Alzheimer's Disease : A Compendium of Current Theories

by Khachaturian, Zaven S.; Mesulam, M. Marsel

• ISBN13: 9781573312981
• ISBN10: 1573312983
• Edition: 1st
• Format: Paperback
• Copyright: 2000-12-01
• Publisher: New York Academy of Sciences

Summary

The first formal description of Alzheimer's as a distinct neuropathology began a century of research progress that has intensified in the last 20 years with a rich array of new theories, treatments, risk factors, and some possible causes. However, little

Table of Contents

Preface	ix
Zaven S. Khachaturian
M.-Marsel Mesulam
Part I. Theories on Structural Changes: Protein Synthesis, Aggregation, and Degradation
A. Pros and Cons of Amyloid
Genetic Factors in the Genesis of Alzheimer's Disease.	1	(7)
P.H. St George-Hyslop
A Very Incomplete Comprehensive Theory of Alzheimer's Disease.	8	(9)
Peter Davies
Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β-Protein.	17	(9)
Dennis J. Selkoe
The Pathogenesis of Alzheimer's Disease: Is Amyloid β-Protein the Beginning or the End?	26	(3)
Bruce A. Yankner
Pathways to Primary Neurodegenerative Disease	29	(6)
John Hardy
Arson: Tracking the Culprit in Alzheimer's Disease.	35	(4)
Mark A. Smith
James A. Joseph
George Perry
Synaptic Structure and Function in Transgenic APP Mice.	39	(3)
Karen Hsiao Ashe
B. Cytoskeleton Proteins and Synapses
A Plasticity-Based Theory of the Pathogenesis of Alzheimer's Disease.	42	(11)
M.-Marsel Mesulam
Vulnerability of Select Neuronal Types to Alzheimer's Disease.	53	(9)
Heiko Braak
KellyDel Tredici
Christian Schultz
Eva Braak
``Fatal Attractions'' of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders.	62	(6)
John Q. Trojanowski
Virginia M.-Y. Lee
The Role of Synaptic Proteins in Alzheimer's Disease.	68	(8)
Eliezer Masliah
The Long Reach of Evolution and Development: Effects on the Alzheimer Brain.	76	(5)
Kenneth S. Kosik
Part II. Theories on Functional Changes
A. Risk Factors: ApoE and Estrogen
Apolipoprotein E and Alzheimer's Disease: A Role in Amyloid Catabolism.	81	(10)
Judes Poirier
Apolipoprotein E and Alzheimer's Disease.	91	(2)
Warren J. Strittmatter
Estrogens and Estrogen-Like Non-Feminizing Compounds: Their Role in the Prevention and Treatment of Alzheimer's Disease.	93	(6)
Pattie S. Green
James W. Simpkins
Alzheimer's Disease and Some Speculations about the Evolution of Its Modifiers.	99	(5)
Robert M. Sapolsky
Caleb E. Finch
B. Trophins, Apoptosis, Proteases, and Inflammation
Comprehensive Theory of Alzheimer's Disease: The Effects of Cholesterol on Membrane Receptor Trafficking.	104	(8)
Casey Lynch
William Mobley
The Brain's Microenvironment, Early Functional Loss, and the Conversion to Alzheimer's Disease.	112	(5)
Carl W. Cotman
Aileen J. Anderson
A ``Protease Activation Cascade'' in the Pathogenesis of Alzheimer's Disease.	117	(15)
Ralph A. Nixon
A Perspective on Inflammation in Alzheimer's Disease.	132	(4)
Joseph Rogers
Yong Shen
Part III. Theories on Energetics: Circulation, Metabolism, and Oxidation
Impaired Cerebromicrovascular Perfusion: Summary of Evidence in Support of Its Causality in Alzheimer's Disease.	136	(17)
J. C. De La Torre
Existing Data Suggest That Alzheimer's Disease Is Preventable.	153	(7)
Mark P. Mattson
Oxidative Stress Leading to Loss of Critical Proteases in Alzheimer's Disease: An Alternative View of the Etiology of AD.	160	(4)
John M. Carney
Oxidative Metabolism.	164	(6)
M. Flint Beal
The Mitochondrial Spiral: An Adequate Cause of Dementia in the Alzheimer's Syndrome.	170	(14)
John P. Blass
Part IV. Epilogue
Epilogue: Toward a Comprehensive Theory of Alzheimer's Disease --- Challenges, Caveats, and Parameters.	184	(11)
Zaven S. Khachaturian
Index of Contributors	195