Oxidative Stress in Mitochondria Disorders of Aging : Mitochondria in Disease States

  • ISBN13:


  • ISBN10:


  • Format: Paperback
  • Copyright: 2001-05-01
  • Publisher: S Karger Pub
  • Purchase Benefits
  • Free Shipping On Orders Over $35!
    Your order must be $35 or more to qualify for free economy shipping. Bulk sales, PO's, Marketplace items, eBooks and apparel do not qualify for this offer.
  • Get Rewarded for Ordering Your Textbooks! Enroll Now
List Price: $39.25
We're Sorry.
No Options Available at This Time.


Neurons are particularly vulnerable to age-associated decline in mitochondrial function due to their high energy demand. Thus, several models are proposed implicating mtDNA damage and mutation, and subsequent mitochondrial dysfunction, as an underlying factor in a substantial number of human pathologies including aging, neurodegenerative and neuromuscular diseases, and ischemia-reperfusion injury. Furthermore, the results of clinical, biochemical and molecular biology studies suggest that defective mitochondria contribute to neurodegenerative diseases in humans. For example, Friedreich s ataxia exhibits mitochondrial iron overload, Huntington s disease is characterized by defects in mitochondrial oxidative phosphorylation and aconitase deficiency, Parkinson s disease is associated with a deficiency in mitochondrial complex I activity, and Alzheimer s disease exhibits cytochrome oxidase deficiency. Neurologists, psychiatrists and biochemists will profit most from this special issue.

Table of Contents

Mitochondria and Apoptosis
Gottlieb, R.A.
The Mitochondrial Theory of Aging
Kowald, A.
Mitochondrial Membrane Potential in Aging Cells
Sugrue, M.M.
Tatton, W.G.
Mitochondrial Catalase and Oxidative Injury
Bai, J.
Cederbaum, A.I.
Mitochondrial Ca2+Signaling and Cardiac Apoptosis
Pacher, P.
Csordas, G.
Hajnoczky, G.
Ubiquinone (Coenzyme Q10) and Mitochondria in Oxidative Stress of Parkinson's Disease
Ebadi, M.
Govitrapong, P.
Sharma, S.
Muralikrishnan, D.
Shavali, S.
Pellett, L.
Schafer, R.
Albano, C.
Eken, J.
Mitochondrial Function and Alzheimer's Disease
Ojaimi, J.
Byrne, E.
Mitochondrial Dysfunction in Friedreich's Ataxia
Lodi, R.
Taylor, D.J.
Schapira, A.H.V.
Ethanol Consumption and Liver Mitochondria Function
Cunningham, C.C.
Bailey, S.M.
Author Index 283(1)
Subject Index 284

Rewards Program

Write a Review