Prostate Cancer : Biology, Genetics and the New Therapeutics

by Chung, Leland W.K.

• ISBN13: 9780896038684
• ISBN10: 0896038688
• eBook ISBN(s): 9781592590094
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-01-01
• Publisher: Humana Pr Inc

Summary

Leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer and its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer, and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth and progression has revealed many new possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Comprehensive and cutting-edge, Prostate Cancer: Biology, Genetics, and the New Therapeutics synthesizes all the major recent work that is not only rapidly unraveling the mysteries of prostate cancer, but also dramatically improving today's therapeutic approaches.

Table of Contents

Donald S. Coffey	p. viii
Preface	p. ix
List of Contributors	p. xv
Introduction
Building the Road to Defeat Prostate Cancer: A Dedication to Donald S. Coffey	p. 3
Cancer Genetics
Hereditary Prostate Cancer	p. 13
AR Gene Alterations in Prostate Cancer Progression	p. 29
Lethal Metastatic Human Prostate Cancer: Autopsy Studies and Characteristics of Metastases	p. 39
Tumor Suppressor Genes in Prostate Cancer	p. 61
Androgen Receptor Polymorphisms and Prostate Cancer Risk	p. 95
The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease	p. 111
Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques	p. 123
Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN)	p. 141
Xenograft Models and the Molecular Biology of Human Prostate Cancer	p. 163
Comprehensive Analyses of Prostate Gene Expression	p. 175
Cancer Biology
The Role of Nuclear Matrix and Cytoskeleton in Cancer	p. 193
The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis	p. 207
Ligand Dependent and Independent Activation of the Androgen Receptor	p. 219
Tyrosine Kinases and Cellular Signaling in Prostate Cancer	p. 241
Molecular Pathways Underlying Prostate Cancer Progression: The Role of Caveolin-1	p. 267
Angiogenesis and Prostate Cancer	p. 279
Prostate Specific Membrane Antigen	p. 307
Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen- and Chemo-Sensitivity in Prostate Cancer	p. 327
Stromal-Epithelial Interaction: From Bench to Bedside	p. 341
Cancer Therapeutics
Chemoprevention of Prostate Cancer	p. 365
Anatomic Radical Retropubic Prostatectomy for Prostate Cancer	p. 377
Radiation Therapy as Applied to Prostate Cancer: Clinical, Technical, and Biologic Considerations	p. 387
Prostate Cancer Chemotherapy: Closing Out a Century and Opening a New One	p. 415
The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer	p. 433
Development of Dendritic Cell-Based Prostate Cancer Vaccine	p. 449
Antiprogression Agents for Prostate Cancer	p. 461
Human Gene Therapy for Urological Oncology	p. 483
Chemoprevention Trials for Prostate Cancer	p. 499
Index	p. 519
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