9780120176366

Advances in Genetics

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  • ISBN13:

    9780120176366

  • ISBN10:

    012017636X

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1997-08-15
  • Publisher: Elsevier Science
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Summary

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms theAcademic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Table of Contents

Contributors vii
The Peripheral Neuropathies and Their Molecular Genetics
1(44)
C. Bell
N. Haites
Historical Introduction
2(1)
Clinical Classification of CMT
2(2)
Genetic Classification
4(4)
Molecular Mechanisms in CMT1A
8(11)
Molecular Mechanisms of CMT1B, DSD, and CMTX1
19(2)
Myelin Proteins and Their Functional Significance
21(13)
Molecular Diagnostic Testing for CMT and HNPP
34(11)
References
36(9)
Tumor Suppressor Genes and Human Cancer
45(92)
Melissa A. Brown
Introduction
46(7)
Tumor Suppressor Genes and Their Products
53(41)
The Role of Tumor Suppressor Genes in Human Cancer
94(11)
Conclusions
105(32)
References
107(30)
Genetic Redundancy
137(20)
John F. Y. Brookfield
Introduction: The Evolutionary Background of Adaptation and Pleiotropy
138(1)
Evidence for redundancy
139(4)
Apparent and True Redundancy
143(7)
The Organism and the Cell
150(1)
Redundancy as a Fail-Safe System
151(1)
Functional Redundancy
152(1)
Conclusions
153(4)
References
153(4)
Genetics of Hybrid Inviability in Drosophila
157(30)
Pierre Hutter
Introduction
157(2)
Genetic Studies on Hybrid Inviability
159(9)
Chromosomes and genes Influencing Hybrid Viability
168(7)
Genetic Models for the Basis of Hybrid Inviability
175(4)
Conclusions
179(8)
References
181(6)
Regulation of Bacterial Gene Expression by Metals
187(52)
David J. Westenberg
Mary Lou Guerinot
Introduction
187(3)
Essential Metals
190(15)
Toxic Metals
205(21)
Concluding Remarks
226(13)
References
227(12)
Chromosome Rearrangements in Neurospora and Other Filamentous Fungi
239(160)
David D. Perkins
Introduction
241(4)
General Information Regarding Neurospora Rearrangements
245(11)
New Findings
256(21)
Rearrangements in Other Fungi
277(8)
Individual Chromosome Rearrangements of Neurospora crassa
285(97)
Summary
382(17)
References
383(16)
Index 399

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