Rna Regulation

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  • Format: Hardcover
  • Copyright: 2014-03-17
  • Publisher: Wiley-Blackwell
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Based on one of the leading encyclopedic resources in cell and molecular biology worldwide, this two-volume work contains more than 75% new content, not previously published in the Encyclopedia. All the other chapters have been carefully updated.
The result is a comprehensive overview of the different functions of the various forms of RNA in living organisms, with each contributor carefully selected and an internationally recognized expert on his or her field. Special focus is on the different forms of expression regulation through RNA, with medical applications in the treatment of diseases -- from cancers and immune responses to infections and aging -- covered in detail. At least 45 of the 55 articles are new content previously not published in the Encyclopedia.

Author Biography

Dr. Robert A. Meyers, the Editor in Chief (EiC) of the Encyclopedia of Cell and Molecular Biology and Molecular Medicine, originated the Encyclopedia and continues responsibility for the project.
Dr. Meyers has a Ph.D. in organic chemistry from UCLA and was a postdoctoral and faculty member at the California Institute of Technology. He is president of Ramtechlimited and is author or editor in chief of an additional twelve books and 20 technical papers as well as ten patents.

Table of Contents

I Bioinformatic and Computational Methods

RNA-regulatory networks Integrative Modeling
Robert B. Darnell Rockefeller U

II Medical Applications

Regulation in Aging
Myriam Gorospe NIH NIAging
Cancer miRNAs in Cancer
Scott Hammond University of North Carolina at Chapel Hill
Cancer Non-Protein-Coding RNAs (ncRNAs) at Gene Promoter Regions in Cancer
David Corey UT Southwestern
Cancer Translation regulation by microRNAs in leukemia
Shobha Vasudevan Massachusetts General Hospital, Harvard Medical School
General Pharmacology and Emerging Clinical Application of RNA
Barik, Sailen University of South Alabama
Hepatitis Infection RNAi to Treat Chronic Hepatitis B Virus Infection
Arbuthnot P University of the Witwatersrand Medical School,
Hepatitis Infection RNAi to Treat Chronic Hepatitis C Infection
Linda Couto Childrens Hospital of Philadelphia
HIV Infection RNAi Gene Therapy to Control HIV-1 Infection
Ben Berkhout and Olivier ter Brake University of Amsterdam
Immunity RNA responses to cell stress in the immune response
Paul Anderson Harvard Medical School
Immunity RNA-based immune regulators
Jens Lykke-Andersen University of California ? San Diego
Infections Cellular miRNAs in Mammalian Antiviral Immune Responses
Joost Haasnoot and Ben Berkhout University of Amsterdam
Infections Virally Encoded miRNAs
Thomas Tuschl Rockefeller U

III Methods for Analysis and Manipulation of RNA-mediated Regulation

Characterization RNA Methodologies
Farrell, Jr., Robert E. Penn State University
Vectors Bacterial Vectors for RNAi Delivery
Johannes H. Fruehauf Harvard Medical School
Vectors Lipid-like molecules for Delivery of RNAi to cells.
Robert Langer MIT
Vectors Nanoparticles for Small Interfering RNA Delivery
Daniel G. Anderson MIT
Vectors RNAi Delivery with Viral Vectors
Robbins PD University of Pittsburgh School of Medicine
Vectors RNAi Delivery Optimization
John Rossi Beckman Research Institute of the City of Hope
Characterization RNAi Screening and Assays
Christophe J. Echeverri Cenix BioScience GmbH

IV Molecular Cell Biology

Antisense Antisense-RNA regulation
Sabine Brantl Friedrich Schiller Univ. Jena
Apoptosis RNA regulation in apoptosis
Imed Gallouzi McGill University, Canada
Bacteria Bacterial tmRNA regulation of the cell cycle and developmental process
Kenneth Keiler Pennsylvania State University
Bacteria Small regulatory non-coding RNAs in bacteria
Francis Repoila INSERM
Core Article Regulation of Gene Expression
Anil Kumar Devi Ahilya University
Developmental miRNAs (Micro RNAs) in Developmental Processes
Frank J. Slack Yale U
Developmental miRNA-targeted mRNAs that control cellular differentiation pathways
Amy Pasquinelli University of California, San Diego
Developmental RNA Regulation in Myogenesis
Roberto Gherzi University of Genoa, Italy
Developmental RNA Silencing in Periconception
Deborah Bourc'his CNRS Paris
Function Large Intergenic Noncoding RNAs (lincRNAs)
John L. Rinn Beth Israel Deaconess Medical Center and Harvard Medical School
Function Non-coding RNAs in imprinted gene clusters
Jerome Cavaille LBME-CNRS
Function Non-coding RNAs regulating the transcriptional machinery
Olivier Bensaude CNRS Ecole Normale Superieure
Function Non-Protein-Coding RNAs (ncRNAs) in Chromatin Function
Eran Segal Weizmann Institute of Science
Function Ribonome and Gene Expression
Jack D. Keene Duke University Medical Center
Function Riboswitches in Gene Regulation
Tina M. Henkin Ohio State University
Function RNA Editing and Nucleotide Modification
Eric M. Phizicky University of Rochester Medical Center
Function RNA Interference in the Nucleus
Gunter Meister Max Planck Institute of Biochemistry, Martinsried
Function Translate or to Degrade a Cytoplasmic mRNA Decision Mechanism
Ann-Bin Shyu University of Texas, Medical School
Fundamental Processes RNA-induced initiation of transcriptional silencing (RITS) Complex Structure and Functions
Robert A. Martienssen Cold Spring Harbor
Fundamental Processes RNA-Induced Silencing Complex (RISC) Structure and Functions
Erik J. Sontheimer Northwestern University
Insects RNAi Based Antiviral Immune System in Insects
Maria-Carla Saleh Pasteur Institute
Insects RNA-Mediated Gene Regulation in Drosophila
Richard Morgan National Institutes of Health
Plants RNA silencing Cell to Cell movement in plants
Kriton Kalantidis Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology -
Plants RNA Silencing in Plants
David Baulcombe University of Cambridge
Silencing dsRNA mediated gene silencing process
Andrew Z. Fire Stanford University
Silencing Gene Knockdown in Mice with siRNA
Inder M. Verma Salk Institute
Stability RNA stability in mammalian cells
Ann-Bin Shyu University of Texas -
Houston Medical School
Stem Cells RNA Induced Pluripotent Stem Cells (RiPS)
Doug Melton Harvard Stem Cell Insitute
Structure RNA as a Regulator of Chromatin Structure
Antonio Rodriguez-Campos Institute of Molecular Biology of Barcelona (IBMB),
Transport Direct Visualization of RNA transport and localization of specific RNAs within individual cells
Robert H. Singer Albert Einstein College of Medicine
Transport mRNP (messenger ribonucleoprotein) export to the Cytoplasm
Domenico Libri CNRS
Transport Nuclear Export and Maturation of Ribosomes
Arlen W. Johnson University of Texas at Austin
Transport siRNAs Transport from the Cytoplasm to the Nucleus
Scott Kennedy University of Wisconsin?Madison
Transport tRNA Subcellular Dynamics
Anita T. Hopper Ohio State University
Viruses RNA regulatory processes in viruses
Jeff Wilusz Colorado State University

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