Bacterial Secreted Proteins : Secretory Mechanisms and Role in Pathogenesis

by Wooldridge, Karl

• ISBN13: 9781904455424
• ISBN10: 1904455425
• Format: Hardcover
• Copyright: 2009-03-02
• Publisher: Intl Specialized Book Service Inc

Summary

Secreted proteins are particularly important in bacterial pathogenesis. These proteins have a range of biological functions from host cell toxicity to more subtle alterations of the host cell for the benefit of the invader. The importance of protein secretion to bacterial pathogens is exemplified by the array of mechanisms that have evolved for this purpose. This extensive publication on bacterial secreted proteins, the secretory systems of bacteria and the vital role of secreted proteins in bacterial pathogenesis will be of immense value to all microbiologists, molecular biologists, public health scientists and researchers engaged in the study of pathogenesis, drug design and vaccine development. A skillful selection of topics and a panel of acknowledged experts as authors have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, specialized mechanisms for secretion across the Gram-negative outer membrane, systems for transport across both membranes of Gram-negative bacteria, protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili and a chapter on the less well defined pathways. Section 2 describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each chapter of the book can be read in isolation, particularly the chapters in section 2. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. A recommended reference volume for all microbiology libraries.

Table of Contents

List of contributors	p. v
Preface	p. xi
Part 1
The Sec Protein Secretion System	p. 3
The Twin-arginine Translocation Pathway	p. 23
Type I Bacterial Secretion Systems	p. 45
Type II Secretory System (T2SS) in Gram-negative Bacteria: a Molecular Nanomachine for Secretion of Sec and Tat-dependent Extracellular Proteins	p. 67
The Type III Secretion System	p. 93
Mechanistic and Structural Analysis of Type IV Secretion Systems	p. 117
Type V Secretion	p. 139
Assembly and Secretion of Surface Fibres in Gram-Negative Bacteria	p. 159
Secretome Mapping in Gram-positive Pathogens	p. 193
Non-classical Secretion	p. 225
Part 2
Secreted Proteins and Virulence in Salmonella enterica	p. 239
Secreted and Exported Proteins Important to Mycobacterium tuberculosis Pathogenesis	p. 265
Protein Secretion and the Pathogenesis of Campylobacter jejuni	p. 299
Listeria monocytogenes	p. 313
Protein Secretion and Pathogenesis in Neisseria meningitidis	p. 347
The Role of Secreted Proteins in the Pathogenesis of Helicobacter pylori Infection	p. 361
Protein Secretion in Legionella pneumophila	p. 401
Bordetella pertussis	p. 413
Secreted Proteins of Vibrio cholerae	p. 433
The Secreted Proteins of Pseudomonas aeruginosa: Their Export Machineries and How They Contribute to Pathogenesis	p. 451
Secretion systems of the enterobacterial phytopathogen, Erwinia	p. 479
Index	p. 505
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