9780833026767

A Review of the Scientific Literature As It Pertains to Gulf War Illnesses: Infectious Diseases

by
  • ISBN13:

    9780833026767

  • ISBN10:

    0833026763

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2000-12-01
  • Publisher: RAND CORPORATION

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Summary

Numerous Gulf War veterans have reported a range of illnesses and symptoms after serving in the Persian Gulf. Some of the reported symptoms are similar to those caused by diseases known to be prevalent in that region. This report discusses these infectious diseases and considers them as potential causes of the symptoms reported by the veterans. The authors present a short summary of etiology, diagnosis, and treatment for several infectious diseases and infectious organisms, including bacterial, viral, and parasitic infections. Two biological agents--anthrax and botulinum toxin--are also discussed.

Table of Contents

Preface v
Figure
xiii
Tables
xv
Summary xvii
Acknowledgments xxi
Introduction
1(10)
Background
1(1)
Purpose
2(1)
Organization of This Document
2(1)
Overview of What We Know About Diseases
2(2)
Common Illnesses in Gulf War Veterans
4(2)
Infectious Diseases in Gulf War Troops
6(2)
Gastrointestinal Diseases
6(1)
Respiratory Diseases
6(1)
Other Diseases
7(1)
Infectious Diseases in the Persian Gulf But Not Identified in Gulf War Troops
8(1)
Other Infectious Diseases Considered
8(3)
Infectious Diseases as a Possible Cause of Gulf War Illnesses
11(4)
Reasons to Consider an Infectious Etiology
11(1)
Epidemiologic Relationship
11(1)
History of Infectious Diseases
11(1)
Some Infectious Diseases Were Identified
12(1)
Reasons to Dismiss an Infectious Etiology
12(3)
Koch's Postulates
12(1)
A Missing Specific Finding
13(1)
Some Evidence Does Not Fit
13(2)
Bacterial Diseases (Mycoplasma)
15(16)
Background on Mycoplasmas
15(2)
Mycoplasma and Disease in Those with Dysfunctional Immune Systems
16(1)
Mycoplasma and Disease in Those with Normal Immune Function
16(1)
Mycoplasma in Gulf War Veterans
17(1)
Evaluating Elements of the Mycoplasma Hypothesis
17(14)
Origin
18(3)
Testing of Veterans for Mycoplasma
21(2)
Theoretical Compatibility of Mycoplasma Infection with Symptoms in Gulf War Veterans
23(2)
Evidence of Mycoplasma in Ill Gulf War Veterans
25(1)
Treatment of Veterans with Antibiotics
26(1)
Correlation with Gulf War Illnesses
27(1)
Summary
28(3)
Bacterial Diseases (Other Than Mycoplasma)
31(16)
Typhoid Fever
31(2)
Introduction
31(1)
What Infected Patients Experience
31(1)
Diagnosis
32(1)
Prevention
32(1)
Correlation with Gulf War Illnesses
32(1)
Summary
32(1)
Mycobacteria Tuberculosis
33(2)
Introduction
33(1)
Epidemiologic Information
33(1)
What Infected Patients Experience
33(1)
Diagnosis
34(1)
Treatment and Prevention
34(1)
Correlation with Gulf War Illnesses
34(1)
Summary
34(1)
Enteric Agents: Enterotoxigenic E. Coli, Campylobacter, Shigella, and Other Salmonella
35(3)
Introduction
35(1)
Epidemiologic Information
35(1)
What Infected Patients Experience
35(2)
Diagnosis
37(1)
Treatment and Prevention
37(1)
Correlation with Gulf War Illnesses
37(1)
Summary
38(1)
Meningococcus
38(3)
Introduction
38(1)
Epidemiologic Information
38(1)
What Infected Patients Experience
38(1)
Diagnosis
39(1)
Treatment and Prevention
40(1)
Correlation with Gulf War Illnesses
40(1)
Summary
40(1)
Brucella
41(3)
Introduction
41(1)
Epidemiologic Information
41(1)
What Infected Patients Experience
42(1)
Diagnosis
42(1)
Prevention
43(1)
Correlation with Gulf War Illnesses
43(1)
Summary
43(1)
Cholera
44(3)
Introduction
44(1)
Epidemiologic Information
44(1)
What Infected Patients Experience
44(1)
Diagnosis
44(1)
Treatment and Prevention
45(1)
Correlation with Gulf War Illnesses
45(1)
Summary
45(2)
Viral Diseases
47(22)
Viral Hepatitis
47(4)
Introduction
47(1)
Epidemiologic Information
47(1)
What Infected Patients Experience
48(1)
Diagnosis
49(1)
Treatment and Prevention
49(1)
Correlation with Gulf War Illnesses
50(1)
Summary
50(1)
Crimean-Congo Hemorrhagic Fever
51(2)
Introduction
51(1)
Epidemiologic Information
51(1)
What Infected Patients Experience
51(1)
Diagnosis
52(1)
Treatment and Prevention
52(1)
Correlation with Gulf War Illnesses
52(1)
Summary
52(1)
West Nile Fever
53(2)
Introduction
53(1)
Epidemiologic Information
53(1)
What Infected Patients Experience
54(1)
Diagnosis
54(1)
Treatment and Prevention
54(1)
Correlation with Gulf War Illnesses
54(1)
Summary
54(1)
Sindbis
55(2)
Introduction
55(1)
Epidemiologic Information
55(1)
What Infected Patients Experience
55(1)
Diagnosis
56(1)
Treatment and Prevention
56(1)
Correlation with Gulf War Illnesses
56(1)
Summary
56(1)
Rift Valley Fever
57(2)
Introduction
57(1)
Epidemiologic Information
57(1)
What Infected Patients Experience
57(1)
Diagnosis
58(1)
Treatment and Prevention
58(1)
Correlation with Gulf War Illnesses
58(1)
Summary
58(1)
Rabies
59(2)
Introduction
59(1)
Epidemiologic Information
59(1)
What Infected Patients Experience
60(1)
Diagnosis
60(1)
Treatment and Prevention
60(1)
Correlation with Gulf War Illnesses
60(1)
Summary
61(1)
Dengue
61(2)
Introduction
61(1)
Epidemiologic Information
62(1)
What Infected Patients Experience
62(1)
Diagnosis
62(1)
Treatment and Prevention
63(1)
Correlation with Gulf War Illnesses
63(1)
Summary
63(1)
Sandfly Fever
63(3)
Introduction
63(1)
Epidemiologic Information
64(1)
What Infected Patients Experience
64(1)
Diagnosis
65(1)
Treatment and Prevention
65(1)
Correlation with Gulf War Illnesses
65(1)
Summary
65(1)
Leishmaniavirus
66(3)
Introduction
66(1)
Epidemiologic Information
66(1)
What Infected Patients Experience
66(1)
Diagnosis
66(1)
Treatment and Prevention
67(1)
Correlation with Gulf War Illnesses
67(1)
Summary
67(2)
Parasitic Diseases
69(20)
Leishmaniasis
69(7)
Introduction
69(1)
Epidemiologic Information
70(1)
What Infected Patients Experience
71(1)
Diagnosis
72(1)
Treatment and Prevention
73(1)
Correlation with Gulf War Illnesses
73(3)
Summary
76(1)
Malaria
76(4)
Introduction
76(1)
Epidemiologic Information
77(1)
What Infected Patients Experience
77(1)
Diagnosis
78(1)
Treatment and Prevention
78(1)
Correlation with Gulf War Illnesses
79(1)
Summary
79(1)
Giardia
80(2)
Introduction
80(1)
Epidemiologic Information
80(1)
What Infected Patients Experience
80(1)
Diagnosis
81(1)
Treatment and Prevention
81(1)
Correlation with Gulf War Illnesses
82(1)
Summary
82(1)
Amoeba
82(3)
Introduction
82(1)
Epidemiologic Information
83(1)
What Infected Patients Experience
83(1)
Diagnosis
84(1)
Treatment and Prevention
84(1)
Correlation with Gulf War Illnesses
85(1)
Summary
85(1)
Schistosomiasis
85(4)
Introduction
85(1)
Epidemiologic Information
86(1)
What Infected Patients Experience
86(1)
Diagnosis
87(1)
Treatment and Prevention
87(1)
Correlation with Gulf War Illnesses
88(1)
Summary
88(1)
Biological Warfare Agents
89(4)
Anthrax
89(1)
Introduction
89(1)
What Infected Patients Experience
90(1)
Prevention
90(1)
Botulinum Toxin
90(2)
Introduction
90(1)
Epidemiologic Information
91(1)
What Infected Patients Experience
91(1)
Summary
92(1)
Unidentified Infections
93(4)
General Processes for Identification
93(1)
Representational Difference Analysis (RDA)
94(1)
Serial Analysis of Genomic Expression (SAGE)
94(1)
CDNA Expression Analysis
94(3)
Conclusions and Recommendations
97(2)
Appendix: Additional Consideration On Mycoplasma 99(4)
Bibliography 103

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