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9781573315685

Inflammatory Bowel Disease Genetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072

by ; ; ; ;
  • ISBN13:

    9781573315685

  • ISBN10:

    1573315680

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2006-10-02
  • Publisher: Wiley-Blackwell
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Summary

Inflammatory bowel disease (IBD), which encompasses both Crohn's disease and ulcerative colitis, is a chronically relapsing intestinal disorder that is characterized by diarrhea and abdominal pain.The incidence of IBD is increasing worldwide. Although some major advances have been made in recent years, the pathogenesis of the disease still remains obscure. As currently understood, a combination of genetic alterations and immunological disturbances causing an interaction of the enteric microflora with the underlying mucosa and a disrupted barrier function may be crucial for the development of disease.Despite substantial new data that have been obtained over the last several years, it has become increasingly difficult to accommodate these into a unifying disease model. Identification of pro- and anti-inflammatory cytokines has introduced "biologic therapies," but treatment of IBD is still based mainly on broad-spectrum immunosuppressive drugs such as steroids and azathioprine. In this volume, the most relevant pathogenetic aspects are stressed: genetic alterations, disrupted epithelial barrier function, immunological disturbances, and the role of the enteric microflora.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Wolfram W. Domschke and Martin F Kagnoff are the authors of Inflammatory Bowel Disease: Genetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072, published by Wiley.

Table of Contents

Preface.
By WOLFRAM W. DOMSCHKE, MARTIN F. KAGNOFF, TORSTEN F. KUCHARZIK, LLOYD F. MAYER, AND STEPHAN R. TARGAN
xi
Opening Lecture
Current Limitations of IBD Treatment: Where Do We Go from Here?
By STEPHAN R. TARGAN
1(8)
Part I. Genetics
CARD15/NOD2 Mutations in Crohn's Disease.
By JEAN-PIERRE HUGOT
9(10)
Innate Immune Sensing of Microbes By Nod Proteins.
By THOMAS A. KUFER, DIANA J. BANKS, AND DANA J. PHILPOTT
19(9)
Part II. Immunologic Mechanisms
Animal Models of Inflammatory Bowel Disease: Lessons from Enteric Infections.
By LARS ECKMANN
28(11)
Molecular Approaches to the Role of the Microbiota in Inflammatory Bowel Disease.
By CHARLES O. ELSON, YINGZI CONG, FENGXTA QI, ROBERT M. HERSHBERG, AND STEPHAN R. TARGAN
39(13)
CCR6 and CCL20: Partners in Intestinal Immunity and Lymphorganogenesis.
By IFOR R. WILLIAMS
52(10)
Apoptosis as a Therapeutic Tool in IBD?
By ANDREAS LÜGERING, PIA LEBIEDZ, STEFAN KOCH, AND TORSTEN KUCHARZIK
62(16)
The Intestinal Microvasculature as a Therapeutic Target in Inflammatory Bowel Disease.
By OSSAMA A. HATOUM, JAN HEIDEMANN, AND DAVID G. BINION
78(20)
Novel Signal Transduction Pathways: Analysis of STAT-3 and Rac-1 Signaling in Inflammatory Bowel Disease.
By R. ATREYA, I. ATREYA, AND M.F. NEURATH
98(16)
NF-kappaB Signaling: Pros and Cons of Altering NF-kappaB as a Therapeutic Approach.
By LAURENCE J. EGAN AND MURAT TORUNER
114(9)
Role of the Melanocortin System in Inflammation.
By CHRISTIAN MAASER, KLAUS KANNENGIESSER, AND TORSTEN KUCHARZIK
123(12)
Immunology of Crohn's Disease.
By HENRI BRAAT, MAIKEL P. PEPPELENBOSCH, AND DAAN W. HOMMES
135(20)
Role of CEACAM1 as a Regulator of T Cells.
By TAKASHI NAGAISHI, HIDEKI IIJIMA, ATSUSHI NAKAJIMA, DAOHONG CHEN, AND RICHARD S. BLUMBERG
155(21)
Therapeutic Drug Delivery By Genetically Modified Lactococcus lactic.
By LOTHAR STEIDLER AND PIETER ROTTIERS
176(11)
Role of Lymphotoxins in the Development of Peyer's Patches and Mesenteric Lymph Nodes: Relevance to Intestinal Inflammation and Treatment.
By THOMAS W. SPAHN, MICHAEL K. MÜLLER, WOLFRAM DOMSCHKE, AND TORSTEN KUCHARZIK
187(7)
Immunomodulatory Roles of the Carcinoembryonic Antigen Family of Glycoproteins.
By LING SHAO, MATTHIEU ALLEZ, MEE-SOOK PARK, AND LLOYD MAYER
194(16)
Induction of Intestinal Lymphoid Tissue: The Role of Cryptopatches.
By ANDREAS LÜGERING AND TORSTEN KUCHARZIK
210(8)
Peyer's Patches and M Cells as Potential Sites of the Inflammatory Onset in Crohn's Disease.
By ELISABET GULLBERG AND JOHAN D. SÖDERHOLM
218(15)
Synergistic Costimulation By Both B7 Molecules Regulates Colitis Pathogenesis.
By GISEN KIM, STEPHEN P. SCHOENBERGER, ARLENE SHARPE, AND MITCHELL KRONENBERG
233(9)
Part III. Barrier Function
Inflammatory Bowel Disease and the Apical Junctional Complex.
By MATTHIAS BRUEWER, STANISLAV SAMARIN, AND ASMA NUSRAT
242(11)
Antibody-Mediated Antigen Sampling across Intestinal Epithelial Barriers.
By M. CECILIA BERIN, HONGXING LI, AND KIRK SPERBER
253(9)
Molecular Mechanisms of Disturbed Electrolyte Transport in Intestinal Inflammation.
By URSULA SEIDLER, HENRIKE LENZEN, AYHAN CINAR, TESFAYE TESSEMA, ANDRÉ BLEICH, AND BRIGITTE RIEDERER
262(14)
Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD: Potential Targets for Inhibiting Neutrophil Trafficking.
By ALEX C. CHIN AND CHARLES A. PARKOS
276(12)
Disrupted Barrier Function through Epithelial Cell Apoptosis.
By JOERG-DIETER SCHULZKE, CHRISTIAN BOJARSKI, SEBASTIAN ZEISSIG, FRANK HELLER, ALFRED H. GITTER, AND MICHAEL FROMM
288(12)
Growth Factors as Treatment Options for Intestinal Inflammation.
By BRIAN K. DIECKGRAEFE, JOSHUA R. KORZENIK, AND SHRIKANT ANANT
300(7)
Part IV. Microbial Pathways
The Bacterial Weaponry: Lessons from Shigella.
By PHILIPPE J. SANSONETTI
307(6)
Microbial-Epithelial Cell Crosstalk during Inflammation: The Host Response.
By MARTIN F. KAGNOFF
313(8)
A New Look at Crohn's Disease: Breakdown of the Mucosal Antibacterial Defense.
By JAN WEHKAMP AND EDUARD F. STANGE
321(11)
Toll-Like Receptor Signaling and its Relevance to Intestinal Inflammation.
By ELKE CARIO AND DANIEL K. PODOLSKY
332(7)
Probiotics: Do They Help to Control Intestinal Inflammation?
By S.K. BÖHM AND W. KRUIS
339(12)
Homeostatic Effects of TLR9 Signaling in Experimental Colitis.
By JONGDAE LEE, DANIEL RACHMILEWITZ, AND EYAL RAZ
351(5)
Helminths and Mucosal Immune Modulation.
By JOEL V. WEINSTOCK
356(9)
Concluding Lecture
Inflammatory Bowel Disease: Pandora's Box, Present and Future.
By JÜRGEN SCHÖLMERICH
365(14)
Part V. Short Communications
High Diagnostic Value of 18F–FDG–PET in Pediatric Patients with Chronic Inflammatory Bowel Disease.
By M. LÖFFLER, M. WECKESSER, C. FRANZIUS, O. SCHOBER, AND K.-P. ZIMMER
379(7)
Role of Macrophage Metalloelastase in Gut Inflammation.
By SYLVIA L.F. PENDER, C.K.F. LI, A.D.I. SABATINO, T.T. MACDONALD, AND M.G. BUCKLEY
386(3)
IL-10 Gene-Deficient Mice Lack TGF-Beta/Smad-Mediated TLR2 Degradation and Fail to Inhibit Proinflammatory Gene Expression In Intestinal Epithelial Cells under Conditions of Chronic Inflammation.
By PEDRO A. RUIZ, ANNA SHKODA, SANDRA C. KIM, R. BALFOUR SARTOR, AND DIRK HALLER
389(6)
Perinodal Adipose Tissue and Fatty Acid Composition of Lymphoid Tissues in Patients with and without Crohn's Disease and Their Implications for the Etiology and Treatment of CD.
By EDWARD D.A. WESTCOTT, CHRISTINE A. MATTACKS, ALASTAIR C.J. WINDSOR, STELLA C. KNIGHT, AND CAROLINE M. POND
395(6)
Intestinal Epithelial Antigen Induces CD4+ T Cells with Regulatory Phenotype in a Transgenic Autoimmune Mouse Model.
By ASTRID M. WESTENDORF, DUNJA BRUDER, WIEBKE HANSEN, AND JAN BUER
401(6)
Toll-Like Receptor Expression and Response to Specific Stimulation in Adipocytes and Preadipocytes: On the Role of Fat in Inflammation.
By J. PIETSCH, A. BATRA, T. STROH, I. FEDKE, R. GLAUBEN, B. OKUR, M. ZEITZ, AND B. SIEGMUND
407(4)
Index of Contributors 411

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