9783805572361

Oxidative Stress in Mitochondria Disorders of Aging : Mitochondria in Disease States

by
  • ISBN13:

    9783805572361

  • ISBN10:

    3805572360

  • Format: Paperback
  • Copyright: 2001-05-01
  • Publisher: S Karger Pub
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Summary

Neurons are particularly vulnerable to age-associated decline in mitochondrial function due to their high energy demand. Thus, several models are proposed implicating mtDNA damage and mutation, and subsequent mitochondrial dysfunction, as an underlying factor in a substantial number of human pathologies including aging, neurodegenerative and neuromuscular diseases, and ischemia-reperfusion injury. Furthermore, the results of clinical, biochemical and molecular biology studies suggest that defective mitochondria contribute to neurodegenerative diseases in humans. For example, Friedreich s ataxia exhibits mitochondrial iron overload, Huntington s disease is characterized by defects in mitochondrial oxidative phosphorylation and aconitase deficiency, Parkinson s disease is associated with a deficiency in mitochondrial complex I activity, and Alzheimer s disease exhibits cytochrome oxidase deficiency. Neurologists, psychiatrists and biochemists will profit most from this special issue.

Table of Contents

Mitochondria and Apoptosis
147(15)
Gottlieb, R.A.
The Mitochondrial Theory of Aging
162(14)
Kowald, A.
Mitochondrial Membrane Potential in Aging Cells
176(13)
Sugrue, M.M.
Tatton, W.G.
Mitochondrial Catalase and Oxidative Injury
189(11)
Bai, J.
Cederbaum, A.I.
Mitochondrial Ca2+Signaling and Cardiac Apoptosis
200(24)
Pacher, P.
Csordas, G.
Hajnoczky, G.
Ubiquinone (Coenzyme Q10) and Mitochondria in Oxidative Stress of Parkinson's Disease
224(30)
Ebadi, M.
Govitrapong, P.
Sharma, S.
Muralikrishnan, D.
Shavali, S.
Pellett, L.
Schafer, R.
Albano, C.
Eken, J.
Mitochondrial Function and Alzheimer's Disease
254(9)
Ojaimi, J.
Byrne, E.
Mitochondrial Dysfunction in Friedreich's Ataxia
263(8)
Lodi, R.
Taylor, D.J.
Schapira, A.H.V.
Ethanol Consumption and Liver Mitochondria Function
271(12)
Cunningham, C.C.
Bailey, S.M.
Author Index 283(1)
Subject Index 284

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