Recombinant DNA: Genes and Genomes A Short Course

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  • Edition: 3rd
  • Format: Paperback
  • Copyright: 2006-12-08
  • Publisher: W. H. Freeman

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Recombinant DNA, Third Edition, is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics. The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.

Author Biography

James D. Watson, co-winner of the Nobel prize for discovering the DNA double helix, is Chancellor of the Cold Spring Harbor Laboratory. Jan A. Witkowski is Executive Director of the Banbury Center and Professor in the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. Richard M. Myers is Chairman and Stanford W. Ascherman Professor in the Department of Genetics at Stanford University, and is Director of the Stanford Human Genome Center. Amy A. Caudy is the Lewis-Stiger Fellow at the Lewis-Stiger Institute for Integrative Genomics at Princeton University.

Table of Contents

DNA is the primary genetic materialp. 3
Information flow from DNA to proteinp. 29
Control of gene expressionp. 53
Basic tools of recombinant DNAp. 75
Fundamental features of eukaryotic genesp. 107
A new toolbox for recombinant DNAp. 129
Mobile DNA sequences in the genomep. 159
Epigenetic modifications of the genomep. 189
RNA interference regulates gene actionp. 219
Fundamentals of whole-genome sequencingp. 249
How the human genome was sequencedp. 273
Comparing and analyzing genomesp. 311
From genome sequence to gene functionp. 335
Finding human disease genesp. 365
Understanding the genetic basis of cancerp. 395
DNA fingerprinting and forensicsp. 431
Table of Contents provided by Blackwell. All Rights Reserved.

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