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9780321173867

Bioinformatics in the Post-Genomic Era Genome, Transcriptome, Proteome, and Information-Based Medicine

by
  • ISBN13:

    9780321173867

  • ISBN10:

    0321173864

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2004-08-27
  • Publisher: Addison-Wesley Professional

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

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Supplemental Materials

What is included with this book?

Summary

A comprehensive treatment of the role of bioinformatics in the emerging world of molecular medicine, for anyone involved in this new field

Author Biography

Jeff Augen has a 20-year history in information technology and computational biology

Table of Contents

Preface xv
Introduction
Overview
1(1)
Computationally Intense Problems: A Central Theme in Modern Biology
2(4)
Building the Public Infrastructure
6(1)
The Human Genome's Several Layers of Complexity
7(3)
Toward Personalized Medicine
10(1)
Illnesses are Polygenic
11(5)
New Science, New Infrastructure
16(2)
The Proactive Future of Information-Based Medicine
18(5)
Introduction to Bioinformatics
Introduction
23(1)
The Emergence of Bioinformatics
24(3)
The Public Database Infrastructure
27(3)
Building Database Infrastructure for Bioinformatics
30(49)
Traditional Bioinformatic Tools and Algorithms
79(21)
Summary
100(5)
Gene Structure
Introduction
105(2)
The Central Dogma of Molecular Biology
107(1)
The Genetic Code
108(10)
Structure and Content of the Genome
118(14)
Computational Techniques for the Identification of Genomic Features
132(9)
High-Throughput Gene Sequencing
141(4)
Summary
145(4)
Computational Techniques for Sequence Analysis
Introduction
149(1)
Hidden Markov Models
150(6)
Perceptrons and Neural Networks
156(14)
Pattern Discovery, Single Nucleotide Polymorphisms, and Haplotype Identification
170(10)
Summary
180(3)
Transcription
Introduction
183(3)
The Transcriptome
186(6)
Technologies for Transcriptional Profiling
192(8)
Hierarchical Clustering
200(34)
Summary
234(3)
Overview of the Proteome and the Protein Translation Process
Introduction
237(1)
Ribosomal Structure and the Protein Translation Process
238(8)
Special Features of the Eukaryotic-Translation Process
246(9)
Summary
255(4)
Protein Structure Prediction
Introduction
259(2)
Overview of Ab Initio and Database-Driven Approaches
261(2)
Overview of Protein Structure
263(13)
Protein Structure Databases
276(12)
Ab Initio Structure Prediction
288(8)
Predicting Lead---Target Interactions
296(3)
Summary
299(8)
Medical Informatics and Information-Based Medicine
Introduction
307(1)
The Continuous Evolution in Understanding that Leads to Genomic Medicine
308(6)
Electronic Medical Records
314(9)
Grid Computing and Medical Informatics
323(10)
Modeling and Predicting Disease
333(8)
Summary
341(6)
New Themes in Bioinformatics
Introduction
347(1)
Overview of Parallel Computing and Workflow Distribution in Bioinformatics
348(7)
Workflow Computing
355(4)
High-Performance Computing and Systems Biology
359(2)
The Delineation of Metabolic Pathways
361(6)
Systems Biology
367(7)
Summary
374(3)
Further Reading 377(2)
Index 379

Supplemental Materials

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

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