failure	1397	(7)
P. M. A. Calverley
The upper respiratory tract	1404	(17)
Upper airways obstruction	1404	(5)
J. R. Stradling
Sleep-related disorders of breathing	1409	(12)
J. R. Stradling
Bronchiectasis	1421	(7)
D. Bilton
Cystic fibrosis	1428	(11)
Duncan Geddes
Andy Bush
Diffuse parenchymal lung disease	1439	(74)
Diffuse parenchymal lung disease: an introduction	1439	(7)
R. M. du Bois
Cryptogenic fibrosing alveolitis	1446	(6)
R. M. du Bois
Bronchiolitis obliterans and organizing pneumonia	1452	(3)
R. M. du Bois
The lungs and rheumatological diseases	1455	(5)
R. M. du Bois
A. K. Wells
The lung in vasculitis	1460	(4)
R. M. du Bois
Sarcoidosis	1464	(8)
Robert P. Baughman
Elyse E. Lower
Pneumoconioses	1472	(8)
A. Seaton
Pulmonary haemorrhagic disorders	1480	(2)
D. J. Hendrick
G. P. Spickett
Eosinophilic pneumonia	1482	(2)
D. J. Hendrick
G. P. Spickett
Lymphocytic infiltrations of the lung	1484	(3)
D. J. Hendrick
Extrinsic allergic alveolitis	1487	(9)
D. J. Hendrick
G. P. Spickett
Eosinophilic granuloma of the lung and pulmonary lymphangiomyomatosis	1496	(2)
D. J. Hendrick
Pulmonary alveolar proteinosis	1498	(2)
D. J. Hendrick
Pulmonary amyloidosis	1500	(2)
D. J. Hendrick
Lipoid (lipid) pneumonia	1502	(1)
D. J. Hendrick
Pulmonary alveolar microlithiasis	1503	(1)
D. J. Hendrick
Toxic gases and fumes	1504	(2)
D. J. Hendrick
Radiation pneumonitis	1506	(1)
D. J. Hendrick
Drug-induced lung disease	1507	(6)
D. J. Hendrick
G. P. Spickett
Pleural disease	1513	(10)
M. K. Benson
Disorders of the thoracic cage and diaphragm	1523	(7)
J. M. Shneerson
Neoplastic disorders	1530	(19)
Lung cancer	1530	(12)
S. G. Spiro
Pulmonary metastases	1542	(1)
S. G. Spiro
Pleural tumours	1543	(2)
M. K. Benson
Mediastinal tumours and cysts	1545	(4)
M. K. Benson
The genetics of lung diseases	1549	(3)
J. M. Hopkin
Lung and heart--lung transplantation	1552
K. McNeil
Index
Contributors	xxix
Rheumatology
Joints and connective tissue: introduction	3	(4)
Jonathan C. W. Edwards
Clinical presentation and diagnosis of rheumatic disease	7	(5)
Anthony S. Russell
Robert Ferrari
Clinical investigation	12	(9)
Michael Doherty
Peter Lanyon
Back pain and regional disorders	21	(6)
Simon Carette
Rheumatoid arthritis	27	(16)
R. N. Maini
Spondyloarthritides and related arthritides	43	(11)
J. Braun
J. Sieper
Rheumatic disorders associated with infection	54	(8)
Pyogenic arthritis	54	(3)
Anthony R. Berendt
Reactive arthritis	57	(5)
J. S. H. Gaston
Osteoarthritis	62	(7)
Paul H. Brion
Kenneth C. Kalunian
Crystal-related arthropathies	69	(9)
S. C. O'Reilly
M. Doherty
Autoimmune rheumatic disorders and vasculitides	78	(42)
Autoimmune rheumatic disorders and vasculitis	78	(2)
I. P. Giles
D. A. Isenberg
Systemic lupus erythematosus and related disorders	80	(10)
Anisur Rahman
David Isenberg
Systemic sclerosis	90	(13)
Carol M. Black
Christopher P. Denton
Polymyalgia rheumatica and giant-cell arteritis	103	(3)
Alastair G. Mowat
Behcet's disease	106	(4)
T. Lehner
Sjogren's syndrome	110	(3)
Patrick J. W. Venables
Polymyositis and dermatomyositis	113	(3)
John H. Stone
David B. Hellmann
Kawasaki syndrome	116	(4)
Tomisaku Kawasaki
Miscellaneous conditions presenting to the rheumatologist	120	(11)
D. O'Gradaigh
B. Hazleman
Diseases of the skeleton
Disorders of the skeleton	131	(36)
R. Smith
Inherited defects of connective tissue: Ehlers--Danlos syndrome, Marfan's syndrome, and pseudoxanthoma elasticum	167	(12)
F. M. Pope
Osteomyelitis	179	(6)
Anthony R. Berendt
Martin McNally
Osteoporosis	185	(5)
Juliet Compston
Avascular necrosis and related topics	190	(5)
D. O'Gradaigh
C. A. Speed
A. J. Crisp
Nephrology
Structure and function of the kidney	195	(7)
J. D. Williams
A. Phillips
Water and electrolyte metabolism	202	(22)
Water and sodium homeostasis and their disorders	202	(11)
Peter H. Baylis
Disorders of potassium homeostasis	213	(11)
J. Firth
Clinical presentation and investigation of renal disease	224	(24)
The clinical presentation of renal disease	224	(11)
Alex M. Davison
Clinical investigation of renal disease	235	(13)
A. Davenport
Acute renal failure	248	(15)
J. Firth
Chronic renal failure	263	(21)
Chronic renal failure	263	(15)
C. G. Winearls
Bone disease in chronic renal failure	278	(6)
Michael Schomig
Eberhard Ritz
Renal replacement therapies	284	(29)
Haemodialysis	284	(7)
Ken Farrington
Roger Greenwood
The treatment of endstage renal disease by peritoneal dialysis	291	(3)
Paul F. Williams
Renal transplantation	294	(19)
P. Sweny
Glomerular diseases	313	(38)
The glomerulus and glomerular injury	313	(4)
John Savill
IgA nephropathy and Henoch--Schonlein purpura	317	(4)
John Feehally
Thin membrane nephropathy	321	(2)
John Feehally
Minimal-change nephropathy, focal segmental glomerulosclerosis, and membranous nephropathy	323	(7)
D. Adu
Proliferative glomerulonephritis	330	(2)
Peter W. Mathiesen
Mesangiocapillary glomerulonephritis	332	(3)
Peter W. Mathiesen
Antiglomerular basement membrane disease	335	(4)
Jeremy Levy
Charles Pusey
Infection-associated nephropathies	339	(4)
A. Neil Turner
Malignancy-associated renal disease	343	(2)
A. Neil Turner
Glomerular disease in the tropics	345	(6)
Kirpal S. Chugh
Vivekanand Jha
Renal tubular disorders	351	(7)
J. Cunningham
Tubulointerstitial diseases	358	(16)
Acute interstitial nephritis	358	(3)
Dominique Droz
Dominique Chauveau
Chronic tubulointerstitial nephritis	361	(13)
Marc E. De Broe
Patrick C. D'Haese
Monique M. Elseviers
The kidney in systemic disease	374	(39)
Diabetes mellitus and the kidney	374	(6)
R. W. Bilous
Hypertension and the kidney	380	(3)
Lawrence E. Ramsay
Vasculitis and the kidney	383	(10)
A. J. Rees
The kidney in rheumatological disorders	393	(7)
D. Adu
Renal involvement in plasma cell dyscrasias, immunoglobulin-based amyloidoses, and fibrillary glomerulopathies, lymphomas, and leukaemias	400	(7)
P. Ronco
Haemolytic uraemic syndrome	407	(4)
Paul Warwicker
Timothy H. J. Goodship
Sickle-cell disease and the kidney	411	(2)
G. R. Serjeant
Renal involvement in genetic disease	413	(7)
J. P. Grunfeld
Urinary tract infection	420	(14)
C. Tomson
Urinary stones, nephrocalcinosis, and renal tubular acidosis	434	(13)
Robert J. Unwin
William G. Robertson
Giovambattista Capasso
Urinary tract obstruction	447	(15)
L. R. I. Baker
Tumours of the urinary tract	462	(6)
P. H. Smith
H. Irving
P. Harnden
Drugs and the kidney	468	(11)
D. J. S. Carmichael
Sexually-transmitted diseases and sexual health
Epidemiology	479	(5)
M. W. Adler
A. Meheus
Sexual behaviour	484	(2)
Anne M. Johnson
Vaginal discharge	486	(3)
J. Schwebke
S. L. Hillier
Pelvic inflammatory disease	489	(2)
David Eschenbach
Infections and other medical problems in homosexual men	491	(5)
A. McMillan
Cervical cancer and other cancers caused by sexually tramsmitted infections	496	(5)
V. Beral
Disorders of the blood
Introduction	501	(7)
D. J. Weatherall
Haematopoietic stem cells	508	(12)
Stem cells and haemopoiesis	508	(7)
C. A. Sieff
D. G. Nathan
Stem-cell disorders	515	(5)
D. C. Linch
The leukaemias and other disorders of haematopoietic stem cells	520	(65)
Cell and molecular biology of human leukaemias	520	(5)
Thomas Look
The classification of leukaemia	525	(4)
D. Catovsky
Acute lymphoblastic leukaemia	529	(4)
Philip J. Burke
Acute myeloblastic leukaemia	533	(6)
Philip J. Burke
Chronic lymphocytic leukaemia and other leukaemias of mature B and T cells	539	(7)
D. Catovsky
Chronic myeloid leukaemia	546	(6)
Tariq I. Mughal
John M. Goldman
Myelodysplasia	552	(5)
Lawrence B. Gardner
Chi V. Dang
The polycythaemias	557	(7)
David M. Gustin
Ronald Hoffman
Idiopathic myelofibrosis	564	(4)
Jerry L. Spivak
Thrombocytosis	568	(5)
David M. Gustin
Ronald Hoffman
Aplastic anaemia and other causes of bone marrow failure	573	(8)
E. C. Gordon-Smith
Paroxysmal nocturnal haemoglobinuria	581	(4)
Lucio Luzzatto
The white cells and lymphoproliferative disorders	585	(49)
Leucocytes in health and disease	585	(6)
Joseph Sinning
Nancy Berliner
Introduction to the lymphoproliferative disorders	591	(4)
Barbara A. Degar
Nancy Berliner
Lymphoma	595	(14)
James O. Armitage
The spleen and its disorders	609	(7)
D. Swirsky
Myeloma and paraproteinaemias	616	(8)
Robert A. Kyle
Eosinophilia	624	(5)
Peter F. Weller
Histiocytoses	629	(5)
D. K. H. Webb
The red cell	634	(92)
Erythropoiesis and the normal red cell	634	(5)
Anna Rita Migliaccio
Thalia Papayannopoulou
Anaemia: pathophysiology, classification, and clinical features	639	(5)
D. J. Weatherall
Anaemia as a world health problem	644	(4)
D. J. Weatherall
Iron metabolism and its disorders	648	(9)
T. M. Cox
Normochromic, normocytic anaemia	657	(2)
D. J. Weatherall
Megaloblastic anaemia and miscellaneous deficiency anaemias	659	(17)
A. V. Hoffbrand
Disorders of the synthesis or function of haemoglobin	676	(20)
D. J. Weatherall
Anaemias resulting from defective red cell maturation	696	(4)
James S. Wiley
Haemolytic anaemia---congenital and acquired	700	(10)
Frank J. Strobl
Leslie Silberstein
Disorders of the red cell membrane	710	(6)
Patrick G. Gallagher
Sara S. T. O. Saad
Fernando F. Costa
Erythrocyte enzymopathies	716	(4)
Ernest Beutler
Glucose-6-phosphate dehydrogenase (G6PD) deficiency	720	(6)
Lucio Luzzatto
Haemostasis and thrombosis	726	(54)
The biology of haemostasis and thrombosis	726	(15)
Harold R. Roberts
Gilbert C. White, II
Evaluation of the patient with a bleeding diathesis	741	(7)
Gilbert C. White, II
Harold R. Roberts
Victor J. Marder
Disorders of platelet number and function	748	(9)
Kathryn E. Webert
John G. Kelton
Genetic disorders of coagulation	757	(10)
Eleanor S. Pollak
Katherine A. High
Acquired coagulation disorders	767	(13)
T. E. Warkentin
The blood in systemic disease	780	(11)
D. J. Weatherall
Blood replacement	791	(18)
Blood transfusion	791	(9)
P. L. Perrotta
E. L. Snyder
Haemopoietic stem cell transplantation	800	(9)
E. C. Gordon-Smith
Diseases of the skin
Diseases of the skin	809	(86)
T. J. Ryan
R. Sinclair
Molecular basis of inherited skin disease	895	(12)
Irene M. Leigh
David P. Kelsell
Neurology
Introduction and approach to the patient with neurological disease	907	(3)
Alastair Compston
Electrophysiology of the central and peripheral nervous systems	910	(15)
Christian Krarup
Brain and mind: functional neuroimaging	925	(3)
Richard Frackowiak
Investigation of central motor pathways: magnetic brain stimulation	928	(3)
K. R. Mills
Imaging in neurological diseases	931	(9)
Andrew J. Molyneux
Philip Anslow
Inherited disorders	940	(13)
Inherited disorders	940	(5)
P. K. Thomas
Neurogenetics	945	(8)
Nicholas Wood
Lumbar puncture	953	(3)
Robert A. Fishman
Disturbances of higher cerebral function	956	(7)
Peter Nestor
John R. Hodges
Brainstem syndromes	963	(4)
David Bates
Subcortical structures---the cerebellum, thalamus, and basal ganglia	967	(5)
N. P. Quinn
Visual pathways	972	(6)
Christopher Kennard
Disorders of eye and ear	978	(10)
Eye movements and balance	978	(6)
Thomas Brandt
Michael Strupp
Disorders of hearing	984	(4)
Linda M. Luxon
Diseases of the nervous system	988	(127)
The unconscious patient	988	(5)
David Bates
Headache	993	(8)
Peter J. Goadsby
Epilepsy in later childhood and adults	1001	(13)
G. D. Perkin
Narcolepsy	1014	(2)
David Parkes
Syncope	1016	(3)
L. D. Blumhardt
Head-up tilt-table testing in the diagnosis of vasovagal syncope and related disorders	1019	(1)
Steve W. Parry
Rose Anne Kenny
Brain death and the vegetative state	1020	(2)
B. Jennett
Stroke: cerebrovascular disease	1022	(12)
J. van Gijn
Alzheimer's disease and other dementias	1034	(12)
Clare J. Galton
John R. Hodges
Human prion disease	1046	(7)
R. G. Will
Parkinsonism and other extrapyramidal diseases	1053	(5)
Donald B. Calne
Disorders of movement (excluding Parkinson's disease)	1058	(10)
Roger Barker
Ataxic disorders	1068	(7)
Nicholas Wood
The motor neurone diseases	1075	(4)
Michael Donaghy
Diseases of the autonomic nervous system	1079	(10)
Christopher J. Mathias
Disorders of cranial nerves	1089	(4)
P. K. Thomas
Diseases of the spinal cord	1093	(5)
L. D. Blumhardt
Spinal cord injury and its management	1098	(7)
M. P. Barnes
Traumatic injuries of the head	1105	(1)
Intracranial tumours	1105	(3)
Jeremy Rees
Traumatic injuries of the head	1108	(4)
Lawrence Watkins
David G. T. Thomas
Benign intracranial hypertension	1112	(3)
N. F. Lawton
Infections of the nervous system	1115	(34)
Bacterial meningitis	1115	(14)
D. A. Warrell
J. J. Farrar
D. W. M. Crook
Viral infections of the central nervous system	1129	(11)
D. A. Warrell
J. J. Farrar
Intracranial abscess	1140	(2)
P. J. Teddy
Neurosyphilis and neuroAIDS	1142	(7)
Hadi Manji
Metabolic disorders and the nervous system	1149	(7)
Neil Scolding
C. D. Marsden
Demyelinating disorders of the central nervous system	1156	(11)
Alastair Compston
Disorders of the neuromuscular junction	1167	(6)
David Hilton-Jones
Jackie Palace
Paraneoplastic syndromes	1173	(7)
Jerome B. Posner
Diseases of the peripheral nerves	1180	(14)
P. K. Thomas
Neurological complications of systemic autoimmune and inflammatory diseases	1194	(7)
Neil Scolding
Developmental abnormalities of the central nervous system	1201	(15)
C. M. Verity
H. Firth
C. ffrench-Constant
Disorders of muscle	1216	(39)
Introduction: structure and function	1216	(4)
M. Hanna
Muscular dystrophy	1220	(15)
K. Bushby
Myotonia	1235	(5)
David Hilton-Jones
Metabolic and endocrine disorders	1240	(7)
David Hilton-Jones
Richard Edwards
Mitochondrial encephalomyopathies	1247	(4)
P. F. Chinnery
D. M. Turnbull
Tropical pyomyositis (tropical myositis)	1251	(4)
D. A. Warrell
The eye
The eye in general medicine	1255	(14)
Peggy Frith
Psychiatry and drug related problems
General introduction	1269	(1)
Michael Sharpe
Taking a psychiatric history from a medical patient	1270	(3)
Eleanor Feldman
Neuropsychiatric disorders	1273	(10)
Laurence John Reed
Tom Stevens
Michael D. Kopelman
Acute behavioural emergencies	1283	(4)
Eleanor Feldman
Psychiatric disorders as they concern the physician	1287	(31)
Grief, stress, and post-traumatic stress disorder	1287	(6)
Jenny Yiend
Tim Dalgleish
The patient who has attempted suicide	1293	(3)
Keith Hawton
Medically unexplained symptoms in patients attending medical clinics	1296	(7)
Christopher Bass
Michael Sharpe
Anxiety and depression	1303	(7)
L. Chwastiak
W. Katon
Eating disorders	1310	(4)
Christopher G. Fairburn
Schizophrenia, bipolar disorder, obsessive--compulsive disorder, and personality disorder	1314	(4)
S. Lawrie
Psychiatric treatments	1318	(10)
Psychopharmacology in medical practice	1318	(7)
P. J. Cowen
Psychological treatment in medical practice	1325	(3)
Michael Sharpe
Simon Wessely
Alcohol and drug related problems	1328	(17)
Alcohol and drug dependence	1328	(6)
Mary E. McCaul
Gary S. Wand
Brief interventions against excessive alcohol consumption	1334	(3)
Nick Heather
Eileen Kaner
Problems of alcohol and drug users in the hospital	1337	(8)
Carol Ann Huff
Forensic medicine and the practising doctor
Forensic medicine and the practising doctor	1345	(12)
Anthony Busuttil
Sports and exercise medicine
Sports and exercise medicine	1357	(12)
R. Wolman
Adolescent medicine
Adolescent medicine	1369	(6)
R. Viner
Geratology
Medicine in old age	1375	(17)
John Grimley Evans
Mental disorders of old age	1392	(5)
Robin Jacoby
Palliative care
Palliative care	1397	(14)
Robert Twycross
Mary Miller
Reference intervals for biochemical data
Reference intervals for biochemical data	1411	(18)
P. A. H. Holloway
A. M. Giles
Emergency medicine
Emergency medicine	1429
J. Firth
C. A. Eynon
D. A. Warrell
T. M. Cox
Index