Biofilm Eradication and Prevention A Pharmaceutical Approach to Medical Device Infections

by Shunmugaperumal , Tamilvanan

• ISBN13: 9780470479964
• ISBN10: 0470479965
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-09-07
• Publisher: Wiley

Summary

Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

Author Biography

Tamilvanan Shunmugaperumal, PhD, works in the Department of Pharmaceutical Technology at the International Medical University in Kuala Lumpur, Malaysia. His current research seeks to exploit the potential of lipid- and polymer-based drug delivery carriers to eradicate infectious biofilm formation associated with both medical devices and human organs.

Table of Contents

Preface	p. ix
Acknowledgments	p. xii
Development and Characterization of Biofilms	p. 1
Introduction and Overview of biofilm	p. 3
Rationale For Biofilm Eradication From Modern Medical Devices	p. 36
Pathogenesis of Device-Related Nosocomial Infections	p. 73
Biofilm Resistance-Tolerance to Conventional Antimicrobial Agents	p. 87
Analytical Techniques Useful to Study Biofilms	p. 116
Biofilm-Related Infections in Various Human Organs (Nondevice-Related Chronic Infections)	p. 153
Biofilm-Related Infections in Ophthalmology	p. 155
Biofilm-Related Infections in the Oral Cavity	p. 184
Implications of Biofilm Formation in Chronic Wounds and in Cystic Fibrosis	p. 226
Drug Delivery Carriers to Eradicate Biofilm Formation on Medical Devices	p. 265
Strategies For Prevention of Device-Related Nosocomial Infections	p. 267
Liposomes as Drug Delivery Carriers to Biofilms	p. 337
Polymer-Based Antimicrobial Delivery Carriers	p. 359
Index	p. 418
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