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Series Preface | p. ix |
Preface | p. xi |
Author | p. xiii |
Introduction to Biopharmaceutical Conformational Analysis: Issues and Methods | p. 1 |
References | p. 5 |
Comparability of Biotechnological/Biological Products and Biological Generics | p. 19 |
References | p. 29 |
Application of Native Electrophoresis for the Study of Protein Conformation | p. 37 |
References | p. 41 |
Affinity Chromatography Including Hydrophobic Interaction Chromatography in the Study of Biopolymer Conformation | p. 49 |
References | p. 64 |
Size-Exclusion Chromatography and Biomolecular Conformation | p. 77 |
References | p. 83 |
Use of Analytical Ultracentrifugation to Study Biomolecular Conformation | p. 87 |
References | p. 91 |
Use of Differential Scanning Calorimetry to Measure Conformational Change in Proteins and Other Biomacromolecules | p. 97 |
References | p. 104 |
Light Scattering and Biomacromolecular Conformation | p. 111 |
References | p. 121 |
Use of Luminescence to Measure Conformational Change in Biopharmaceuticals with Emphasis on Protein and Protein Drug Products | p. 131 |
References | p. 150 |
Near-Infrared Spectroscopy and Macromolecular Conformation | p. 163 |
References | p. 166 |
Use of Mid-Infrared and Fourier Transform Infrared Spectroscopy to Study Conformation of Biomacromolecules | p. 175 |
References | p. 183 |
Use of Raman Spectroscopy to Evaluate Biopharmaceutical Conformation | p. 191 |
References | p. 193 |
Use of U V-VIS Spectrophotometry for the Characterization of Biopharmaceutical Products | p. 197 |
References | p. 201 |
Use of Optical Rotatory Dispersion and Circular Dichroism to Study Therapeutic Biomacromolecule Conformation | p. 207 |
References | p. 210 |
Use of Nuclear Magnetic Resonance for the Characterization of Biotherapeutic Products | p. 215 |
References | p. 219 |
Use of Chemical Probes for the Study of Protein Conformation | p. 223 |
References | p. 234 |
Use of Hydrogen Exchange in the Study of Biopharmaceutical Conformation | p. 241 |
References | p. 245 |
Use of Chemical Modification for the Conformational Analysis of Biopharmaceuticals | p. 251 |
References | p. 281 |
Use of Immunology to Characterize Biopharmaceutical Conformation | p. 299 |
References | p. 307 |
Use of Limited Proteolysis to Study the Conformation of Proteins of Biotechnological Interest | p. 317 |
References | p. 321 |
Other Technologies for the Characterization of Conformational Change in Biopharmaceuticals | p. 327 |
p. 327 | |
Small-Angle Neutron Scattering and Small-Angle X-Ray Scattering | p. 329 |
Equilibrium Dialysis | p. 330 |
Enzyme Kinetics | p. 330 |
References | p. 333 |
Development of an Experimental Approach for the Study of the Conformation of a Biological Therapeutic Product | p. 341 |
References | p. 344 |
Index | p. 349 |
Table of Contents provided by Ingram. All Rights Reserved. |
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The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.