Annual Reports in Medicinal Chemistry

by Hagmann; Doherty

• ISBN13: 9780120405350
• ISBN10: 0120405350
• Edition: 1st
• Format: Paperback
• Copyright: 2000-08-24
• Publisher: Elsevier Science

Summary

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market. * Critical reviews of the previous year's literature in many topics of interest to medicinal chemists* Highlights major developments in medicinal chemistry* Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes

Table of Contents

Contributors	ix
Preface	xi
I. CENTRAL NERVOUS SYSTEM DISEASES
Section Editor
David W. Robertson
Metabotropic Glutamate Receptor Modulators: Recent Advances and Therapeutic Potential	1	(10)
James A. Monn
Darryle D. Schoepp
Recent Advances in Selective Serotonin Receptor Modulation	11	(10)
Albert J. Robichaud
Brian L. Largent
Recent Advances in the Development of Novel Analgesics	21	(10)
Elizabeth A. Kowaluk
Kevin J. Lynch
Michael F. Jarvis
Secretase Inhibitors as Therapeutics for Alzheimer's Disease	31	(10)
Richard E. Olson
Lorin A. Thompson
Targeting Nicotinic Acetylcholine Receptors: Advances in Molecular Design and Therapies	41	(12)
Jeffrey D. Schmitt
Merouane Bencherif
II. CARDIOVASCULAR AND PULMONARY DISEASES
Section Editor
William J. Greenlee
Recent Developments in Antitussive Therapy	53	(10)
John A. Hey
Neng-Yang Shih
Advances in the Understanding and Treatment of Congestive Heart Failure (HF)	63	(10)
John E. Macor
Mark C. Kowala
Recent Advances in Endothelin Antagonism	73	(10)
Gang Liu
Factor Xa Inhibitors: Recent Advances in Anticoagulant Agents	83	(20)
Bing-Yan Zhu
Robert M. Scarborough
Antiplatelet Therapies	103	(20)
Joanne M. Smallheer
Richard E. Olson
Ruth R. Wexler
III. CANCER AND INFECTIOUS DISEASES
Section Editor
Jacob J. Plattner
Anti-angiogenesis as a Therapeutic Strategy for Cancer	123	(12)
Wendy J. Fantl
Steven Rosenberg
Progress in the Oxazolidinone Antibacterials	135	(10)
Robert C. Gadwood
Dean A. Shinabarger
Progress in Macrolide and Ketolide Antibacterials	145	(12)
Daniel T. W. Chu
Progress with Antifungal Agents and Approaches to Combat Fungal Resistance	157	(10)
William J. Watkins
Thomas E. Renau
Matrix Metalloproteinase Inhibitors for Treatment of Cancer	167	(10)
Jerry W. Skiles
Lauren G. Monovich
Arco Y. Jeng
Recent Developments in Antiretroviral Therapies	177	(14)
Tomas Cihlar
Norbert Bischofberger
IV. IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC DISEASES
Section Editor
William K. Hagmann
Chemokines: Targets for Novel Therapeutics	191	(10)
Bharat K. Trivedi
Joseph E. Low
Kenneth Carson
Gregory J. LaRosa
Inosine Monophosphate Dehydrogenase: Consideration of Structure, Kinetics, and Therapeutic Potential	201	(10)
Jeffrey O. Saunders
Scott A. Raybuck
Recent Advances in Therapeutic Approaches to Type 2 Diabetes	211	(10)
John M. Nuss
Allan S. Wagman
Toward the Development of α1a Adrenergic Receptor Antagonists	221	(10)
Mark G. Bock
Michael A. Patane
Protein Tyrosine Phosphatase Inhibition	231	(20)
William C. Ripka
Cholesteryl Ester Transfer Protein as a Potential Therapeutic Target to Improve the HDL to LDL Cholesterol Ratio	251	(10)
James A. Sikorski
Kevin C. Glenn
V. TOPICS IN BIOLOGY
Section Editor
Janet Allen
Phamacogenetics	261	(10)
Kit Fun Lau
Hakan Sakul
Oligomerisation of G Protein-Coupled Receptors	271	(10)
Stephen Rees
Immunomodulatory Phosphorylcholine-Containing Proteins Secreted by Filarial Nematodes: Novel Approaches to Identify Targets to Regulate the Immune System	281	(8)
William Harnett
VI. TOPICS IN DRUG DESIGN AND DISCOVERY
Section Editor
George L. Trainor
Privileged Structures-An Update	289	(10)
Arthur A. Patchett
Ravi P. Nargund
Ex Vivo Approaches to Predicting Oral Pharmacokinetics in Humans	299	(10)
Barbra H. Stewart
Yi Wang
Narayanan Surendran
Inhibition of Cysteine Proteases	309	(12)
Robert W. Marquis
Principles for Multivalent Ligand Design	321	(10)
Laura L. Kiessling
Laura E. Strong
Jason E. Gestwicki
VII. TRENDS AND PERSPECTIVES
Section Editor: Annette M. Doherty Institut de Recherche Jouveinal/Parke-Davis Fresnes, France
To Market, To Market-1999	331	(26)
Patrick Berna
Bernard Gaudilliere
Genetically Modified Crops as a Source for Pharmaceuticals	357	(8)
Veronique Gruber
Manfred Theisen
Compound Name, Code Number and Subject Index, Volume 35	365	(10)
Cumulative Chapter Titles Keyword Index, Volumes 1-35	375	(16)
Cumulative NCE Introduction Index, 1983-1999	391	(16)
Cumulative NCE Introduction Index, 1983-1999, By Indication	407	(19)
Application Form for New ACS Membership	426