Allogeneic Stem Cell Transplantation

by Laughlin, Mary J.; Lazarus, Hillard M., M.D.

• ISBN13: 9780896039797
• ISBN10: 089603979X
• Format: Hardcover
• Copyright: 2002-11-01
• Publisher: Humana Pr Inc

Summary

Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.

Table of Contents

Preface	v
Contributors	ix
Part I. Historical Perspective
Hematopoietic Stem Cell Transplantation: A Historical Perspective	3	(10)
Frederick R. Appelbaum
Part II. Disease Indications: Allogeneic Transplantation
Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia	13	(16)
Henry C. Fung
Stephen J. Forman
Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia	29	(18)
Partow Kebriaei
Wendy Stock
Chronic Myelogenous Leukemia	47	(10)
Edward Copelan
Allogeneic Stem Cell Transplantation for Breast Cancer	57	(12)
Abby B. Siegel
Linda T. Vahdat
Allogeneic Transplantation for the Treatment of Multiple Myeloma	69	(14)
Stefano Tarantolo
Philip J. Bierman
Non-Hodgkin's Lymphoma	83	(20)
Igor Espinoza-Delgado
Dan L. Longo
Part III. Allogeneic Graft Selection
Blood vs Marrow Allogeneic Stem Cell Transplantation	103	(14)
Daniel Anderson
Daniel Weisdorf
Haploidentical Stem Cell Transplantation	117	(12)
Hillard M. Lazarus
Jacob M. Rowe
Umbilical Cord Blood Transplantation	129	(22)
Juliet Barker
John E. Wagner
Mesenchymal Stem Cells in Allogeneic Transplantation	151	(8)
Omer N. Koc
Stanton L. Gerson
Cytokines in Allogeneic Stem Cell Mobilization	159	(10)
Ravi Vij, Randy Brown
John F. DiPersio
Nonmyeloablative Allogeneic Transplantation	169	(22)
David A. Rizzieri
Nelson J. Chao
Part IV. Supportive Care in Allogeneic Transplantation
Recent Developments in Epidemiology and Management of Invasive Fungal Infections	191	(24)
Andreas H. Groll
Thomas J. Walsh
Immune Recovery Following Allogeneic Blood Transplantation: Mechanisms of Immune Dysfunction	215	(22)
James E. Talmadge
Grading and Management of Graft-vs-Host Disease	237	(24)
Donna Przepiorka
Posttransplant EBV-Associated Disease	261	(12)
Thomas G. Gross
Brett J. Loechelt
Part V. Prevention and Management of Relapse After Allogeneic Transplantation
Allogeneic Antitumor Vaccine Strategies	273	(14)
Ginna G. Laport
Carl H. June
Donor Leukocyte Infusions	287	(24)
Robert H. Collins, Jr.
Second Hematopoietic Stem Cell Transplantation for the Treatment of Graft Failure, Graft Rejection, or Relapse	311	(16)
Steven N. Wolff
Part VI. Preclinical Studies in Allogeneic Transplantation
The Role of T Cell Depletion in Bone Marrow Transplantation	327	(16)
Yair Reisner
Massimo F. Martelli
Minimal Residual Disease in Allogeneic Recipients	343	(12)
Jerald P. Radich
Nonhuman Primate Models of Hematopoietic Stem Cell Transplantation	355	(18)
Steven M. Devine
Ronald Hoffman
In Vivo Models for the Study of Graft-vs-Host Disease and Graft-vs-Tumor Effects	373	(14)
Kai Sun
William J. Murphy
Lisbeth A. Welniak
Allogeneic Effector Cell Populations: Separating GVL from GVHD	387	(24)
Michael R. Verneris
Robert S. Negrin
Dendritic Cells: Immunobiology and Potential Use for Cancer Immunotherapy	411	(30)
David Avigan
Part VII. Epilogue
Epilogue	441	(4)
James R. Mason
Ernest Beutler
Index	445