The p53 Protein: From Cell Regulation to Cancer

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2016-03-31
  • Publisher: Cold Spring Harbor Laboratory Press

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Supplemental Materials

What is included with this book?


Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations.

Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.

Table of Contents



p53 Isoforms: Key Regulators of the Cell Fate Decision
S.M. Joriuz and Jean-Christophe Bourdon

The Transactivation Domains of the p53 Protein
Nitin Raj and Laura D. Attardi

Tumor Suppressor Functions of the TP53 Pathway
Brandon J. Aubrey, Andreas Strasser, and Gemma L. Kelly

p53 in the DNA Damage Repair Process
Ashley B. Williams and Björn Schumacher

Genome Stability Requires p53
Christine M. Eischen

The Cell Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Jiandong Chen

Autophagy and p53
Eileen White

The Evolution of the Ribosomal Protein-MDM2-p53 Pathway
Chad Deisenroth, Derek A. Franklin, and Yangping Zhang

Regulation of Cellular Metabolism and Hypoxia by p53
Timothy J. Humpton and Karen H. Vousden

The Role of the p53 Protein in Stem Cell Biology and Epigenetic Regulation
Arnold J. Levine, Anna M. Puzio-Kuter, Chang S. Chan, and Pierre Hainaut

p53 and the Carcinogenicity of Chronic Inflammation
Andrei V. Gudkov and Elena A. Komarova

Somatic TP53 Mutations in the Era of Genome Sequencing
Pierre Hainault and Gerd Pfeifer

The Inherited p53 Mutation in the Brazilian Population
Maria Isabel Achatz and Gerard P. Zambetti

Oncogenic Mutant p53 Gain-of-Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem Cells Formation
Yoav Shetzer, Alina Molchadsky, and Varda Rotter

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End
Amanda R. Wasylishen and Guillermina Lozano

The Role of MDM2 Amplification and Overexpression in Turmorigenesis
Jonathan D. Oliner, Anne Y. Saliki, and Sean Caenepeel

MDMX (MDM4), A Promising Target for p53 Reactivation Therapy and Beyond
Jean-Christophe Marine and Aart G. Jochemsen

P53 as an Effector or Inhibitor of Therapy Response
Julien Ablain, Brigitte Poirot, Cécile Esnault, Jacqueline Lehmann-Che, and
Hugues de Thé

p53 and Medulloblastoma
Vijay Ramaswamy, Carolina Nor, and Michael D. Taylor

Clinical Outcomes of TP53 Mutations in Cancers
Ana I. Robles, Jin Jen, and Curtis C. Harris

Genetic Modifiers of the p53 Pathway
Subhasree Basu and Maureen E. Murphy

The Paradox of p53: What, How, and Why?
Yael Aylon and Moshe Oren


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