IN VIVO MODELS OF INFLAMMATION

by Morgan, D.W.

• ISBN13: 9783764358761
• ISBN10: 3764358769
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-05-01
• Publisher: SPRINGER VERLAG INC

Summary

Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. The aim of this second edition is to act as a complement to the first by describing and updating the standard models that are most utilized for specific disease areas. In addition, this 2nd edition includes new models exploring emerging areas of inflammation research.It provides detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. New approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has also been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. The book provides the scientist with an up-to-date reference manual for selecting the best animal model for their specific question. Chapters describing current regulations in the United States, United Kingdom, and Japan are also included.

Table of Contents

List of contributors
Preface
Comparison of adjuvant and streptococcal cell wall-induced arthritis in the rat	p. 1
Murine collagen-induced arthritis	p. 51
Joint and cartilage degradation	p. 77
Angiogenesis	p. 93
Asthma	p. 111
Allergen-induced airway inflammation and airway hyperreactivity in mice	p. 137
Chronic obstructive pulmonary disease	p. 159
Skin inflammation	p. 179
Animal models of inflammatory bowel disease	p. 205
T cell-mediated diseases of immunity	p. 237
Transplantation	p. 265
Transgenics	p. 291
Gene transfer technology	p. 307
Guidelines and regulations in animal experimentation	p. 333
Index	p. 337
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