Wnt Signaling in Development and Disease Molecular Mechanisms and Biological Functions

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  • Format: Hardcover
  • Copyright: 2014-05-05
  • Publisher: Wiley-Blackwell
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Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress.

Table of Contents

  1. Wnt signal production, secretion and diffusion
    Madelon M. Maurice and Hendrik C. Korswagen

  2. Wnt signaling at the membrane
    Gary Davidsonand Christof  Niehrs

  3. Wnt signal transduction in the cytoplasm: an introduction to the destruction complex
    Tony W. Chen, Heather A. Wallace, Yashi Ahmed and Ethan Lee

  4. An overview of gene regulation by Wnt/b-catenin signaling
    Chen U. Zhang and Ken M. Cadigan

  5. Finding a Needle in a Genomic Haystack: Genome-wide Approaches to Identify Wnt/TCF Transcriptional Targets
    Chandan Bhambhani and Ken M. Cadigan

  6. Introduction to b-catenin independent Wnt signaling pathways
    Susanne Kühl and Michael Kühl

  7. Molecular mechanisms of Wnt pathway specificity
    Alexandra Schambony, Guido J.R. Zaman, Folkert Verkaar

  8. Modulation of Wnt signaling by endocytosis of receptor complexes
    Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, Akira Sato

  9. New insights from proteomic analysis of WNT signaling
    Matthew P. Walker, Dennis Goldfarband Michael B. Major

  10. New insights about Wnt pathway mechanisms from global siRNA screens
    Tenzin Gocha and Ramanuj DasGupta

  11. Mathematical models of Wnt signaling pathways
    Michael Kühl, Barbara Kracher, Alexander Groß, and Hans Kestler

  12. The Wnt’s tale:  On the evolution of a signaling pathway
    Jenifer C. Croce and Thomas W. Holstein

  13. Secreted Wnt inhibitors or modulators
    Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve and Herbert Steinbeisser

  14. Frizzleds as G protein-coupled receptors
    Gunnar Schulte

  15. Dishevelled, at the crossroads of pathways
    Vítězslav Bryja and Ondřej Bernatík

  16. β-catenin: a key player in both cell adhesion and wnt signaling
    Jonathan Pettitt

  17. Evolutionary Diversification of vertebrate TCF/LEF structure, function, and regulation
    Stefan Hoppler and Marian L. Waterman

  18. Insights from Structural Analysis of Protein-protein Interactions by Wnt Pathway Components and Functional Multi-protein Complex Formation
    Zhihong Cheng and Wenqing Xu

  19. Wnt signaling in early vertebrate development: from fertilization to gastrulation
    Eliza Zylkiewicz, Sergei Y. Sokol and Stefan Hoppler

  20. Wnt/ß-catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development
    Kathryn C. Davidson

  21. Wnt Signaling Specifying Neural Lineages
    Richard Dorsky

  22. Wnt signaling in Heart Organogenesis
    Stefan Hoppler, Silvia Mazzotta and Michael Kühl

  23. Wnt signaling in kidney organogenesis
    Kimmo Halt and Seppo Vainio

  24. Wnt signaling regulation of tissue architecture (EMT and MET) and morphogenesis: consequences for Colorectal and Liver Cancer
    T Fifis, BM Tran BM, RHM Schwab, TM Johanson, N Warner, N Barker, E Vincan

  25. Wnt signaling in adult stem cells: tissue homeostasis and regeneration
    Frank J.T. Staal and Riccardo Fodde

  26. Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury
    Günes Özhan and Gilbert Weidinger

  27. Wnt Signaling and colorectal cancer
    Kevin Myant and Owen J Sansom

  28. Wnt signaling in melanoma
    Jamie N. Anastas and Andy J. Chien

  29. Wnt Signaling in Mood & Psychotic Disorders
    Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya

  30. Neuropsychiatric Disease-associated Genetic Variation in the Wnt Pathway
    Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya

  31. Wnt Signaling in Dementia
    Stephen J. Haggarty

  32. Therapeutic targeting of the Wnt signaling network
    Felicity Rudge and Trevor Dale

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