Proton Therapy Physics

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2011-12-13
  • Publisher: CRC Press

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Compared to x-ray-based radiotherapeutic modalities, proton therapy provides greater 3D localization, higher beam doses, access to deeper tumors, and less damage to surrounding healthy tissue. Though over fifty years old, it is now coming to the forefront of cancer treatment with greater understanding of the biophysics and better treatment and patient outcomes. This text presents an overview of proton therapy that addresses all key topics including, biophysics, accelerators, hardware, beam delivery, treatment planning, dose calculation, quality assurance, and precision.

Table of Contents

About the Seriesp. vii
The International Organization for Medical Physicsp. ix
Introductionp. xi
Editorp. xvii
Contributorsp. xix
Proton Therapy: History and Rationalep. 1
Physics of Proton Interactions in Matterp. 19
Proton Acceleratorsp. 61
Characteristics of Clinical Proton Beamsp. 103
Beam Delivery Using Passive Scatteringp. 125
Particle Beam Scanningp. 157
Dosimetryp. 191
Quality Assurance and Commissioningp. 221
Monte Carlo Simulationsp. 265
Physics of Treatment Planning for Single-Field Uniform Dosep. 305
Physics of Treatment Planning Using Scanned Beamsp. 335
Dose Calculation Algorithmsp. 381
Precision and Uncertainties in Proton Therapy for Nonmoving Targetsp. 413
Precision and Uncertainties in Proton Therapy for Moving Targetsp. 435
Treatment-Planning Optimizationp. 461
In Vivo Dose Verificationp. 489
Basic Aspects of Shieldingp. 525
Late Effects from Scattered and Secondary Radiationp. 555
The Physics of Proton Biologyp. 593
Fully Exploiting the Benefits of Protons: Using Risk Models for Normal Tissue Complications in Treatment Optimizationp. 627
Indexp. 653
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