Acquired Long Qt Syndrome

by Camm, A. John; Malik, Marek; Yap, Yee Guan

• ISBN13: 9781405118385
• ISBN10: 1405118385
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-09-03
• Publisher: Wiley-Blackwell

Summary

In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death.In this volume, arrhythmia specialists from St. George's Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.

Author Biography

A. John Camm, MD, FRCP, FESC, FACC
Professor of Clinical Cardiology and Head, Department of Cardiological Sciences, St. George’s Hospital Medical School, London

Marek Malik, PhD, MD, DSc, FACC, FECS
Professor of Cardiac Electrophysiology, Department of Cardiological Sciences, St. George’s Hospital Medical School, London

Yee Guan Yap, BMedSci, MBBS, MRCP
British Heart Foundation Research Fellow in Cardiology, Department of Cardiological Sciences, St. George’s Hospital Medical School, London

Table of Contents

Preface	vi
Introduction	1	(7)
Mechanisms of acquired QT prolongation and torsades de pointes	8	(16)
Measurement of the QT interval and repolarization assessment	24	(36)
Introduction to drug-induced long QT syndrome	60	(9)
Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs	69	(18)
Risk of QT prolongation and torsades de pointes with antihistamines	87	(15)
Risk of QT prolongation and torsades de pointes with psychotropic drugs	102	(19)
Risk of QT prolongation and torsades de pointes with antimicrobial and antimalarial drugs	121	(19)
Risk of QT prolongation and torsades de pointes with prokinetics and miscellaneous other drugs	140	(23)
Acquired long QT syndrome secondary to cardiac conditions	163	(8)
Acquired long QT syndrome secondary to noncardiac conditions	171	(11)
Perspective on drug-induced repolarization changes	182	(9)
Index	191