Biochemical Pharmacology of Blood and Bloodforming Organs

by Fisher, James W.; Agrawal, K. (CON); Beckman, B. S. (CON); Capizzi, R. L. (CON); Dugdale, M. (CON)

• ISBN13: 9783642758676
• ISBN10: 3642758673
• Edition: Reprint
• Format: Paperback
• Copyright: 2012-01-19
• Publisher: Springer Verlag

Summary

The subject of this volume is to review chemical agentswhich affect blood and blood-forming organs. Significant ad-vances made over the past several years in the purificationof several hematopoietic growth factors, such as erythro-poietin and colony stimulating factor; the availability ofseveral other growth factors, such as the interleukins whichare important in regulating the production of red bloodcells, leukocytes, megakaryocytes and platelets are discus-sed. Numerous toxic chemical substances are being producedin our environment which people are exposed todaily causinga suppression of erythropoiesis, myelopoiesis and megakaryo-cytopoiesis. Attempts to evaluate both the therapeutic roleof some of the newer growth factors, such as erythropoietinin the anemia of end stage disease, as well as colony stimu-lating factors in somehematopoietic abnormalities are alsocovered in this volume. In addition, numerous chemical fac-tors in our environment which suppress major hematopoieticlineages stimulated by erythropoietin, macrophage colonystimulating factor, granulocyte colony stimulating factor,interleukin 1-alpha, 1-beta, 2,3,4,5,6, and 7 are also in-cluded. In addition, chapters on the use of erythropoietinin the treatment of anemia of end stage renal disease canprovide the practicing hematologist and nephrologist withupdated information on the use of erythropoietin for thisdisease. The book includes chapters on the fundamental con-trol of hematopoiesis and other mechanisms of action oferythropoietin, and finally an up-to-date overview of thechemotherapy of leukemia. This book will prove useful to in-vestigators in the fields of pharmacology, physiology,nephrology, urology, hematology, pathology, endocrinology,biochemistry, and molecular and cell biology.