A Practical Guide to Human Cancer Genetics

by Shirley V. Hodgson , Eamonn R. Maher , With contributions by Julia Newton-Bishop

• ISBN13: 9780521649612
• ISBN10: 0521649617
• Edition: 2nd
• Format: Paperback
• Copyright: 1999-08-13
• Publisher: Cambridge University Press

Summary

This extensively up-dated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics - an area that has made significant advances since publication of the first edition. The opening section presents the the principles of cancer genetics and introduces the basic concepts and mechanisms of tumourigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section then deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. Up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers are also provided. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.

Table of Contents

Foreword

Preface

Part I. General Principles of Cancer Genetics: Chromosomes and cancer

Molecular genetics of cancer

Genetic predisposition to cancer

Ethical issues in human cancer genetics

Part II. Genetics of Human Cancer by Site of Origin: Central nervous system

Eye

Cardiorespiratory system and thorax

endocrine system

Gastro-intestinal system

Reproductive system

Urinary system

Haematological and lymphoid neoplasia

Musculoskeletal system

Skin tumours and inherited disorders predisposing to skin tumours

Inherited conditions predisposing to dermatological malignancy

Part III. Inherited Cancer-Predisposing Syndromes: Appendix

Index.