Thrombolysis and Acute Stoke Preparing for the Next Decade

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  • Format: Paperback
  • Copyright: 2012-10-23
  • Publisher: Wiley-Blackwell
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Leading and emerging investigators from within and outside the immediate area of cerebrovascular disease have come together to explore the state-of-the-art and future directions of research and clinical practice leading to enhanced medical care in the acute treatment of ischemic stroke. The agenda highlights various facets of acute intervention and a number of unaddressed issues related to the medical setting of stroke that impact clinical outcomes and provide opportunities for improving treatment. The main goals are the generation of data-driven, multidisciplinary ideas, to explore ischemic stroke as a systemic disease related to other disease entities (hypertension, diabetes, and disorders of aging), and to better address the evolution of ischemic brain injury. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Table of Contents

vii     Introduction to Thrombolysis and Acute Stroke Treatment: Preparing for the Next Decade
        Gregory J. del Zoppo and Andrei V. Alexandrov

1      Advanced multimodal CT/MRI approaches to hyperacute  stroke diagnosis, treatment and  monitoring
        David S. Liebeskind and Andrei V. Alexandrov

 8      The future of stroke thrombolysis
         Antoine M. Hakim

14     Population shifts and the future of stroke: forecasts of the future burden of stroke
        George Howard and David C. Goff

21     Pathobiology of injury after stroke: the neurovascular unit and beyond
         Ulrich Dirnagl

26     The ischemic penumbra: how does tissue injury evolve?
        Wolf-Dieter Heiss

35     Current treatment of basilar artery occlusion
         Perttu J. Lindsberg, Tiina Sairanen, Daniel Strbian, and Markku Kaste

45     Improving public education about stroke
        Mark J. Alberts

51     Impact of regional pre-hospital emergency medical services in treatment of patients with acute ischemic stroke              
        Cemal B. Sozener and William G. Barsan


57     Techniques for improving efficiency in the emergency department for patients with acute ischemic stroke
        Edward C. Jauch, Christine Holmstedt, and Justin Nolte

63     Imaging-based selection in acute ischemic stroke trials- a quest for imaging sweet spots
        Andrew M. Demchuk, Bijoy Menon, and Mayank Goyal

72     Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial
         Andrew M. Southerland and Karen C. Johnson 

79     Treatment of acute ischemic stroke: systemic or local?
         Rudiger von Kummer and Johannes Gerber

85     How baseline severity affects efficacy and safety outcomes in acute ischemic stroke intervention trials
        Philip B. Gorelick

95     Does inhibiting Sur1 complement rt-PA in cerebral ischemia?
        J. Marc Simard, Zhihua Geng, Frank L. Silver, Kevin N. Sheth, W. Taylor Kimberly, Barney J.  Stern, Mario Colucci, and Volodymyr Gerzanich

108   Safety and efficacy of 0.6 mg/kg rt-PA: optimum rt-PA dose revisited
        Etsuro Mori

113   Ancillary approaches to plasminogen activators
        Reza Bavarsad Shahripour and Andrei V. Alexandrov

120   Selection of possible responders to thrombolytic therapy in acute ischemic stroke
        Christian Hametner, Peter Arthur Ringleb, Werner Hacke, and Lars Kellert

127   Aging and the neurovascular unit
        Gregory J. del Zoppo

134   Intra-arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate
        Ziad M.K. El-Zammar, Julius Gene S. Latorre, Dongliang Wang, Shyama Satyan, Elwaleed Elnour, Adham Kamel, Ashok Devasenapathy, and Yahia M. Lodi


141   Timing of thrombolysis for acute ischemic stroke: “timing is everything” or “everyone is different”
        James Grotta

145   Pre- and in-hospital intersection of stroke care
        Atte Meretoja and Markku Kaste

152   A strategic plan to accelerate development of acute stroke treatments
        John R. Marler

157   Corrigendum for Ann. N.Y. Acad. Sci. 2010. 1195. 1-27




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