Vascular Cognitive Impairment in Clinical Practice

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-02-23
  • Publisher: Cambridge University Press
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Vascular cognitive impairment is the second most common cause of dementia after Alzheimer's disease and is expected to grow in prevalence with the aging global population. The purpose of this authoritative book is to give a broad clinical perspective on vascular cognitive impairment and thus create a foundation for the implementation of good dementia care. The book focuses on pathophysiology, diagnosis, treatment and prevention. It demonstrates the underlying causes of the disorder, such as the manner in which vascular risk-factors influence the onset of vascular cognitive impairment. The concept of mixed forms of vascular dementia, Alzheimer's dementia and other vascular diseases is discussed as well as the influence of vascular changes with regard to the onset of Alzheimer's disease. The detailed section on pathophysiology will enhance clinicians' understanding of this complex disorder. Finally there is a section on pharmacological and neuropsychological treatment of cognitive and psychiatric symptoms.

Author Biography

Lars-Olof Wahlund is a Professor at the Department of Neurobiology, Caring Sciences and Society at the Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. Timo Erkinjuntti is Professor of Neurology at the Department of Neurology, University of Helsinki, Finland. Serge Gauthier is a Professor and Director at the Alzheimer's Disease and Related Disorders Research Unit, McGill Centre for Studies on Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada.

Table of Contents

List of Contributorsp. vii
Prefacep. xi
Diagnosisp. 1
Diagnosing vascular cognitive impairment and dementia: concepts and controversiesp. 3
Vascular cognitive impairment: prodrome to VaD?p. 11
Clinical evaluation: a systematic but user-friendly approachp. 32
Cognitive functioning in vascular dementia before and after diagnosisp. 46
Structural neuroimaging: CT and MRIp. 58
Functional imaging in vascular dementia: clinical practicep. 70
Biomarkers in vascular dementiap. 77
Pathophysiologyp. 93
Physiopathology of large-vessel vascular dementiap. 95
Small-vessel diseases of the brainp. 118
White matter changesp. 131
Hereditary forms of cerebrovascular amyloidosisp. 139
Role of vascular risk factors in dementiap. 155
Cardiovascular disease, cognitive decline, and dementiap. 166
Vascular factors in Alzheimer's disease: from diagnostic dichotomy to integrative etiologyp. 178
Treatmentp. 193
Treatment of cognitive changesp. 195
Treatment of functional declinep. 200
Treatment of behavioral symptoms in vascular dementiap. 206
Control of vascular risk factorsp. 220
Indexp. 235
Table of Contents provided by Ingram. All Rights Reserved.

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