Biomarkers of Human Exposure to Pesticides

by Saleh, Mahmoud A.; Blancato, Jerry N.; Nauman, Charles H.

• ISBN13: 9780841227385
• ISBN10: 0841227381
• Format: Hardcover
• Copyright: 1994-05-05
• Publisher: American Chemical Society

Summary

Explores the role of biomarker data in evaluating the impact of human environmental and occupational exposure to pesticides. Focuses on two types of biomarkers: residue analysis of parent compounds or metabolites and end points representing interactions between xenobiotic and endogenous components. Characterizes the molecular basis of various biomarker methods and examines structure-activity relationships. Surveys biomarker measurement methods currently in use and examines methods for biomarker data analysis and applications of these methods to risk assessment.

Table of Contents

Biomonitoring for Pesticide Exposure

Modeling Cytochrome P-450 Mediated Acute Nitrile Toxicity Using Theoretical Linear Solvation Energy Relationships

Changes in Biochemical and Molecular Biological Parameters Induced by Exposure to Dioxin-Type Chemicals

Regulation of Muscarine Receptors as Biomarkers of Exposure to Insecticides

Correlations of Molecular Connectivity Indices with Toxicities of Organic Nitriles

Computer-Aided Molecular Modeling for Development of Biomarkers for Human Exposure to Pesticides

A Biosensor for Monitoring Blood Cholinesterases as a Biomarker of Exposure to Organophosphorus Anticholinesterase Pesticides

Hair as a Target Tissue for Developing a Biological Marker for Precursors to 2,5-Hexanedione

Hemoglobin Adducts of Pesticides

Immunoassay for p-Nitrophenol in Urine

Isolation of Pesticide-Binding Protein from Rat Blood

Body Burden and Nonoccupational Exposure Assessment

Chronic Organophosphorus Exposure: Biomarkers in the Detection of Immune Dysfunction and the Development of Lymphomas

Validation of a Pharmacokinetic Model To Predict Exposure of Ground Boom Mixer-Loader-Applicators to Chlorophenoxyacetic Acid Herbicides: Comparison to Conventional Approaches

Dermal Absorption and Disposition of Formulations of Malathion in Sprague-Dawley Rats and Humans

Physiologically-Based Pharmacokinetic Models: Examples of Their Use in Exposure and Risk Assessment

Prediction of Anticholinesterase Activity and Urinary Metabolites of Isofenphos: Use of a Percutaneous Physiologically-Based Pharmacokinetic-Physiologically Based Pharmacodynamic Model

Analytic Solution of a Linear Physiologically-Based Pharmacokinetic Model Prototype Useful in Risk Assessment

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