Animal Lectins: A Functional View

by Loker; Eric S.

• ISBN13: 9780849372698
• ISBN10: 0849372690
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-10-09
• Publisher: CRC Press

Summary

Lectins are currently of interest in the research community because of their wide variety of properties and potential applications in pharmacology, immunology, and cancer therapy. Identifying lectins and their ligands is the particular focus of intense study. Featuring contributions from recognized experts, Animal Lectins: A Functional Viewpresents up-to-date knowledge of the biological roles of animal lectins, including glycoprotein folding, sorting, and targeting; cell adhesion; embryogenesis; cell-cell interactions and signaling; as well as recognition and effector functions in innate immunity. This book also explores the structural basis of protein-carbohydrate interactions.

Table of Contents

Foreword	p. xi
Preface	p. xiii
Editors	p. xv
Contributors	p. xvii
Introduction
Introduction to Animal Lectins	p. 3
Modern Approaches for Assessing Lectin Function
Structural Aspects of Lectin-Ligand Interactions	p. 13
Thermodynamic Approaches to the Study of Affinity of Clustered Carbohydrate Epitopes in Galectin-Glycoconjugate Interactions	p. 33
Deciphering Lectin Ligands through Glycan Arrays	p. 49
Chromatography and Related Approaches for Qualitative and Quantitative Analyses of Lectin Specificity	p. 63
Analysis of Whole-Genome and Other Data Resources to Characterize the Molecular, Structural, and Evolutionary Diversity of C-Type Lectins and Discover New Genes	p. 75
Animal Models for Assessing the Biological Roles of Lectins	p. 85
Glycoprotein Folding, Sorting and Secretion, Targeting, Degradation, and Clearance
Calreticulin and Calnexin as Chaperones in Glycoprotein Folding	p. 117
Role of L-Type Lectins in Glycoprotein Sorting and Trafficking	p. 133
P-Type Lectins and Lysosomal Enzyme Targeting	p. 147
M-Type Lectins as Novel Components of Secretory Pathways	p. 165
Functional Aspects of the Hyaluronan and Chondroitin Sulfate Receptors	p. 171
Cell Adhesion and Cell Surface Lattice Formation
Galectin-3 and Cancer	p. 195
Myelin-Associated Glycoprotein (Siglec-4): A Nervous System Lectin That Regulates Axon-Myelin Stability and Axon Regeneration	p. 207
Hyaluronan-Binding Proteoglycans	p. 223
Roles of Coral Lectins in Morphological Change of Zooxanthellae	p. 233
Cell-Cell Interactions, Signaling, and Transport
Siglecs: Roles in Cell-Cell Interactions and Signaling	p. 243
Signaling through the Fungal [beta]-Glucan Receptor Dectin-1	p. 255
CD22: A Regulator of B Cell Survival and Signal Transduction	p. 265
Galectins and Integrins in Pre-B Cell Development	p. 275
Golgi N-Glycan Processing and Galectin Functions	p. 285
Recognition and Effector Functions in Innate Immunity
Mannan-Binding Lectin Polymorphisms and Infectious Diseases	p. 303
Immunoregulatory Roles of Lung Surfactant Proteins A and D	p. 333
C-Type Lectin Receptors on Dendritic Cells	p. 351
Structural and Functional Roles of C-Type Lectin Receptors on Natural Killer Cells	p. 363
Activation of Lepidopteran Insect Innate Immune Responses by C-Type Immulectins	p. 383
Galectins as Novel Regulators of Immune Cell Homeostasis and Inflammation	p. 397
Interactions of Galectins with Leukocytes	p. 417
Regulation of Immune Responses by Galectin-3	p. 435
X-Lectins: A New Family with Homology to the Xenopus laevis Oocyte Lectin XL-35	p. 449
F-Type Lectins: A New Family of Recognition Factors	p. 465
Biology of FREPs: Diversified Lectins with Fibrinogen-Related Domains from Freshwater Snail Biomphalaria glabrata	p. 475
Lectins in Sand Fly-Leishmania Interactions	p. 493
Ficolins: The Structural Basis for Recognition Plasticity	p. 505
Hemolytic Lectin in Marine Invertebrates	p. 517
Structure-Function Relationship in Mammalian Chitinase-Like Lectins	p. 531
Index	p. 547
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