Targeted Cancer Therapy

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  • Edition: 1st
  • Format: Paperback
  • Copyright: 2009-12-30
  • Publisher: Jones & Bartlett Learning
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Targeted Cancer Therapy: A Handbook for Nurses is an essential guide for nurses interested in the latest discoveries in oncology. Covering the most recent treatment option of transforming cancer into a chronic illness, Targeted Cancer Therapy provides nurses with the information they need to understand this and future developments in the field. This comprehensive but easy-to-understand text takes nurses through foundational concepts in cell and normal biology that are crucial to understanding cancer and targeted therapy. Featuring relevant analogies and easy-to-follow discussions on malignant transformation, metastases, cellular pathways, and toxicities, this one-of-a-kind text enables nurses to quickly get up to speed on key topics and develop care plans for oncology patients. Accessible, comprehensive, informative, Targeted Cancer Therapy is a must-read for every oncology nurse. Key features include: Easy-to-understand overview of biology Key topics in malignant transformation, invasion, and metastases Discussion on the microenvironment, angiogenesis, cellular pathways targeted during treatment, and potential drug side effects Care plan for patients receiving treatment Motivating patients dealing with cancer as a chronic illness

Table of Contents

Introductionp. v
Cancer Biology, Signaling Pathways, and Malignant Transformationp. 1
Hallmarks of Cancerp. 1
Application of the Hallmarks of Cancerp. 2
Invasion and Metastasisp. 18
Epigeneticsp. 30
Summaryp. 34
Referencesp. 34
Targeted Cancer Therapy: External and Internal Signaling Pathway Targetsp. 39
Monoclonal Antibodiesp. 42
Membrane-Bound Receptor Kinases (e.g., EGFR, HER2, HGF/c-Met, IGFR pathways)p. 73
Hepatocyte Growth Factor (HGF/c-Met) Receptor Pathway Targetsp. 125
Insulin-like Growth Factor Receptor Pathway Targetsp. 127
Intracellular Signaling Kinases (e.g., src, P13k/Akt/mTOR; MAPK; sonic hedgehog pathways)p. 128
Protein Kinase Signaling Pathwaysp. 129
Protein Kinase Inhibitorsp. 136
Protein Dynamics: Heat Shock Proteins and Ubiquitin-Proteasome Inhibitorsp. 150
Epigenetic Abnormalities (DNA Methyltransferase and Histone Deacetylase)p. 160
Tumor Vasculature and Microenvironmentp. 175
Referencesp. 175
Tumor Vasculaturep. 185
Targeting Angiogenesisp. 185
Antiangiogenic Drug Therapyp. 194
Hypoxia-Inducible Factor, mTOR, and Angiogenesisp. 198
Nursing Considerations and Drug Informationp. 203
Referencesp. 250
Targeting the Microenvironment: Bone Metastasis, Apoptosis, DNA Repair, and Mitosisp. 255
Bone Metastasisp. 255
Pharmacologic Managementp. 262
Targeting Apoptosisp. 271
DNA Repair Gene Mutations: Opportunities from Synthetic Lethalityp. 277
Mitotic Kinase Inhibitorsp. 280
Summaryp. 284
Referencesp. 284
Challenges in Caring for Patients Receiving Targeted Therapyp. 289
Drag Interactions: Focus on the P450 Microenzyme Systemp. 289
Encouraging Patient Adherence and Persistencep. 302
Referencesp. 310
Glossaryp. 313
Indexp. 329
Table of Contents provided by Ingram. All Rights Reserved.

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