9781449613396

The World's leading experts provide all the 'Essentials' needed to manage patients in the office, on the ward and in the ICU. HIV Essentials 2011 incorporates the latest clinical guidelines into a step-by-step guide to the diagnosis, evaluation, management and prevention of HIV infection and its complications.

Topics include:

-HIV diagnosis, evaluation, treatment and prevention

-Opportunistic infections and other HIV Complications

-Treatment of HIV and pregnancy

-Antiretroviral drug summaries

-Post-exposure Prophylaxis

-New section to each drug summary called "How Supplied" describes the commercially available dosage forms for all the ARV's

''Clinicians are constantly faced with changes in this field. This update maintains its friendly format and layout, it is well written, and the information is easy to access and understand. The authors are national experts who also provide invaluable opinion based on their experience. Ideally, readers should use the outlined key references to the literature to expand on certain topics and obtain more detailed information. This book proves its usefulness once again as a pocket reference for providers and busy clinicians managing patients with HIV infection.'' -Uriel Sandkovsky, MD,University of Nebraska Medical Center

Overview of HIV Infection	p. 1
Overview	p. 2
Stages of HIV Infection	p. 3
Acute HIV Infection	p. 4
Differential Diagnosis	p. 4
Signs and Symptoms	p. 4
Laboratory Findings	p. 4
Diagnostic Testing	p. 5
Management	p. 5
Diagnosis and Evaluation of HIV Infection	p. 6
HIV Antibody Testing	p. 7
ELISA	p. 7
Western Blot	p. 7
Others	p. 7
HIV Viral Load Assays	p. 9
Uses	p. 9
Assays and Interpretation	p. 9
Indications	p. 11
Initial Assessment of HIV-Infected Patients	p. 11
Clinical Evaluation	p. 11
Laboratory Testing	p. 12
CD4 Cell Count	p. 14
Treatment of HIV Infection	p. 15
Initiation of Antiretroviral Therapy	p. 16
Selection of an Optimal Initial Antiretroviral Regimen	p. 22
Complications of HIV Therapy	p. 31
Lipodystrophy Syndrome	p. 31
Antiretroviral Therapy Adverse Effects	p. 35
Bleeding Events	p. 36
Bone Marrow Suppression	p. 36
Cardiovascular	p. 38
Central Nervous System	p. 39
Gastrointestinal Intolerance	p. 40
Hepatic Failure	p. 41
Hepatoxicity	p. 43
Hyperlipidemia	p. 45
Hypersensitivity Reaction	p. 47
Insulin Resistance/Diabetes Mellitus	p. 49
Lactic Acidosis/Hepatic Steatosis	p. 50
Lipodystrophy	p. 53
Nephrolithiasis/Urolithiasis/Crystalluria	p. 54
Nephrotoxicity	p. 55
Neuromuscular Weakness Syndrome	p. 57
Osteonecrosis	p. 58
Osteopenia	p. 59
Pancreatitis	p. 60
Peripheral Neuropathy	p. 60
Stevens-Johnson Syndrome	p. 61
References and Suggested Readings	p. 64
Treatment Failure and Resistance Testing	p. 66
Antiretroviral Treatment Failure	p. 67
Virologic Failure	p. 67
Immunologic Failure	p. 68
Clinical Failure	p. 68
Usual Sequence of Treatment Failure	p. 68
Principles of Resistance Testing	p. 72
Types of Resistance Testing	p. 73
Genotype Testing	p. 74
Phenotype Testing	p. 74
Other Options for Resistance Testing	p. 75
Co-Receptor Tropism Assay	p. 75
Indications for and Approach to Resistance Testing	p. 75
Important Genotype-Resistant Patterns	p. 77
Nucleoside Reverse Transcriptase Inhibitors (NRTI's)	p. 77
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI's)	p. 77
Protease Inhibitors (Pi's)	p. 79
Prophylaxis and Treatment of Opportunistic Infections	p. 82
Prophylaxis of Opportunistic Infections	p. 83
Treatment of Opportunistic Infections	p. 90
Aspergillosis, Invasive	p. 91
Bacterial Respiratory Diseases	p. 92
Bartonella Infections	p. 94
Campylobacteriosis	p. 95
Candidiasis (Mucosal)	p. 95
Chagas Disease	p. 98
Clostridium difficile Diarrhea/Colitis	p. 98
Coccidioidomycosis	p. 99
Cryptococcal Meningitis	p. 100
Cryptosporidiosis	p. 102
Cytomegalovirus (CMV) Disease	p. 103
Hepatitis B Virus (HBV)	p. 106
Hepatitis C Virus (HCV)	p. 108
Herpes Simplex Virus (HSV) Disease	p. 113
HHV-6 Infection	p. 114
HHV-8 Infection	p. 115
Histoplasma capsulatum	p. 115
Human Papillomavirus (HPV) Disease	p. 117
Isospora belli Infection	p. 118
Leishmaniasis, Cutaneous	p. 119
Leishmaniasis, Visceral	p. 119
Malaria	p. 120
Malaria, Severe	p. 120
Malaria, Uncomplicated	p. 121
Microsporidiosis	p. 121
Mycobaterium avium Complex (MAC) disease	p. 123
Mycobaterium tuberculosis	p. 124
Penicilliosis	p. 126
Pneumocystis Pneumonia (PCP)	p. 127
Progressive Multifocal Leukoencephalopathy (PML)	p. 129
Salmonellosis	p. 130
Shigellosis	p. 131
Toxoplasma gondii Encephalitis	p. 132
Treponema pallidum (Syphilis)	p. 133
Varicella-Zoster Virus (VZV) Disease	p. 136
Complications of HIV Infection	p. 138
Hematologic Complications	p. 139
Thrombocytopenia	p. 139
Anemia	p. 139
Neutropenia	p. 140
Eosinophilia	p. 141
Oncologic Complications	p. 141
Kaposi's Sarcoma	p. 141
Non-Hodgkin's Lymphoma	p. 142
Primary CNS Lymphoma	p. 142
Cervical Cancer	p. 143
Anal Cancer	p. 143
Endocrine Complications	p. 143
Adrenal Insufficiency	p. 143
Hypogonadism	p. 144
Thyroid Disease	p. 144
Pancreatitis	p. 145
Hyperglycemia	p. 145
Hypoglycemia	p. 145
Ovarian Complications	p. 146
Bone Disease	p. 146
Gastrointestinal Complications	p. 147
Anorexia	p. 147
Nausea/Vomiting	p. 147
Diarrhea	p. 148
Oral or Esophageal Ulcers	p. 148
HIV Cholangiopathy	p. 149
Renal Complications	p. 149
HIV-Associated Nephropathy	p. 149
Medication-Related Renal Disease	p. 150
HCV-Associated Renal Disease	p. 151
Heroin Nephropathy	p. 151
Cardiac Complications	p. 151
HIV-Related Cardiomyopathy	p. 151
Pericarditis/Pericardial Effusion	p. 152
Tricuspid Valve Endocarditis	p. 152
Pulmonary Complications	p. 153
Pulmonary Hypertension	p. 153
Lymphocytic Interstitial Pneumonitis	p. 153
Emphysema	p. 153
Pulmonary Kaposi's Sarcoma	p. 154
HEENT Complications	p. 154
Aphthous Ulcers	p. 154
Oral Hairy Leukoplakia	p. 154
Salivary Gland Enlargement	p. 154
Lymphoepithelial Cysts	p. 154
Gingivitis/Periodontitis	p. 155
Musculoskeletal Complications	p. 155
HIV Arthropathy	p. 155
Reiter's Syndrome	p. 155
Pyomyositis	p. 155
HIV/NRTI-Related Myopathy	p. 156
Rhabdomyolysis	p. 156
Neurologic Complications	p. 156
Distal Sensory Neuropathy	p. 156
Other Forms of Neuropathy	p. 157
HIV-Associated/AIDS Dementia	p. 157
Psychiatric Complications	p. 158
Depression	p. 159
Mania	p. 159
Insomnia	p. 159
Dermatologic Complications	p. 159
Herpes Simplex Infection	p. 159
Varicella-Zoster Infection	p. 160
Molluscum Contagiosum	p. 160
Oral Hairy Leukoplakia	p. 160
Warts	p. 160
Staphylococcal Infections	p. 161
Bacillary Angiomatosis	p. 161
Fungal Infections	p. 162
Seborrheic Dermatitis	p. 162
Psoriasis	p. 162
Eosinophilic Folliculitis	p. 163
Xerosis/Ichthyosis	p. 163
HIV Infection and Pregnancy	p. 164
Overview	p. 165
Initial Evaluation	p. 165
Initiation of Antiretroviral Therapy in Pregnancy	p. 166
Goals of Therapy and Monitoring	p. 166
Management of HIV-Infected Pregnant Women Currently Receiving Antiretroviral Therapy	p. 168
Other Management and Monitoring Considerations	p. 168
Postpartum Management	p. 169
Post-Exposure Prophylaxis	p. 180
Occupational Post-Exposure Prophylaxis	p. 181
Nonoccupational Post-Exposure Prophylaxis	p. 187
Evaluation	p. 187
Use of Antiretroviral Therapy	p. 187
Follow-Up Testing	p. 188
Antiretroviral Drug Summaries	p. 190
	p. 236
IAS-USA Drug Resistance Mutations in HIV	p. 237
User Notes	p. 243
References to the User Notes	p. 247
	p. 250
Selected Key Internet Resources	p. 251
Reference	p. 252
Index	p. 253
Table of Contents provided by Ingram. All Rights Reserved.

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HIV Essentials 2011

144961339X

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