Biofilm Eradication and Prevention : A Pharmaceutical Approach to Medical Device Infections

by Tamilvanan Shunmugaperumal

• ISBN13: 9780470640456
• ISBN10: 0470640456
• Format: eBook
• Copyright: 2010-06-01
• Publisher: Wiley

Summary

Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

Table of Contents

Development and characterization of biofilm

Introduction and Overview of Biofilm

Rationale for biofilm eradication from modern medical devices

Pathogenesis of device-related nosocomial infections

Biofilm resistance/tolerance to conventional antimicrobial agents

Analytical techniques useful to study biofilm

Conventional plate counting

Modern methods

Biofilm-related infections in various human organs (Nondevice-related chronic infections)

Biofilm-related infections in ophthalmology

Biofilm-related infections in oral cavity

Implications of biofilm formation in chronic wound and in cystic fibrosis

Drug delivery carriers to eradicate biofilm formation on medical devices

Strategies for prevention of device-related nosocomial infections

Novel drug delivery carriers

Lipid-and polymer-based drug delivery carriers

Liposomes as drug delivery carriers to biofilms

Liposomes to reduce microbial adhesion/colonisation onto medical devices

Liposomes as drug delivery carriers to biofilm interfaces

Liposomes as drug delivery carriers in intracellular infection

Stealth® liposomes

Polymer-based antimicrobial delivery carriers

Implantable matrices, beads, strut, microparticles, fibrous scaffolds, thermoreversible gels, etc

Surface modified polymeric catheter materials

Conclusion

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