Signaling & Gene Expression in the Immune System Cold Spring Harbor Symposia on Quantitative Biology, Volume LXIV

• ISBN13: 9780879695699
• ISBN10: 0879695692
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-04-15
• Publisher: Cold Spring Harbor Laboratory Press
• More Book Details
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Summary

Provides a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke immunity. The debate ranges over biochemistry, physiology, molecular genetics, as well as classical cellular immunology. Input came from over 70 of the world's leading investigators.

Table of Contents

Symposium Participants	v
Foreword	xxi
Lymphocyte Development
Lymphoid Development from Stem Cells and the Common Lymphocyte Progenitors	1	(12)
K. Akashi
M. Kondo
S. Cheshier
J. Shizuru
K. Gandy
J. Domen
R. Mebius
D. Traver
I. L. Weissman
PU. 1, a Shared Transcriptional Regulator of Lymphoid and Myeloid Cell Fates	13	(8)
H. Singh
R. P. DeKoter
J. C. Walsh
Differentiation, Dedifferentiation, and Redifferentiation of B-lineage Lymphocytes: Roles of the Surrogate Light Chain and the	21	(6)
Pax5 Gene A. Rolink
S. Nutt
M. Busslinger
E. ten Boekel
T. Seidl
J. Andersson
F. Melchers
Notch and the CD4 Versus CD8 Lineage Decision	27	(6)
P. Valdez
E. Robey
Consequences of Notch-mediated Inhibition of the Transcription Factor E47	33	(6)
W. Pear
Z. Tang
S. DeRocco
D. Allman
R. Hardy
J. Pui
L. Xu
F. Karnell
J. Aster
T. Kadesch
Role of Helix-Loop-Helix Proteins in Lymphocyte Development	39	(6)
C. Murre
Controlling Lymphopoiesis with a Combinatorial E-protein Code	45	(6)
R. J. Barndt
Y. Zhuang
The Molecular Basis of B-cell Lineage Commitment	51	(10)
S. L. Nutt
A. G. Rolink
M. Busslinger
Role of B-lymphocyte-induced Maturation Protein-1 in Terminal Differentiation of B Cells and Other Cell Lineages	61	(10)
C. Angelin-Duclos
G. Cattoretti
D. H. Chang
K.-I. Lin
Y. Lin
J. Yu
K. Calame
The Lymphochip: A Specialized cDNA Microarray for the Genomic-scale Analysis of Gene Expression in Normal and Malignant Lymphocytes	71	(8)
A. Alizadeh
M. Eisen
R. E. Davis
C. Ma
H. Sabet
T. Tran
J. I. Powell
L. Yang
G. E. Marti
D. T. Moore
J. R. Hudson, Jr.
W. C. Chan
T. Greiner
D. Weisenburger
J. O. Armitage
I. Lossos
R. Levy
D. Botstein
P. O. Brown
L. M. Staudt
Transcription Factors and the Control of Lymphocyte Development
Ikaros Chromatin Remodeling Complexes in the Control of the Differentiation of the Hemo-lymphoid System	79	(8)
J. Koipally
J. Kim
B. Jones
A. Jackson
N. Avitahl
S. Winandy
M. Trevisan
A. Nichogiannopoulou
C. Kelley
K. Georgopoulos
Mechanisms of Transcriptional Regulation in Lymphocyte Progenitors: Insight from an Analysis of the Terminal Transferase Promoter	87	(12)
P. Ernst
K. Hahm
B. S. Cobb
K. E. Brown
L. A. Trinh
A. S. McCarty
M. Merkenschlager
C. A. Klug
A. G. Fisher
S. T. Smale
Mechanisms of μ Enhancer Regulation in B Lymphocytes	99	(10)
B. S. Nikolajczyk
W. Dang
R. Sen
Differential Regulation of Immunoglobulin Gene Transcription via Nuclear Matrix-associated Regions	109	(10)
C. Webb
R.-T. Zong
D. Lin
Z. Wang
M. Kaplan
Y. Paulin
E. Smith
L. Probst
J. Bryant
A. Goldstein
R. Scheuermann
P. Tucker
B-cell-specific Coactivator OCA-B: Biochemical Aspects, Role in B-Cell Development and Beyond	119	(14)
Y. Luo
R. G. Roeder
Control of Lymphocyte Differentiation by the LEF-1/TCF Family of Transcription Factors	133	(8)
T. Reya
R. Okamura
R. Grosschedl
Activation and Repression of Wingless/Wnt Target Genes by the TCF/LEF-1 Family of Transcription Factors	141	(8)
H. C. Korswagen
H. C. Clevers
The INF-β Enhancer: A Paradigm for Understanding Activation and Repression of Inducible Gene Expression	149	(12)
N. Munshi
J. Yie
M. Merika
K. Senger
S. Lomvardas
T. Agalioti
D. Thanos
Recombination and Allelic Exclusion
V(D)J Recombination: Links to Transposition and Double-strand Break Repair	161	(8)
M. Gellert
J. E. Hesse
K. Hiom
M. Melek
M. Modesti
T. T. Paull
D. A. Ramsden
D. C. van Gent
Nonhomologous End-joining Proteins Are Required for V(D)J Recombination, Normal Growth, and Neurogenesis	169	(14)
J. M. Sekiguchi
Y. Gao
Y. Gu
K. Frank
Y. Sun
J. Chaudhuri
C. Zhu
H.-L. Cheng
J. Manis
D. Ferguson
L. Davidson
M. E. Greenberg
F. W. Alt
Regulation of Chromatin Accessibility for V(D)J Recombination	183	(8)
C. Hernandez-Munain
M. Taylor McMurry
M. S. Krangel
What Prevents Intermolecular V(D)J Recombination?	191	(6)
L. E. Huye
J.-O. Han
D. B. Roth
Demethylation and the Establishment of κ Allelic Exclusion	197	(10)
R. Mostoslavsky
A. Kirillov
Y.-H. Ji
M. Goldmit
M. Holzmann
T. Wirth
H. Cedar
Y. Bergman
RAG Expression in B Cells in Secondary Lymphoid Tissues	207	(4)
W. Yu
H. Nagaoka
Z. Misulovin
E. Meffre
H. Suh
M. Jankovic
N. Yannoutsos
R. Casellas
E. Besmer
F. Papavasiliou
X. Qin
M. C. Nussenzweig
Antibody Diversification and Selection in the Mature B-Cell Compartment	211	(6)
M. S. Neuberger
A. Lanoue
M. R. Ehrenstein
F. D. Batista
J. E. Sale
G. T. Williams
Molecular Mechanism of Immunoglobulin Class Switch Recombination	217	(10)
K. Kinoshita
C.-G. Lee
J. Tashiro
M. Muramatsu
X.-C. Chen
K. Yoshikawa
T. Honjo
Molecular Aspects of Somatic Hypermutation of Immunoglobulin Genes	227	(8)
U. Storb
A. Peters
N. Kim
H. M. Shen
G. Bozek
N. Michael
J. Hackett
Jr.
E. Klotz
J. D. Reynolds
L. A. Loeb
T. E. Martin
T-cell Activation and Receptor Signaling
Structural, Biochemical, and Biophysical Studies of HLA-A2/Altered Peptide Ligands Binding to Viral-peptide-specific Human T-cell Receptors	235	(8)
B. M. Baker
Y.-H. Ding
D. N. Garboczi
W. E. Biddison
D. C. Wiley
Visualizing T-cell Recognition	243	(10)
M. M. Davis
C. Wulfing
M. F. Krummel
P. A. Savage
J. Xu
C. Sumen
M. L. Dustin
Y.-H. Chien
Three Signals and a Master Switch in the Regulation of T-cell Immunity	253	(6)
A. Lanzavecchia
Studies on the Adapter Molecule LAT	259	(6)
L. E. Samelson
S. C. Bunnell
R. P. Trible
T. Yamazaki
W. Zhang
The Adapter Proteins LAT and SLP-76 Are Required for T-cell Activation	265	(10)
T. S. Finco
D. Yablonski
J. Lin
A. Weiss
Signaling in Primary Thymocytes after Presentation of Altered Peptide Ligands by Antigen-presenting Cells or MHC-peptide Tetramers	275	(8)
L. A. Smyth
L. Reynolds
R. Tyrrell
O. Williams
T. Norton
T. Schumacher
V. Tybulewicz
S. C. Ley
D. Kioussis
The Impact of Pre-T-cell Receptor Signals on Gene Expression in Developing T Cells	283	(8)
H. von Boehmer
I. Aifantis
O. Azogui
C. Saint-Ruf
F. Grassi
The PTK-STAT Signaling Pathway Has Essential Roles in T-cell Activation in Response to Antigen Stimulation	291	(12)
T. Welte
D. Leitenberg
B. N. Dittel
B. K. al-Ramadi
W. R. Hansen
B. Xie
C. A. Janeway
Jr.
A. L. M. Bothwell
K. Bottomly
X.-Y. Fu
CTLA-4-The Costimulatory Molecule That Doesn't: Regulation of T-cell Responses by Inhibition	303	(10)
C. A. Chambers
J. P. Allison
B-cell Activation and Receptor Signaling
Mechanisms of Self-tolerance and Autoimmunity: From Whole-animal Phenotypes to Molecular Pathways	313	(10)
C. C. Goodnow
R. Glynne
D. Mack
B. Weintraub
J. Rathmell
J. I. Healy
S. Chaudhry
L. Miosge
A. Loy
L. Wilson
The Maintenance and the Activation Signal of the B-cell Antigen Receptor	323	(6)
M. Reth
J. Wienands
Inhibitory Receptors and Their Modes of Action	329	(6)
D. C. Fong
J. C. Cambier
Cell Death and Survival in the Immune System
Genetic Analysis of Apoptotic and Survival Signals	335	(8)
T. W. Mak
W.-C. Yeh
Death and Survival Signals Determine Active/Inactive Conformations of Pro-apoptotic BAX, BAD, and BID Molecules	343	(8)
S. J. Korsmeyer
A. Gross
H. Harada
J. Zha
K. Wang
X.-M. Yin
M. Wei
S. Zinkel
Control of Apoptosis in Hematopoietic Cells by the Bcl-2 Family of Proteins	351	(8)
J. M. Adams
D. C. S. Huang
H. Puthalakath
P. Bouillet
G. Vairo
K. Moriishi
G. Hausmann
L. O'Reilly
K. Newton
S. Ogilvy
M. L. Bath
C. G. Print
A. W. Harris
A. Strasser
S. Cory
RIPs: An Emerging Family of Kinases Involved in Pro-inflammatory and Apoptotic Signaling	359	(4)
V. M. Dixit
Receptor-mediated Apoptosis in T Lymphocytes	363	(10)
J. Zhang
A. DeYoung
H. G. Kasler
N. H. Kabra
A. A. Kuang
G. Diehl
S. J. Sohn
C. Bishop
A. Winoto
Role of the Nuclear Hormone Receptor RORγ in Transcriptional Regulation, Thymocyte Survival, and Lymphoid Organogenesis	373	(10)
D. R. Littman
Z. Sun
D. Unutmaz
M. J. Sunshine
H. T. Petrie
Y.-R. Zou
What Keeps a Resting T Cell Alive?	383	(6)
C. B. Thompson
J. C. Rathmell
K. A. Frauwirth
T. Lindsten
C. M. Rudin
J. T. Opferman
P. G. Ashton-Rickardt
M. H. Harris
N. S. Chandel
P. T. Schumacker
M. G. Vander Heiden
Cytokine Signaling and Responses
Differential Roles of Cytokine Signaling during T-cell Development	389	(8)
R. Moriggl
J.-C. Marine
D. J. Topham
S. Teglund
V. Sexl
C. McKay
R. Piekorz
D. Wang
E. Parganas
A. Yoshimura
J. N. Ihle
Negative Regulation of Cytokine Signaling by the SOCS Proteins	397	(8)
N. A. Nicola
S. E. Nicholson
D. Metcalf
J.-G. Zhang
M. Baca
A. Farley
T. A. Willson
R. Starr
W. Alexander
D. J. Hilton
IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCS Proteins to the Receptor Complex	405	(12)
J. Losman
X. P. Chen
H. Jiang
P.-Y. Pan
M. Kashiwada
C. Giallourakis
S. Cowan
K. Foltenyi
P. Rothman
Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus	417	(8)
W. J. Leonard
K. Imada
H. Nakajima
A. Puel
E. Soldaini
S. John
Potential Roles of Stat1 and Stat3 in Cellular Transformation	425	(4)
J. F. Bromberg
J. E. Darnell, Jr.
Innate Immune Induction of the Adaptive Immune Response	429	(8)
R. Medzhitov
C. A. Janeway, Jr.
Attenuation of Tumor Necrosis Factor α Gene Transcription in Macrophages by an Autocrine Factor	437	(8)
M. Baer
S. Nedospasov
P. F. Johnson
Mechanism of Chromatin Recognition and Transcriptional Regulation by LEF-1 and the Wnt/Wg-responsive LEF-1:β-Catenin Complex	445	(8)
A. Tutter
G. S. McAlpine
K. A. Jones
HIV and SIV Nef Modulate Signal Transduction and Protein Sorting in T Cells	453	(12)
J. Skowronski
M. E. Greenberg
M. Lock
R. Mariani
S. Salghetti
T. Swigut
A. J. Iafrate
Transcription Factor IRF-1 and Its Family Members in the Regulation of Host Defense	465	(8)
T. Taniguchi
N. Tanaka
K. Ogasawara
S. Taki
M. Sato
A. Takaoka
NF-κB/NF-AT/TRAF
NF-κB Activation by Tumor Necrosis Factor and Interleukin-1	473	(12)
Z. Cao
M. Tanaka
C. Regnier
M. Rothe
A. Yamit-hezi
J. D. Woronicz
M. E. Fuentes
M. H. Durnin
S. A. Dalrymple
D. V. Goeddel
Role of NF-κB in T-lymphocyte Development	485	(6)
R. E. Voll
S. Ghosh
The IκB Kinase: A Master Regulator of NF-κB, Innate Immunity, and Epidermal Differentiation	491	(14)
M. Delhase
M. Karin
Signaling through Calcium, Calcineurin, and NF-AT in Lymphocyte Activation and Development	505	(12)
K. Stankunas
I. A. Graef
J. R. Neilson
S.-H. Park
G. R. Crabtree
NF-AT5: The NF-AT Family of Transcription Factors Expands in a New Direction	517	(10)
C. Lopez-Rodriguez
J. Aramburu
A. S. Rakeman
N. G. Copeland
D. J. Gilbert
S. Thomas
C. Disteche
N. A. Jenkins
A. Rao
Signal Integration by Transcription-factor Assemblies: Interactions of NFAT1 and AP-1 on the IL-2 Promoter	527	(6)
L. Chen
A. Rao
S. C. Harrison
Structure and Mechanism in NF-κB/IκB Signaling	533	(8)
T. Huxford
S. Malek
G. Ghosh
Structural Studies of Human TRAF2	541	(10)
H. Wu
Y. C. Park
H. Ye
L. Tong
Structural and Biochemical Analysis of Signal Transduction by the TRAF Family of Adapter Proteins	551	(12)
S. M. McWhirter
S. S. Pullen
B. G. Werneburg
M. E. Labadia
R. H. Ingraham
J. J. Crute
M. R. Kehry
T. Alber
T-cell Differentiation
Molecular Basis of T-cell Differentiation	563	(10)
R. A. Flavell
B. Li
C. Dong
H.-T. Lu
D. D. Yang
H. Enslen
C. Tournier
A. Whitmarsh
M. Wysk
D. Conze
M. Rincon
R. J. Davis
Tissue-specific Regulation of Cytokine Gene Expression	573	(12)
I.-C. Ho
J. I. Kim
S. J. Szabo
L. H. Glimcher
Bi-stable Transcriptional Circuitry and GATA-3 Auto-activation in Th2 Commitment	585	(4)
K. M. Murphy
W. Ouyang
S. Ranganath
T. L. Murphy
Multiple Levels of Regulation of Th2 Cytokine Gene Expression	589	(10)
N. Arai
H. J. Lee
I. Ferber
H. Kurata
A. O'Garra
Bias in the Expression of IL-4 Alleles: The Use of T Cells from a GFP Knock-in Mouse	599	(4)
C. Pannetier
J. Hu-Li
W. E. Paul
Summary: Signals and Beyond	603	(8)
R. A. Flavell
Author Index	611	(2)
Subject Index	613