Adrenocortical Carcinoma

by Hammer, Gary D.; Else, Tobias

• ISBN13: 9780387772356
• ISBN10: 0387772359
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-11-24
• Publisher: Springer Verlag

Summary

We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters with cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practicioner and community of adrenal cancer scientists. We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.

Table of Contents

History of Adrenocortical Carcinoma Research and Clinical Care
The History of Adrenocortical Carcinoma Treatment - A Medical Perspective	p. 3
The History of Adrenocortical Carcinoma Treatment - A Surgical Perspective	p. 9
Epidemiology, Presentation and Diagnosis
Epidemiology of Adrenocortical Carcinoma	p. 23
Clinical Presentation and Initial Diagnosis	p. 31
Diagnostic Approach to Incidentaloma	p. 49
Imaging
Computed Tomography/Magnetic Resonance Imaging of Adrenocortical Carcinoma	p. 67
Functional Imaging of Adrenocortical Carcinoma	p. 85
Pathology
Classical Histopathology and Immunohistochemistry	p. 107
Cellular and Molecular Pathology of Adrenocortical Carcinoma	p. 127
Genetic and Molecular Aspects
Overview of Genetic Syndromes Associated with Adrenocortical Cancer	p. 153
Li-Fraumeni Syndrome	p. 173
TP53 Molecular Genetics	p. 193
Telomeres and Telomerase in Adrenocortical Carcinoma	p. 207
Beckwith-Wiedemann Syndrome	p. 227
The Insulin-Like Growth Factor System in Adrenocortical Growth Control and Carcinogenesis	p. 235
WNT/ß-Catenin Signaling in Adrenocortical Carcinoma	p. 263
Models of Adrenocortical Cancer
Adrenocortical Stem and Progenitor Cells: Implications for Cancer	p. 285
Adrenocortical Cell Lines	p. 305
Mouse Models of Adrenal Tumorigenesis	p. 325
Therapies
Overview of Treatment Options for Adrenocortical Carcinoma	p. 343
Chemotherapy	p. 351
Mitotane	p. 369
Pharmacotherapy for Hormone Excess in Adrenocortical Carcinoma	p. 383
Surgery for Adrenocortical Carcinoma	p. 403
Radiation Therapy for Adrenocortical Carcinoma	p. 427
Follow-Up and Monitoring of Adrenocortical Carcinoma	p. 443
Unique Cohorts and Future Perspectives
Aldosterone-Producing Adrenocortical Carcinoma	p. 457
Adrenocortical Cancer in Children	p. 467
Genome-Wide Studies in Adrenocortical Neoplasia	p. 483
New Strategies for the Treatment of Adrenocortical Carcinoma	p. 493
Adrenal Cancer Networks and Registries
The Dutch Adrenal Network	p. 517
The ENS@T Initiative	p. 521
Index	p. 533
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