Telomerases Chemistry, Biology, and Clinical Applications

by Lue, Neal F.; Autexier, Chantal

• ISBN13: 9780470592045
• ISBN10: 0470592044
• eBook ISBN(s): 9781118267516
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-06-26
• Publisher: Wiley
• More Book Details
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Summary

This book is& a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research.& Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase.& Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

Author Biography

Neal F. Lue, MD, PhD, is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems. Chantal Autexier, PhD, is Professor in the Department of Anatomy and Cell Biology and the Department of Medicine at McGill University. She received her BSc from Concordia University and her PhD from, McGill University. Her laboratory studies the mechanisms that regulate telomerase and telomere functions in mammalian cells, and evaluates the principles of anticancer strategies that target these mechanisms.

Table of Contents

Preface	p. vii
Contributors	p. ix
The Telomerase Complex: An Overview	p. 1
Telomerase RNA: Structure, Function, and Molecular Mechanisms	p. 23
TERT Structure, Function, and Molecular Mechanisms	p. 53
Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions	p. 79
Transcriptional Regulation of Human Telomerase	p. 105
Telomerase Regulation and Telomere-Length Homeostasis	p. 135
Telomere Structure in Telomerase Regulation	p. 157
Off-Telomere Functions of Telomerase	p. 201
Murine Models of Dysfunctional Telomeres and Telomerase	p. 213
Cellular Senescence, Telomerase, and Cancer in Human Cells	p. 243
Telomerase, Retrotransposons, and Evolution	p. 265
Index	p. 301
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