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Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, Fourth Edition What you Need to Know for Each Drug Class, Fourth Edition

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Edition:
4th
ISBN13:

9780071741040

ISBN10:
0071741046
Format:
Paperback
Pub. Date:
4/18/2011
Publisher(s):
McGraw-Hill Professional
List Price: $53.55

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Summary

A proven method for learning the most difficult-to-understand concepts in pharmacologyGreat for USMLE review!Basic Concepts in Pharmacologyprovides students with a complete framework for studying the fundamental principles of drug actions. This unique study system helps students set priorities, minimize memorization, and reduce stress.The book includes study techniques not found in any other book and details exactly what student need to know about each drug class to pass the course and the USMLE.Features Simplifies the learning process by presenting drugs by class Reinforces essential concepts and definitions Written in a conversational engaging style Organizes and condenses must-know drug information NEW larger trim size Numerous summary tables, illustrations, and boxes encapsulate key conceptsThe content you need to understand essential pharmacology material: Chapter 1. Where to Start; Part 1: General Principles; Chapter 2. Receptor Theory; Chapter 3. Absorption, Distribution and Clearance; Chapter 4. Pharmacokinetics; Chapter 5. Drug Metabolism and Renal Elimination; Part II: Autonomics; Chapter 6. Review of the Autonomic Nervous System; Chapter 7. Cholinergic Agonists; Chapter 8. Cholinergic Antagonists; Chapter 9. Adrenergic Agonists; Chapter 10. Adrenergic Antagonists; Part III: Drugs That Affect the Cardiovascular System; Chapter 11. Drugs that Improve Cardiac Contractility; Chapter 12. Antihypertensive Drugs; Chapter 13. Drugs that Treat Heart Failure; Chapter 14. Antiarrrhytmic Drugs; Chapter 15. Drugs that Affect Blood; Chapter 16. Lipid-Lowering Drugs; Part IV: Drugs Acting on the Central Nervous System; Chapter 17. Anxiolytic and Hynotic Drugs; Chapter 18. Antidepressants and Lithium; Chapter 19. Antipsychoyics or Neuroleptics; Chapter 20. Drugs Used in Parkinson's Disease; Chapter 21. Antiepileptic Drugs; Chapter 22 Narcotics; Chapter 23. General Anesthetics; Chapter 24. Local Anesthetics; Chapter 25. Introduction to Chemotherapy; Chapter 26. Inhibitors of Cell Wall Synthesis; Chapter 27. Proteins Synthesis Inhibitors; Chapter 28. Folate Anatgonists; Chapter 29. Quinolones and Urinary Tract Antiseptics; Chapter 30. Drugs Used in Tuberculosis and Leprosy; Chapter 31. Antifungal Drugs; Chapter 32. Anthelmintic Drugs; Chapter 33. Antiviral Drugs; Chapter 34. Antiprotozoal Drugs; Chapter 35. Anticancer Drugs; Part VI: Drugs that Affect the Endocrine System; Chapter 36. Andrenocortical Hormones; Chapter 37. Sex Steroids; Chapter 38. Thyroid and Antithyroid Drugs Chapter 39. Insulin, Glucagon and Oral Hypoglycemic Drugs; Part VII: Miscellaneous Drugs; Chapter 40. Histamine and Antihistamines; Chapter 41. Respiratory Drugs; Chapter 42. Drugs that Affect the GI Tract; Chapter 43. Nonnarcotic Analgesics and Anti-Inflammatory Drugs; Chapter 44. Immunosuppressives; Chapter 45. Drugs Used in Osteoporosis; Chapter 46. Toxicology and poisoning.

Table of Contents

Prefacep. xiii
Where To Startp. 1
General Principles
Receptor Theoryp. 5
Agonistsp. 5
Efficacy and Potencyp. 6
Therapeutic Indexp. 7
Antagonistsp. 7
Inverse Agonistsp. 9
Absorption, Distribution, and Clearancep. 11
First-Pass Effectp. 11
How Drugs Cross Membranesp. 11
Bioavailabilityp. 13
Total Body Clearancep. 14
Pharmacokineticsp. 16
Volume of Distributionp. 16
First-Order Kineticsp. 17
Zero-Order Kineticsp. 19
Steady-State Concentrationp. 20
Time Needed to Reach Steady Statep. 21
Loading Dosep. 22
Drug Metabolism and Renal Eliminationp. 24
Liver Metabolismp. 24
Renal Excretionp. 25
Drugs That Affect the Autonomic Nervous System
Review of the Autonomic Nervous Systemp. 29
Why Include This Material?p. 29
Relevant Anatomyp. 30
Synthesis, Storage, Release, and Removal of Transmittersp. 32
Receptorsp. 34
General Rules of Innervationp. 35
Presynaptic Receptorsp. 37
Cholinergic Agonistsp. 38
Organization of Classp. 38
Direct Cholinergic Agonistsp. 39
Cholinesterase Inhibitorsp. 40
Cholinergic Antagonistsp. 43
Organization of Classp. 43
Muscarinic Antagonistsp. 43
Ganglionic Blockersp. 45
Neuromuscular Blockersp. 45
Adrenergic Agonistsp. 47
Organization of Classp. 47
Direct-Acting Agonistsp. 48
Dopaminep. 49
Indirect-Acting Agentsp. 50
Cardiovascular Effects of Norepinephrine, Epinephrine, and Isoproterenolp. 50
Adrenergic Antagonistsp. 52
Organization of Classp. 52
Central Blockersp. 52
-Blockersp. 52
-Blockersp. 54
Mixed - and -Blockersp. 55
Drugs That Affect the Cardiovascular System
Antihypertensive Drugsp. 59
Organization of Classp. 59
Diureticsp. 60
Drugs That Interfere With the Renin-Angiotensin Systemp. 62
Angiotensin-Converting Enzyme (ACE) Inhibitorsp. 62
Angiotensin II Receptor Blockers (ARBs)p. 63
Selective Aldosterone Receptor Antagonistsp. 64
Direct Renin Inhibitor (DRI)p. 64
Calcium Channel Blockersp. 64
Nitratesp. 65
Other Direct Vasodilatorsp. 66
- and -Blockersp. 66
Clonidinep. 67
Drugs Used in Ischemic Heart Disease and Congestive Heart Failurep. 69
Ischemic Heart Diseasep. 69
Congestive Heart Failurep. 69
Reduction of Cardiac Workloadp. 70
Control of Excessive Fluidp. 70
Enhancement of Contractilityp. 71
Cardiac Glycosidesp. 71
Sympathomimeticsp. 72
Phosphodiesterase Inhibitorsp. 72
Ranolazinep. 72
Antiarrhythmic Drugsp. 73
Organization of Classp. 73
Drugs (Sodium Channel Blockers)p. 74
Drugs (-Blockers)p. 75
Drugs (Potassium Channel Blockers)p. 76
Drugs (Calcium Channel Blockers)p. 77
Other Antiarrhythmic Drugsp. 78
Drugs That Increase Heart Ratep. 78
Drugs that Affect Bloodp. 79
Organization of Classp. 79
Antiplatelet Agentsp. 79
Anticoagulantsp. 81
Thrombolytic Drugsp. 83
Phosphodiesterase Inhibitorsp. 84
Drugs Used in the Treatment of Anemiap. 84
Lipid-Lowering Drugsp. 86
Organization of Classp. 86
Additional Explanation of Mechanismsp. 87
Drugs that Act on the Central Nervous System
Drugs Used in Dementiap. 91
Organization of Classp. 91
Cholinesterase Inhibitorsp. 91
NMDA Blockerp. 92
Anxiolytic and Hypnotic Drugsp. 93
Tolerance and Dependencep. 93
Organization of Classp. 94
Barbituratesp. 95
Benzodiazepinesp. 96
Buspironep. 98
Benzodiazepine Receptor Agonistsp. 98
Melatonin Receptor Agonistp. 98
Drugs Used in Mood Disordersp. 100
Organization of Classp. 100
Serotonin-Specific Reuptake Inhibitors (SSRIs)p. 101
Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)p. 102
Heterocyclics/TCAsp. 102
Monoamine Oxidase (MAO) Inhibitorsp. 103
Other Antidepressantsp. 104
Drugs Used in Bipolar Disorderp. 105
Antipsychotics or Neurolepticsp. 106
Organization of Classp. 106
Typical Antipsychotics (First Generation)p. 107
Serotonin-Dopamine Antagonists (Second Generation)p. 108
Neuroleptic Malignant Syndromep. 109
Drugs Used in Parkinson Diseasep. 110
Organization of Classp. 110
Dopamine Replacement Therapyp. 111
Dopamine Agonist Therapyp. 112
Anticholinergic Therapyp. 112
Antiepileptic Drugsp. 113
Organization of Classp. 113
Important Details About the Most Important Drugsp. 114
Other Drugs to Considerp. 115
Narcotics (Opiates)p. 117
Organization of Classp. 117
Actions of Morphine and the Other Agonistsp. 118
Distinguishing Features of Some Agonistsp. 119
Opioid Antagonistsp. 120
Opioid Agonist-Antagonistsp. 121
General Anestheticsp. 122
Organization of Classp. 122
Uptake and Distribution of Inhalational Anestheticsp. 123
Elimination of Inhalational Anestheticsp. 124
Potency of General Anestheticsp. 124
Specific Gases and Volatile Liquidsp. 124
Specific Intravenous Agentsp. 125
Local Anestheticsp. 126
Organization of Classp. 126
Mechanism of Actionp. 127
Special Features About Individual Agentsp. 127
Chemotherapeutic Agents
Introduction to Chemotherapyp. 131
Approach to the Antimicrobialsp. 131
General Principles of Therapyp. 131
Definitionsp. 132
Important Concepts to Understandp. 132
Classification of Antimicrobialsp. 134
Inhibitors of Cell Wall Synthesisp. 136
General Featuresp. 136
-Lactamsp. 136
Penicillinsp. 138
Cephalosporinsp. 139
Carbapenemsp. 140
Monobactams (Aztreonam)p. 140
Other Inhibitors of Cell Wall Synthesisp. 141
Vancomycinp. 141
Bacitracinp. 141
Fosfomycinp. 141
Daptomycinp. 141
Protein Synthesis Inhibitorsp. 142
General Featuresp. 142
Aminoglycosidesp. 142
Tetracyclinesp. 143
Macrolidesp. 144
Streptogramins and Oxazolidinonesp. 145
Chloramphenicolp. 146
Clindamycinp. 146
Folate Antagonistsp. 147
Mechanism of Actionp. 147
Selected Featuresp. 148
Quinolones and Urinary Tract Antisepticsp. 149
Drugs in This Groupp. 149
Quinolonesp. 149
Methenaminep. 150
Drugs Used in Tuberculosis and Leprosyp. 151
Organization of Classp. 151
Isoniazidp. 152
Rifampinp. 152
Pyrazinamidep. 153
Ethambutolp. 153
Dapsonep. 153
Antifungal Drugsp. 155
Organization of Classp. 155
Azole Antifungalsp. 156
Polyene Antifungalsp. 157
Echinocandinsp. 158
Terbinafinep. 158
Anthelmintic Drugsp. 159
Organization of Classp. 159
Drugs Used Against Cestodes and Trematodesp. 159
Drugs Used Against Nematodesp. 160
Drugs Used Against Filariap. 160
Antiviral Drugsp. 162
Organization of Classp. 162
Anti-HIV Drugsp. 163
Drugs Used in Influenzap. 164
Other Antiviralsp. 165
Antiprotozoal Drugsp. 166
Organization of Classp. 166
Metronidazolep. 167
Antimalarial Agentsp. 167
Therapeutic Considerationsp. 168
Special Featuresp. 168
Anticancer Drugsp. 170
Organization of Classp. 170
Terminology and General Principles of Therapyp. 171
Adverse Effectsp. 173
Cytotoxic Drugsp. 174
Alkylating Agentsp. 174
Antimetabolitesp. 175
Antibiotics and Other Natural Productsp. 176
Antibodiesp. 178
Other Cytotoxic Drugsp. 178
Hormonal Agentsp. 179
Kinase Inhibitorsp. 180
Miscellaneous Agentsp. 180
Drugs That Affect the Endocrine System
Adrenocortical Hormonesp. 185
Organization of Classp. 185
Glucocorticoidsp. 187
Mineralocorticoidsp. 188
Inhibitors of Adrenocorticoid Synthesisp. 188
Sex Steroidsp. 189
Organization of Classp. 189
Estrogensp. 191
Antiestrogensp. 191
Progestinsp. 192
Antiprogestinsp. 192
Oral Contraceptivesp. 192
Androgensp. 193
Antiandrogensp. 194
GnRH Agonists and Antagonistsp. 194
PDE5 Inhibitorsp. 195
Thyroid and Parathyroid Drugsp. 196
Organization of Classp. 196
Thyroid Replacement Therapyp. 197
Drugs That Are Thyroid Downersp. 197
Parathyroid Drugsp. 197
Insulin, Glucagon, and Oral Hypoglycemic Drugsp. 199
Organization of Classp. 199
Insulinsp. 200
Oral Hypoglycemic Agentsp. 201
Miscellaneous Drugs
Histamine and Antihistaminesp. 205
Organization of Classp. 205
H1 Receptor Antagonistsp. 205
Respiratory Drugsp. 208
Organization of Classp. 208
-Agonistsp. 209
Leukotriene Modifiersp. 209
Methylxanthinesp. 210
Cholinergic Antagonistsp. 210
Cromolyn and Omalizumabp. 210
Pulmonary Hypertensionp. 210
Drugs that Affect the GI Tractp. 212
Organization of Classp. 212
Drugs That Act in the Upper GI Tractp. 212
Drugs That Act in the Lower GI Tractp. 213
Nonnarcotic Analgesics and Anti-Inflammatory Drugsp. 216
Organization of Classp. 216
Nonsteroidal Anti-Inflammatory Drugsp. 216
Cox-2 Inhibitorsp. 218
Salicylates, Including Aspirinp. 218
Acetaminophenp. 220
Other Drugs for Arthritisp. 220
Antigout Agentsp. 221
Drugs Used in the Treatment of Headachesp. 222
Immunosuppressivesp. 223
Organization of Classp. 223
Calcineurin Inhibitorsp. 223
Mycophenolate Mofetil and Azathioprinep. 224
Monoclonal Antibodiesp. 224
Drugs Used in Osteoporosisp. 225
Organization of Classp. 225
Bisphosphonatesp. 226
Selective Estrogen Receptor Modulatorsp. 226
Estrogensp. 226
Parathyroid Hormonep. 227
Calcitoninp. 227
Other Agentsp. 227
Toxicology and Poisoningp. 228
Principles of Toxicologyp. 228
General Principles in the Treatment of Poisoningp. 228
Specific Antidotesp. 229
Indexp. 231
Table of Contents provided by Ingram. All Rights Reserved.


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