Adult Acute Lymphocytic Leukemia

by Advani, Anjali S., M.D.; Lazarus, Hillard M., M.D.

• ISBN13: 9781607617068
• ISBN10: 1607617064
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-11-30
• Publisher: Humana Pr Inc

Summary

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. Topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the treatment of your adults with ALL, the role of minimal residual disease in making treatment decisions, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. The full spectrum of ALL subtypes and their treatments are covered.Focusing especially upon the adult ALL patient, this book is the first of its kind. It provides a complete overview of diagnosis, molecular pathogenesis, and treatment for this important patient population.

Table of Contents

A Perspective on the Treatment of Acute Lymphoblastic Leukemia in Adults	p. 1
Acute Lymphocytic Leukemia - Clinical Features and Making the Diagnosis	p. 9
The Biology of Adult Acute Lymphoblastic Leukemia	p. 25
Minimal Residual Disease in Acute Lymphoblastic Leukemia	p. 45
Cytogenetics	p. 61
Acute Lymphoblastic Leukemia: Epidemiology	p. 77
Prognostic Factors in Adult Acute Lymphoblastic Leukemia (ALL)	p. 89
The Generalized Care of the Patient with Acute Lymphoblastic Leukemia	p. 97
Treatment of Acute Lymphoblastic Leukemia in Middle-Age and Older Adults	p. 115
Pharmacology of Acute Lymphoblastic Leukemia Therapy	p. 127
Assessment of Response to Treatment	p. 145
T-Cell Acute Lymphoblastic Leukemia	p. 157
Burkitt Lymphoma and Leukemia	p. 175
Treatment of Acute Lymphoblastic Leukemia in Young Adults	p. 211
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia	p. 233
Molecular Therapies	p. 257
Treatment of Relapsed Acute Lymphoblastic Leukemia	p. 277
Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukaemia in Adults	p. 297
Hematopoietic Stem Cell Transplantation in Philadelphia-Positive Acute Lymphoblastic Leukemia	p. 305
Special Challenges: Genetic Polymorphisms and Therapy	p. 315
Late Consequences of Therapy of Acute Lymphoblastic Leukemia	p. 331
Immunotherapy for Acute Lymphocytic Leukemia	p. 351
Unique Subtypes in Acute Lymphoblastic Leukemia	p. 365
Index	p. 383
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