Advances in Clinical Chemistry

by Makowski

• ISBN13: 9780120103416
• ISBN10: 0120103419
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-03-31
• Publisher: Elsevier Science

Summary

Volume forty-two in the internationally acclaimed Advances in Clinical Chemistry series, contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting edge microarray technology. In keeping with the tradition of the series, this volume emphasizes novel laboratory advances with application not only to both clinical laboratory diagnostics, but as well as practical basic science studies. This volume of Advances in Clinical Chemistry is an indispensable resource and practical guide for twenty-first century practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.

Table of Contents

Contributors	ix
Preface	xiii
Is Taurine a Biomarker?
Georgia Schuller-Levis
Eunkyue Park
Taurine	1	(12)
Taurine as a Biomarker	13	(3)
Conclusions	16	(7)
References	17	(6)
Application of Nanoscale Bioassemblies to Clinical Laboratory Diagnostics
Jarrod Clark
Steven S. Smith
Introduction	23	(2)
Protein Scaffolds	25	(3)
DNA Scaffolds	28	(8)
Organic Polymer Scaffolds	36	(2)
Inorganic Scaffolds	38	(3)
Discussion	41	(1)
Conclusions	42	(8)
References	42	(8)
Cardiac Troponins: Clinical and Analytical Aspects
Ravinder Sodi
Abstract	50	(1)
Introduction	50	(1)
Structure and Biochemistry of Troponins	51	(13)
Clinical Significance of Measured Cardiac Troponins	64	(12)
Measurement of Cardiac Troponins	76	(17)
Factors Affecting the Measurement of Cardiac Troponins	93	(13)
Conclusions and Future Directions	106	(17)
References	107	(16)
Leptin Physiology and Pathophysiology in the Elderly
Elena Zoico
Mauro Zamboni
Vincenzo Di Francesco
Gloria Mazzali
Francesco Fantin
Ottavio Bosello
Abstract	123	(1)
Introduction	124	(1)
Background	125	(1)
Regulation of Leptin Levels in the Elderly	126	(14)
Clinical Implications of Leptin Physiology in the Elderly	140	(1)
Leptin and the Anorexia of the Elderly	141	(1)
Leptin and Glucose Metabolism	142	(2)
Leptin, Leptin Resistance, and the Metabolic Syndrome	144	(2)
Leptin and Bone Metabolism	146	(11)
Conclusions	157	(11)
References	158	(10)
Biochemical Pathways of Wound Healing: Implications for Development of Disease-Specific Diagnostics
Nathan B. Menke
Robert F. Diegelmann
Abstract	168	(1)
Introduction	168	(1)
Acute Wound Healing	168	(11)
Chronic Wounds: Overview	179	(1)
Pressure Ulcers	179	(2)
Diabetic Ulcers	181	(1)
Venous Stasis Ulcers	182	(1)
Fibrosis	182	(1)
Modeling	183	(2)
Summary	185	(4)
References	186	(3)
Clinical Laboratory Tools to Diagnose Inflammation
Undurti N. Das
Abstract	189	(1)
Introduction	190	(10)
Mediators of Inflammation	200	(14)
Clinical Laboratory Tools to Diagnose Inflammation	214	(5)
High Sensitive-CRP and Other Proinflammatory Indices as Markers of Cardiovascular Diseases: But, Why, and How?	219	(3)
Conclusions	222	(10)
References	223	(9)
Advances in Prostate-Specific Antigen Testing
Ping Wu
Hannu Koistinen
Patrik Finne
Wan-Ming Zhang
Lei Zhu
Jari Leinonen
Ulf-Hakan Stenman
Abstract	232	(1)
Introduction	232	(1)
Prostate-Specific Antigen	233	(4)
Measurement of PSA in Circulation	237	(5)
New Approaches for Detection of PSA	242	(4)
Detection of Circulating Prostate Cancer Cells by Measurement of PSA mRNA	246	(1)
Enhancing Utility of PSA by Multivariate Methods	246	(4)
Conclusions	250	(13)
References	251	(12)
Advances in Prion Disease Surveillance
Kristen Hatcher
Carrie Harris
Pierluigi Gambetti
Shu G. Chen
Abstract	263	(1)
Introduction	264	(2)
Prion Diagnostics	266	(12)
Human Prion Disease Surveillance	278	(10)
Conclusions	288	(5)
References	289	(4)
Index	293