Apathy Clinical and Neuroscientific Perspectives from Neurology and Psychiatry

Krista Lanctot, Senior Scientist, Hurvitz Brain Sciences Program, Sunnybrook Research Institute; Professor of Psychiatry and Pharmacology, Vice Chair, Basic and Clinical Research, Department of Psychiatry, University of Toronto, ,André Aleman, Professor of Cognitive Neuropsychiatry, University
Medical Center Groningen and University of Groningen,

André Aleman received his masters degree in Psychology (Neuropsychology and Psychophysiology) at Utrecht University in 1997, where he also obtained his PhD (cum laude), in 2001. His current research interests concern the neural underpinnings of cognitive and affective dysfunctions in psychosis and
depression, in addition to changes in cognitive brain function during aging. In 2006 he received a European Young Investigator (EURYI) Award (1.2 M euro) from the European Science Foundation. In 2011 and 2012 he received large grants (1.5 M euro each) from the Netherlands Organization for Scientific
Research (VICI) and the European Research Council (ERC Starting/consolidator grant).


Dr. Krista Lanctôt is a Senior Scientist in the Hurvitz Brain Sciences Program at Sunnybrook Research Institute, the head of the Neuropsychopharmacology Research Group and the Executive Director of the Medical Outcomes and Research in Economics (MORE) Research Centre. She is a full professor in the
Departments of Psychiatry and Pharmacology & Toxicology at the University of Toronto. She is the Vice Chair of Basic and Clinical Research in the Department of Psychiatry at University of Toronto. Dr. Lanctôt is an active researcher in clinical pharmacology and has published over 300 manuscripts.
Her research focuses on optimizing the pharmacotherapy of cognition and neuropsychiatric symptoms associated with dementia and predementia states.

1. Definition of apathy and differential diagnosis, Philippe Robert and Valeria Manera
2. Measurement of apathy, Moyra Mortby, Bria Mele, Zahinoor Ismail, and David Miller
3. Apathy in Alzheimer's disease and MCI, Danielle Vieira, Celina Liu, and Krista Lanctôt
4. Apathy in movement disorders (Parkinson's disease, Huntington's), Gabriella Santangelo
5. Apathy in mild behavioural impairment, Zahinoor Ismail, Bria Mele, Zahra Goodarzi, Jayna Holroyd-Leduc, and Moyra Mortby
6. Apathy in cerebrovascular disorders, Sergio Starkstein and Bradleigh Hayhow
7. Apathy in schizophrenia, Ann Faerden and André Aleman
8. Apathy in traumatic brain injury, Konstantine Zakzanis, Kyrsten Grimes, and Eliyas Jeffay
9. Pathology of goal-directed behaviour, Richard Levy
10. Neural basis of apathy: Structural imaging studies, Ingrid Agartz
11. Brain reward systems and apathy, Stefan Kaiser and Florian Schlaugenhauf
12. Neural basis of apathy: Functional imaging studies, André Aleman
13. Treatment of apathy and pharmacology, Masud Husain and Lisa Nobis
14. Psychosocial approaches to the treatment of apathy, Marcel Riehle, Zuzana Kasanova, and Tania Lincoln
15. Brain stimulation, André Aleman, Jozarni Dlabac-De Lange and Prasad Padala