The Biology of Gastric Cancers

by Wang, Timothy C.; Fox, James G.; Giraud, Andrew S.

• ISBN13: 9780387691817
• ISBN10: 0387691812
• Format: Hardcover
• Copyright: 2009-01-30
• Publisher: Springer Verlag

Summary

There have been many impressive advances in our understanding of the pathogenesis of gastric adenocarcinoma, gastric MALT lymphoma, gastrointestinal stromal tumors of the stomach, and gastric carcinoid tumors over the years. The Biology of Gastric Cancers, edited by Dr. Timothy Wang, Dr. James Fox and Dr. Andy Giraud, pays homage to the cutting edge concepts of cancer stem cells, tumor microenvironment, chronic inflammation, and genetic susceptibility to cancer and represents the very first volume devoted to the subject of the basic biology of gastric cancer. With an emphasis on animal models, but also considerable attention to human studies, host genetics and the role of bacterial factors and other environmental factors influencing the pathogenesis of gastric cancer, the topics presented in this book should be of interest to clinicians and investigators interested in gastrointestinal cancer, as well as basic investigators in related areas of cancer research. This body of work will hopefully stimulate clinical and translational studies that will advance early diagnosis and treatment of gastric tumors. Book jacket.

Table of Contents

Foreword	p. v
Preface	p. ix
Contributors	p. xv
Editors' Biographics	p. xix
Overview and Pathology of Gastric Cancer	p. 1
Epidemiology of Gastric Cancer and Helicobacter pylori	p. 25
Diet and Gastric Cancer	p. 59
MALT Lymphoma: Clinicopathologic Features and Molecular Pathogenesis	p. 91
Gastrointestinal Stromal Tumors of Gastric Origin	p. 135
Human Gastric Neuroendocrine Neoplasia: Current Pathologic Status	p. 165
Gastric Neuroendocrine Neoplasia	p. 185
Epstein-Barr Virus and Gastric Cancer	p. 217
Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer	p. 235
Cancer Genetics of Human Gastric Adenocarcinoma	p. 251
Genomic and Proteomic Advances in Gastric Cancer	p. 285
Animal Models of Gastric Carcinoma	p. 323
Insights into the Development of Preneoplastic Metaplasia: Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy	p. 361
Deregulation of E-Cadherin in Precancerous Lesions and Gastric Cancer	p. 377
Role of CagA in Helicobacter pylori Infection and Pathology	p. 389
The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease	p. 403
Host Immunity in the Development of Gastric Preneoplasia	p. 425
Atrophy and Altered Mesenchymal-Epithelial Signaling Preceding Gastric Cancer	p. 449
Genetic Models of Gastric Cancer in the Mouse	p. 483
Prostaglandin and Transforming Growth Factor [beta] Signaling in Gastric Cancer	p. 513
REG Proteins and Other Growth Factors in Gastric Cancer	p. 541
Role of Bone Marrow-Derived Cells in Gastric Adenocarcinoma	p. 561
Stromal Cells and Tumor Microenvironment	p. 587
Future Prospects for Helicobacter pylori Vaccination	p. 601
Index	p. 621
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