The Androgenic Receptors

by Perez, Dianne M.; Neve, Kim A.

• ISBN13: 9781588294234
• ISBN10: 1588294234
• Format: Hardcover
• Copyright: 2005-09-30
• Publisher: Humana Pr Inc

Summary

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

Table of Contents

Preface	v
Contributors	ix
Color Plates	xi
PART I: HISTORICAL PERSPECTIVES
1 Adrenergic Receptors: Historical Perspectives From the 20th Century
David B. Bylund	3	(22)
PART II: STRUCTURE-FUNCTION
2 Ligand Binding, Activation, and Agonist Trafficking
Angela M. Finch, Valerie Sarramegna, and Robert M. Graham	25	(62)
3 New Signal Transduction Paradigms
Kenneth P. Minneman	87	(20)
4 Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors
Michael T. Piascik, Mary Lolis Garcia-Cazarin, and Steven R. Post	107	(22)
5 Adrenergic Receptors in Clinical Medicine
Martin C. Michel and Paul A. Insel	129	(22)
PART III: IMAGING ADRENERGIC RECEPTORS AND THEIR FUNCTION
6 Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors
John C. McGrath and Craig J. Daly	151	(22)
7 Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors
Dianne M. Perez	173	(34)
PART IV: GENETICALLY ALTERED MOUSE MODELS
8 The α1- Adrenergic Receptors: Lessons From Knockouts
Paul C. Simpson	207	(34)
9 The α2-Adrenergic Receptors: Lessons From Knockouts
Christopher M. Tan and Lee E. Limbird	241	(26)
10 The β-Adrenergic Receptors: Lessons From Knockouts
Yang Xiang and Brian Kobilka	267	(26)
11 Lessons From Overexpressed Mouse Models
Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman	293	(28)
12 Adrenergic Receptor Signaling Components in Gene Therapy
Andrea D. Eckhart and Walter J. Koch	321	(18)
PART V: PHARMACOGENOMICS
13 Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms
Stephen B. Liggett	339	(26)
14 Microarray Analysis of Novel Adrenergic Receptor Functions
Boyd Rorabaugh, June Yun, and Dianne M. Perez	365	(30)
PART VI: SUMMARY AND FUTURE ENDEAVORS
15 Summary and Future Endeavors
Dianne M. Perez	395	(2)
Index	397

Excerpts

"In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary progress made in our understanding of these receptors in the twentieth century." "The Adrenergic Receptors: In the 21st Century provides researchers - through its side-by-side comparison of all the adrenergic receptors ([alpha][subscript 1], [alpha][subscript 2], and [beta]) and their subtypes - with an excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood pressure, and related pathophysiological systems."--BOOK JACKET.