Ever caught yourself screaming, "I could just kill that teacher"? What would it take to justify such antisocial behavior and weeks of detention? Especially if he's the best teacher you've ever had? Giving you an "F" on a quiz? Mispronouncing your name during roll call...again? How about blowing up the moon and threatening to do the same to Mother Earth—unless you take him out first?! Plus a reward of a cool 100 million from the Ministry of Defense! Okay, now that you're committed... How are you going to pull this off? What does your pathetic class of misfits have in their arsenal to combat Teach's alien technology, bizarre powers and...tentacles?!
The 3-E students discover that Koro Sensei's greatest weakness might be a common substance. Will they be able to use it to assassinate him while he helps Meg, formerly of the varsity swim team, with her greatest weakness? The next assassination attempt, implemented by Terasaka, is more elaborate but endangers his fellow students. Can he save them without saving his target? Then, the top class at school, including Principal Asano's son, conspires to prevent 3-E from ever rising closer to the top!