Pharmacogenomics of Human Drug Transporters : Clinical Impacts

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2013-04-15
  • Publisher: Wiley

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Emphasizing pharmacogenomics and its influence on drug therapy, this book offers a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the individual patients body. It covers new and emerging aspects of drug transporter pharmacogenomics, from the basic science, to transporter function, factors that influence transporters, impact on bioavailability and disposition, metabolism-transport interplay, pharmaceutical applications, and regulatory matters. The book has sufficient detail for non-specialists while also providing a practical, hands-on resource for researchers in the pharmaceutical industry, academic research, and government agencies.

Author Biography

TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC).

RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation.

JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.

Table of Contents



Chapter 1: Introduction to pharmacogenomics of drug transporters
Marianne K DeGorter and Richard B Kim

Chapter 2: ADME Pharmacogenomics in Drug Development
Liangfu Chen and Joseph W. Polli

Chapter 3: Regulatory Perspective on Pharmacogenomics of Drug Metabolizing Enzymes and Transporters
Lei Zhang, Gilbert J. Burckart, Shiew-Mei Huang and Lawrence J. Lesko

Chapter 4: The Pharmacogenomics of Membrane Transporters Project
Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini

Chapter 5: Emerging new technology of SNP typing
Toshihisa Ishikawa and Yoshihide Hayashizaki

Chapters 6: OATP1A2, OAT1 and OAT3
Rommel G. Tirona

Chapter 7: OATP1B1, OATB1B3 and OATP2B1
Jörg König and Martin Fromm

Chapter 8: OCT (SLC22A) and OCTN Families
Sophie L. Stocker, Kathleen M. Giacomini, Arian Emami-Riedmaier and A. Matthias Schwab

Chapter 9: MATE (SLC47) Family

Atsushi Yonezawa andKen-ichi Inui

Chapter 10: PEPT (SLC15A) Family
Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato

Chapter 11: Nucleoside Transporters (SLC28 and SLC29) Family
Míriam Molina-Arcas and Marçal Pastor-Anglada

Chapter 12: P-Glycoprotein (MDR1/ABCB1)
Ingolf Cascorbi

Chapter 13: Bile Salt Export Pump BSEP (ABCB11): Role in Liver Physiology and Liver Disease
Gerd Ullak-Kublick and Bruno Stieger

Chapter 14: BCRP (ABCG2)
Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom

Chapter 15: MRP2 (ABCC2) and MRP3 (ABCC3)
Anne T. Nies

Chapter 16: MRP4 (ABCC4)
Satish B.Cheepala, Mugdha Sukthankar and John D. Schuetz

Chapter 17: MRP8 (ABCC11)
Yu Toyoda and Toshihisa Ishikawa

Chapter 18: Future Perspectives
Toshihisa Ishikawa and Joseph Ware


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