Perspectives on Genetics: Anecdotal, Historical, and Critical Commentaries, 1987-1998

by Crow, James F.; Dove, William F.

• ISBN13: 9780299166045
• ISBN10: 029916604X
• Edition: Reprint
• Format: Paperback
• Copyright: 2000-06-01
• Publisher: Univ of Wisconsin Pr

Summary

For more than ten years, the distinguished geneticists James F. Crow and William F. Dove have edited the popular "Perspectives" column in Genetics, the journal of the Genetics Society of America. This book, Perspectives on Genetics, collects more than 100 of these essays, which cumulatively are a history of modern genetics research and its continuing evolution.

Author Biography

James F. Crow is professor emeritus of genetics and zoology and William F. Dove is professor of oncology and medical genetics, both at the University of Wisconsin-Madison

Table of Contents

Introduction	xiii
James F. Crow
William F. Dove
Sewall Wright and Physiological Genetics	3	(2)
James F. Crow
Paradox Found	5	(2)
William F. Dove
Seventy Years Ago in Genetics: H. S. Jennings and Inbreeding Theory	7	(3)
James F. Crow
Twenty Years of Illegitimate Recombination	10	(3)
Philip Anderson
Molecular Genetics of Mus musculus: Point Mutagenesis and Millimorgans	13	(4)
William F. Dove
Twenty-five Years Ago in Genetics: Motoo Kimura and Molecular Evolution	17	(2)
James F. Crow
The waxy Locus in Maize Twenty-five Years Later	19	(4)
Oliver E. Nelson
Doing Behavioral Genetics with Bacteria	23	(2)
John S. Parkinson
Gene Recombination and Linked Segregations in Escherichia coli	25	(4)
Joshua Lederberg
A Mouse Phoenix Rose from the Ashes	29	(2)
Elizabeth S. Russell
``In the Air'' -- Theodosius Dobzhansky's Genetics and the Origin of Species	31	(4)
Jeffrey R. Powell
Quantitative Genetics in 1987	35	(2)
B. S. Weir
A Diamond Anniversary: The First Chromosome Map	37	(3)
James F. Crow
The Year of the Fly	40	(3)
William F. Dove
The Ultraselfish Gene	43	(3)
James F. Crow
Notes of a Bigamous Biologist	46	(2)
Gerald R. Fink
Cytogenetics and Karl Sax	48	(3)
Carl P. Swanson
H. J. Muller, Communism, and the Cold War	51	(3)
Diane Paul
Eighty Years Ago: The Beginnings of Population Genetics	54	(4)
James F. Crow
A Diamond in a Desert	58	(3)
Herschel Roman
Unequal Crossing Over Then and Now	61	(6)
Kenneth D. Tartof
The Genesis of Dysgenesis	67	(4)
James F. Crow
Between Novembers: Demerec, Cold Spring Harbor, and the Gene	71	(5)
Philip E. Hartman
The Hawthorne Deletion Twenty-five Years Later	76	(5)
Ira Herskowitz
Early Worms	81	(3)
Jonathan Hodgkin
There's a Whole Lot of Shaking Going On	84	(4)
Barry Ganetzky
Replica Plating and Indirect Selection of Bacterial Mutants: Isolation of Preadaptive Mutants in Bacteria by Sib Selection	88	(5)
Joshua Lederberg
Twenty-five Years Ago in Genetics: The Infinite Allele Model	93	(4)
James F. Crow
Evolving Theories of Enzyme Evolution	97	(6)
Daniel L. Hartl
Gustave Malecot and the Transition from Classical to Modern Population Genetics	103	(16)
Thomas Nagylaki
Fortunes of War	119	(3)
James F. Crow
In Praise of Complexity	122	(5)
Salome Gluecksohn Waelsch
M. R. Irwin and the Beginnings of Immunogenetics	127	(4)
Ray Owen
The Linkage Map of Phage T4	131	(4)
Franklin W. Stahl
The Molecular Genetics of Differentiation	135	(3)
Bert Ely
Lucy Shapiro
Intragenic Recombination in Drosophila: The rosy Locus	138	(4)
Arthur Chovnick
R. A. Fisher, A Centennial View	142	(5)
James F. Crow
Regulating Tn10 and IS10 Transposition	147	(6)
Nancy Kleckner
The Foundations of Genetic Fine Structure: A Retrospective from Memory	153	(4)
M. M. Green
Studies of Yeast Cytochrome c: How and Why They Started and Why They Continued	157	(4)
Fred Sherman
L. C. Dunn and Mouse Genetic Mapping	161	(6)
Mary F. Lyon
The Role of Similarity and Difference in Fungal Mating	167	(6)
Robert L. Metzenberg
Mapping Functions	173	(3)
James F. Crow
``Joy of the Worm''	176	(6)
H. Robert Horvitz
John E. Sulston
Genes and Development: Molecular and Logical Themes	182	(8)
Sydney Brenner
William F. Dove
Ira Herskowitz
Rene Thomas
Sixty Years of Mystery	190	(6)
Allan C. Spradling
Gary H. Karpen
Our Diamond Birthday Anniversary	196	(3)
James F. Crow
Haldane's Solution of the Luria-Delbruck Distribution	199	(5)
Sahotra Sarkar
Fifty Years Ago: The Neurospora Revolution	204	(5)
Norman H. Horowitz
Tomato Paste: A Concentrated Review of Genetic Highlights from the Beginnings to the Advent of Molecular Genetics	209	(5)
Charles M. Rick
Impact of the Douglas-Hawthorne Model as a Paradigm for Elucidating Cellular Regulatory Mechanisms in Fungi	214	(7)
Yasuji Oshima
The Regulation of Arginine Biosynthesis: Its Contribution to Understanding the Control of Gene Expression	221	(6)
Werner K. Maas
Twenty-five Years Ago in Genetics: Electrophoresis in the Development of Evolutionary Genetics-Milestone or Millstone?	227	(6)
R. C. Lewontin
Alfred Henry Sturtevant and Crosses between Drosophila melanogaster and Drosophila simulans	233	(5)
William B. Provine
The Gene (H. J. Muller 1947)	238	(4)
Joshua Lederberg
Qualitative and Quantitative Genetic Studies of Arabidopsis thaliana	242	(5)
Bruce Griffing
Randall L. Scholl
Twenty-five Years of Cell Cycle Genetics	247	(6)
Leland H. Hartwell
Centennial: J. B. S. Haldane, 1892--1964	253	(6)
James F. Crow
Erwin Schrodinger and the Hornless Cattle Problem	259	(3)
James F. Crow
Twenty-five Years Ago in Genetics: Identical Triplets	262	(4)
James F. Crow
Neurospora: The Organism behind the Molecular Revolution	266	(15)
David D. Perkins
Looking for the Homunculus in Drosophila	281	(3)
Alan Garen
What Did Gregor Mendel Think He Discovered?	284	(9)
Daniel L. Hartl
Vitezslav Orel
Molecular Genetics under an Embryologist's Microscope: Jean Brachet, 1909-1988	293	(4)
Rene Thomas
Sixty Years Ago: The 1932 International Congress of Genetics	297	(5)
James F. Crow
On the Beginnings of Somatic Cell Hybridization: Boris Ephrussi and Chromosome Transplantation	302	(8)
Doris T. Zallen
Richard M. Burian
Forty Years Ago: The Discovery of Bacterial Transduction	310	(4)
Norton D. Zinder
Forty Years Ago in Genetics: The Unorthodox Mating Behavior of Bacteria	314	(3)
L. Luca Cavalli-Sforza
Unicorns Revisited	317	(3)
Franklin W. Stahl
Felix Bernstein and the First Human Marker Locus	320	(4)
James F. Crow
Quantitative Genetics in Edinburgh: 1947--1980	324	(6)
Douglas Falconer
Thirty Years Ago in Genetics: Prophage Insertion into Bacterial Chromosomes	330	(5)
Allan M. Campbell
William Ernest Castle: Pioneer Mammalian Geneticist	335	(3)
George D. Snell
Sheldon Reed
N. I. Vavilov, Martyr to Genetic Truth	338	(4)
James F. Crow
The Discovery of Mustard Gas Mutagenesis by Auerbach and Robson in 1941	342	(7)
Geoffrey Beale
Morgan's Hypothesis of the Genetic Control of Development	349	(4)
Raphael Falk
Sara Schwartz
The Gene, the Polygene, and the Genome	353	(4)
William F. Dove
Francis Galton: Count and Measure, Measure and Count	357	(4)
James F. Crow
Roland Thaxter's Legacy and the Origins of Multicellular Development	361	(6)
Dale Kaiser
Meiosis as an ``M'' Thing: Twenty-five Years of Meiotic Mutants in Drosophila	367	(6)
R. Scott Hawley
A Notable Triumvirate of Maize Geneticists	373	(5)
Oliver E. Nelson
Allozymes in Evolutionary Genetics: Self-Imposed Burden or Extraordinary Tool?	378	(6)
Ward B. Watt
The Transformation of Genetics by DNA: An Anniversary Celebration of Avery, MacLeod, and McCarty (1944)	384	(4)
Joshua Lederberg
Sturtevant's Mantle and the (Lost?) Art of Chromosome Mechanics	388	(2)
John C. Lucchesi
Harvard, Agriculture, and the Bussey Institution	390	(5)
J. A. Weir
Archibald Edward Garrod: The Reluctant Geneticist	395	(4)
Alexander G. Bearn
Transparent Vertebrates and Their Genetic Images	399	(3)
William F. Dove
A Century of Homeosis, A Decade of Homeoboxes	402	(5)
William McGinnis
Hitoshi Kihara, Japan's Pioneer Geneticist	407	(4)
James F. Crow
A Reconsideration of the Mechanism of Position Effect	411	(5)
Steven Henikoff
The Holliday Junction on Its Thirtieth Anniversary	416	(6)
Franklin W. Stahl
Discovery and Genetic Definition of the Drosophila Antennapedia Complex	422	(4)
Rob Denell
The Evolution of Somatic Selection: The Antibody Tale	426	(7)
Gerald M. Edelman
Early Days of Gel Electrophoresis	433	(4)
O. Smithies
The Fifties and the Renaissance in Human and Mammalian Cytogenetics	437	(6)
Orlando J. Miller
The Cold Spring Harbor Phage Course (1945--1970): A Fiftieth Anniversary Remembrance	443	(6)
Millard Susman
Vicious Circles: Looking Back on Resistance Plasmids	449	(4)
Julian Davies
LODs Past and Present	453	(6)
Newton E. Morton
Quarreling Geneticists and a Diplomat	459	(6)
James F. Crow
Galton and Identification by Fingerprints	465	(4)
Stephen M. Stigler
Two Genes, No Enzyme: A Second Look at Barbara McClintock and the 1951 Cold Spring Harbor Symposium	469	(6)
Nathaniel C. Comfort
Emil Heitz (1892--1965): Chloroplasts, Heterochromatin, and Polytene Chromosomes	475	(8)
Helmut Zacharias
The Amber Mutants of Phage T4	483	(4)
Franklin W. Stahl
Chromosome Behavior in Cell Differentiation: A Field Ripe for Exploration?	487	(6)
Eeva Therman
Remembering Sturtevant	493	(4)
E. B. Lewis
Embryonic Transcription and the Control of Developmental Pathways	497	(6)
Eric Wieschaus
The ``Genesis of the White-Eyed Mutant'' in Drosophila melanogaster: A Reappraisal	503	(3)
M. M. Green
Lancelot Hogben, 1895--1975	506	(6)
Sahotra Sarkar
Worm Spadework	512	(4)
Robert K. Herman
The Sixtieth Anniversary of Biochemical Genetics	516	(4)
N. H. Horowitz
A Metabolic Basis for Dominance and Recessivity	520	(5)
Peter D. Keightley
Alexander Hollaender: Myth and Mensch	525	(6)
R. C. von Borstel
Charles M. Steinberg
Sewall Wright's ``Systems of Mating''	531	(8)
William G. Hill
Recollections of Howard Temin (1934--1994)	539	(6)
John W. Drake
James F. Crow
Genetic Recombination in Escherichia coli: Disputation at Cold Spring Harbor, 1946--1996	545	(5)
Joshua Lederberg
A Golden Anniversary: Cattle Twins and Immune Tolerance	550	(5)
James F. Crow
Dobzhansky, Bateson, and the Genetics of Speciation	555	(5)
H. Allen Orr
Invasions of P Elements	560	(5)
William R. Engels
Whatever Happened to Paramecium Genetics?	565	(9)
John R. Preer, Jr.
Reassessing Forty Years of Genetic Doctrine: Retrotransfer and Conjugation	574	(7)
Robert G. Ankenbauer
Ultraviolet-Induced Mutation and the Chemical Nature of the Gene	581	(3)
David Stadler
Chromosome Changes in Cell Differentiation	584	(8)
Orlando J. Miller
mutS, Proofreading, and Cancer	592	(4)
Edward C. Cox
Recombination and Population Structure in Escherichia coli	596	(6)
Roger Milkman
The Value of Basic Research: Discovery of Thermus aquaticus and Other Extreme Thermophiles	602	(4)
Thomas D. Brock
Birth Defects, Jimson Weeds, and Bell Curves	606	(6)
James F. Crow
Dobzhansky's Genetics and the Origin of Species: Is It Still Relevant?	612	(5)
Richard C. Lewontin
The Weaker Sex Is Heterogametic: Seventy-five Years of Haldane's Rule	617	(15)
Cathy C. Laurie
Seventy Years Ago: Mutation Becomes Experimental	632	(6)
James F. Crow
Seymour Abrahamson
An Oak Ridge Legacy: The Specific Locus Test and Its Role in Mouse Mutagenesis	638	(6)
Allan Peter Davis
Monica J. Justice
The Engrailed Story	644	(6)
Antonio Garcia-Bellido
Ninety Years Ago: The Beginning of Hybrid Maize	650	(6)
James F. Crow
Hershey	656	(6)
Franklin W. Stahl
Anatomy of a Revolution	662	(5)
Gerald R. Fink
The Language of Gene Interaction	667	(5)
Patrick C. Phillips
T. H. Morgan at Caltech: A Reminiscence	672	(4)
Norman H. Horowitz
Genes and Chromomeres: A Puzzle in Three Dimensions	676	(9)
Burke H. Judd
An Extract from ``Memoirs for Family and Friends''	685	(3)
John Tyler Bonner
Marcus Rhoades and Transposition	688	(5)
Nina Fedoroff
Lionel Sharples Penrose, 1898--1972: A Personal Memoir in Celebration of the Centenary of His Birth	693	(10)
Renata Laxova
Addenda et Corrigenda	703	(4)
Author Index	707	(2)
Subject Index	709