The Basic Science of Oncology

by Tannock, Ian; Hill, Richard; Bristow, Robert; Harrington, Lea

• ISBN13: 9780071387743
• ISBN10: 0071387749
• Edition: 4th
• Format: Paperback
• Copyright: 2005-02-28
• Publisher: McGraw-Hill Professional

Summary

This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments.

Author Biography

Ian F. Tannock, MD, PhD
Daniel E. Bergsagel Professor of Medical Oncology
Princess Margaret Hospital
University Health Network
Professor of Medicine and Medical Biophysics
University of Toronto
Senior Scientist, Division of Experimental Therapeutics
Ontario Cancer Institute
Toronto, Ontario, Canada

Richard P. Hill, PhD
Senior Scientist, Division of Experimental Therapeutics
Ontario Cancer Institute
Professor, Departments of Medical Biophysics and Radiation Oncology
University of Toronto

Robert G. Bristow, MD, PhD
Assistant Professor
Departments of Radiation Oncology and Medical Biophysics
University of Toronto
Associate Scientist, Division of Experimental Therapeutics
Ontario Cancer Institute

Lea Harrington, PhD
Senior Scientist, Division of Cellular & Molecular Biology
Ontario Cancer Institute/ Amgen Institute
Assistant Professor, Department of Medical Biophysics
University of Toronto

The authors represent the premier cancer research center in Canada. The contributors are primarily located at the Ontario Cancer institute as well.

Table of Contents

Contributors	vii
Preface	xi
Introduction to Cancer Biology	1	(3)
Lea Harrington
Robert G. Bristow
Richard P. Hill
Ian F. Tannock
Cancer Epidemiology	4	(21)
John McLaughlin
Steven Gallinger
Chemical and Radiation Carcinogenesis	25	(24)
Allan B. Okey
Patricia A. Harper
Denis M. Grant
Richard P. Hill
Methods of Molecular Analysis	49	(28)
Suzanne Kamel-Reid
Cheryl H. Arrowsmith
Patricia P. Reis
Jeremy A. Squire
Genomic Stability and DNA Repair	77	(23)
Robert G. Bristow
Lea Harrington
Viruses and Cancer	100	(23)
Christopher D. Richardson
Oncogenes and Tumor Suppressor Genes	123	(19)
Sara Oster
Linda Penn
Vuk Stambolic
Cellular Signaling	142	(25)
Melanie A. McGill
C. Jane McGlade
Cell Proliferation and Tumor Growth	167	(27)
Jeffrey C.H. Donovan
Joyce Slingerland
Ian F. Tannock
Cell Death	194	(11)
Razqallah Hakem
Lea Harrington
Tumor Progression and Metastasis: Cellular, Molecular, and Microenvironmental Factors	205	(26)
Rama Khokha
Evelyn Voura
Richard P. Hill
Angiogenesis	231	(18)
Celina Sturk
Daniel Dumont
Imaging in Oncology	249	(12)
Michael D. Sherar
Molecular and Cellular Basis of Radiotherapy	261	(28)
Robert G. Bristow
Richard P. Hill
The Scientific Basis of Radiotherapy	289	(33)
Richard P. Hill
Robert G. Bristow
Pharmacology of Anticancer Drugs	322	(27)
Lillian L. Siu
Malcolm J. Moore
Cellular and Molecular Basis of Drug Treatment for Cancer	349	(27)
Michael J. Boyer
Ian F. Tannock
Drug Resistance	376	(24)
Susan P.C. Cole
Ian F. Tannock
Hormones and Cancer	400	(31)
Paul Rennie
Jason Read
Leigh Murphy
Cancer and the Immune System	431	(22)
Nancy N. Berg-Brown
Linh T. Nguyen
Pamela S. Ohashi
Biological Therapy of Cancer	453	(32)
Neil L. Berinstein
Guide to Studies of Diagnostic Tests, Prognostic Factors, and Treatments	485	(24)
David C. Hodgson
Ian F. Tannock
Glossary	509	(20)
Index	529