Advances in Carbohydrate Chemistry and Biochemistry

by Horton

• ISBN13: 9780123808561
• ISBN10: 0123808561
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-03-03
• Publisher: Elsevier Science

Summary

Since its inception in 1945, this serial has provided critical articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. Contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field

Table of Contents

Contributors	p. ix
Preface	p. xi
Roger W. Jeanloz 1917-2007
Bengt Lindberg 1919-2008
Zeolites and Other Silicon-Based Promoters in Carbohydrate Chemistry
Introduction	p. 30
Zeolites, Clays, and Silica Gel as Heterogeneous Catalysts and Their Use in Organic Synthesis	p. 30
Catalysis of Key Transformations in Carbohydrate Chemistry	p. 34
Glycosylation	p. 34
Sugar Protection and Deprotection	p. 56
Hydrolysts/Isomerizalion of Saccharides and Glycosides	p. 69
Dehydration	p. 71
Oxidation	p. 74
Other Synthetic Applications	p. 76
Conclusion	p. 83
References	p. 83
Tools in Oligosaccharide Synthesis: Current Research and Application
Introduction	p. 102
Modified Enzymes and Substrates	p. 103
Glycosidases, Glycosynthases, Thioglycosidases	p. 103
Glucansucrases	p. 105
Fructansucrase Enzymes	p. 114
Sucrose Analogues	p. 116
Oligo-and Poly-saccharide Synthesis with Sucrose Analogues	p. 118
Sucrose Isomerase	p. 119
Commercial Products	p. 122
Acknowledgment	p. 127
References	p. 127
Multivalent Lectin-Carbohydrate Interactions: Energetics and Mechanisms of Binding
Introduction	p. 140
Mucins: Background	p. 142
Binding of Lectins to Mucins	p. 145
Affinities of SBA and VML for Mucins	p. 145
Thermodynamics of SBA Binding Tn-PSM	p. 146
Thermodynamics of SBA Binding 81-mer Tn-PSM	p. 147
Thermodynamics of SBA Binding 38/40-mer Tn-PSM	p. 148
Thermodynamics of SBA Binding Fd-PSM	p. 148
Thermodynamics of VML Binding Tn-PSM	p. 149
Thermodynamics of VML Binding 81-mer Tn-PSM and 38/40-mer Tn-PSM	p. 149
Thermodynamics of VML Binding Fd-PSM	p. 150
Mechanisms of Binding of SBA and VML to PSM: The Bind and Jump Model	p. 150
Thermodynamics of Lectin-Mucin Crosslinking Interactions	p. 153
Hill Plots Show Evidence of Increasing Negative Cooperativity	p. 153
Analysis of the Stoichiometry of Binding of SBA to the Mucins	p. 153
Crosslinking of Lectins with the Mucins Correlate with Decreasing Favorable Entropy of Binding	p. 154
Conclusions and Perspective	p. 156
The Bind and Jump Model for Lectin-Mucin Interactions	p. 156
Implications of Increasing Negative Cooperativity and Decreasing Favorable Binding Entropy of Lectins-Mucin Crosslinking Interactions	p. 157
References	p. 159
Design and Creativity in Synthesis of Multivalent Neoglycoconjugates
Introduction	p. 168
Multivalency: Definition and Role	p. 168
Multivalency in Protein-Carbohydrate Interactions	p. 169
Synthesis and Applications of Multivalent Glycoconjugates	p. 171
Glycoclusters	p. 174
Glycoclusters from Branched Aliphatic Scaffolds	p. 177
Glycoclusters from Branched Aromatic Scaffolds	p. 190
Glycoclusters from Carbohydrate Scaffolds	p. 217
Glycoclusters from Peptide Scaffolds	p. 227
Other Glycoclusters	p. 233
Glycosylated Carbon-Based Nanostructures	p. 241
Glycofullerenes	p. 241
Glyconanotubes	p. 252
Multivalent Glycoconjugates by Self-Assembly	p. 265
Sell-Assembly Using Coordinating Metals	p. 266
Self-Assembly of Glycodendrons in Solution	p. 282
Glycodendrons and Glycodendrimers	p. 285
Introduction	p. 285
Glycodendrons	p. 290
Glyeodendrimers	p. 309
Conclusion	p. 354
References	p. 357
Author Index	p. 395
Subject Index	p. 423
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