Principles of Medical Biology Vol. 9A & B : Microbiology

by Bittar, E. Edward; Bittar, Neville

• ISBN13: 9781559388146
• ISBN10: 1559388145
• Format: Hardcover
• Copyright: 1998-07-01
• Publisher: Elsevier Science Serials

Summary

There is a need in small group teaching for a readable module that provides a balanced treatment of the four main areas of medical microbiology-bacteriology, mycology, virology and parasistology. It need not be encyclopedic in scope nor didactic, but it should emphasise principles and concepts. Any existing gaps in this type of presentation are, of course, left for the student to fill. Some subject material has been excluded. An example is a chapter on laboratory procedures including PCR for rapid bacterial and viral diagnosis. The discussion of bacterial sexually transmitted diseases does not cover goncoccal infections. This is not a serious matter because the tutor can assign the topic to the students. Moreover, we have reluctantly omitted a separate chapter on anaerobic bacteria. The subject of nosocomial pathogens is touched upon but not in sufficient detail (e.g., control). These bacteria (e.g., S. aureus, E. coli and pseudomonas) are found in hospitals and are resistant to disinfectants and antibiotics. A new but serious problem is the emergence of resistance to antiviral agents. Without question, molecular biology owes more to the study of viruses than bacteria. The fact remains, however, that effective therapy against most viral diseases is not yet available. Perhaps one of the most dramatic examples of this situation is the fight against the AIDS virus and the search for a vaccine. The public health challenge of AIDS remains formidable in spite of the recent encouraging results obtained with protease inhibitor therapy. At the moment at least six receptors for HIV are known to be present in human cells. One of them is the CCR5 receptor in the absence of which cells fail to get infected with the virus. Drugs that can interrupt CCR5 binding sites on the virus envelope are being vigorously sought. Thus, Volume 9B gives a large place to HIV disease. The last group of chapters highlight several features of microbiology which are also of clinical importance and heuristic value. The chapter on fever of unknown origin provides fertile soil for problem based learning.

Table of Contents

Volume 9A
List of Contributors	xi	(8)
Preface	xix
E. Edward Bittar
Neville Bittar
Chapter 1 Ultrastructure of Bacteria	1	(14)
Spencer A. Benson
Chapter 2 The Bacterial Outer Membrane and Surface Permeability	15	(8)
Spencer A. Benson
Chapter 3 Bacterial Metabolism	23	(18)
Harris Bernstein
Carol Bernstein
Chapter 4 Bacterial Genetics	41	(24)
Stanley R. Maloy
Chapter 5 Regulation of Cytoplasmic pH in Bacteria	65	(14)
D. McLaggan
J. Stephen
I.R. Booth
Chapter 6 Vertebrate Hormones in Bacteria and Microbial Eukaryotes	79	(6)
John Lenard
Chapter 7 Principles of Bacterial Pathogenesis	85	(14)
Daniel C. Stein
Chapter 8 Selected Bacteria of Medical Importance	99	(48)
Ronald J. Siebeling
Chapter 9 Tuberculosis	147	(10)
Peter Zwadyk
Chapter 10 Mycobacterium Avium-Intracellulare (MAI)	157	(10)
Gwen A. Huitt
James L. Cook
Chapter 11 Hansen Disease	167	(8)
Thomas M. Shinnick
Chapter 12 Antimicrobial Therapy	175	(24)
Charles A. Peloquin
Chapter 13 Mechanisms of Resistance to Antibacterial Agents	199	(16)
Robert C. Cooksey
Chapter 14 Lyme Disease	215	(18)
Leonard H. Sigal
Chapter 15 Syphilis	233	(12)
John Richens
Chapter 16 Brucellosis	245	(12)
S.G. Wright
Chapter 17 Fungal Diseases	257	(30)
Judith E. Domer
Chapter 18 The Rickettsiae	287	(32)
Karim E. Hechemy
Chapter 19 Chlamydia	319	(10)
Lisa A. Jackson
J. Thomas Grayston
Volume 9B
List of Contributors	xi	(8)
Preface	xix
E. Edward Bittar
Neville Bittar
Chapter 20 Viral Membranes	329	(24)
David A. Steinhauer
Don C. Wiley
John J. Skehel
Chapter 21 Principles of Retrovirus Assembly	353	(12)
Maja A. Sommerfelt
Eric Hunter
Chapter 22 Virus-Induced Alterations in Cells	365	(16)
Juan Carlos de la Torre
Persephone Borrow
Chapter 23 Retroviral Vectors	381	(12)
A.M.L. Lever
Chapter 24 Herpesviruses	393	(22)
J. Barklie Clements
S. Moira Brown
Chapter 25 Respiratory Tract Viruses	415	(24)
Christopher William Potter
Chapter 26 The Interferons	439	(14)
Samuel Baron
Chapter 27 Genetics and Molecular Biology of AIDS Virus	453	(26)
Michael Westby
Angus G. Dalgleish
Chapter 28 AIDS Epidemiology in the United States	479	(14)
Susan P. Buchbinder
Nancy A. Hessol
Chapter 29 The Global Epidemiology of AIDS	493	(16)
G.R. Kinghorn
Chapter 30 Diagnostic Virology	509	(20)
Thomas F. Smith
Chapter 31 Antiviral Chemotherapy	529	(22)
Michael Keating
Chapter 32 From Jenner to Genes--The Next Generation of Virus Vaccines	551	(12)
Fred Brown
Chapter 33 Principles of Parasitology and Parasitic Disorders	563	(34)
Brian R. Shiels
Chapter 34 The Molecular Epidemiology of Parasites	597	(18)
Geoff Hide
Chapter 35 Chemotherapeutic Agents Used in Tropical Medicine	615	(16)
G.C. Cook
Chapter 36 Toxin-Induced Diseases	631	(30)
John H. Freer
Chapter 37 The Pathogenesis of Sepsis	661	(14)
David Simon
Larry J. Goodman
Roger C. Bone
Chapter 38 Bacterial Meningitis	675	(12)
Carole A. Sable
W. Michael Scheld
Chapter 39 Fever of Unknown Origin in the General Population and in HIV-Infected Persons	687	(18)
Wendy Armstrong
Powel Kazanjian
Index	705