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9781416002468

Textbook of Pediatric Rheumatology

by
  • ISBN13:

    9781416002468

  • ISBN10:

    1416002464

  • Edition: 5th
  • Format: Hardcover
  • Copyright: 2005-08-02
  • Publisher: Saunders
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List Price: $239.00

Summary

Your smallest patients pose big clinical challenges on a daily basis. Textbook of Pediatric Rheumatology, 5th Edition, equips you with the guidance you need to select the best approaches to rheumatologic and non-rheumatologic musculoskeletal disorders found in children and adolescents.

Table of Contents

Contributing Authors
Foreword
Preface
Color Plate Section
BASIC CONCEPTS
Introduction to the Study of Rheumatic Diseases in Children
2(7)
James T. Cassidy
Ross E. Petty
Evolution of Terminology
2(1)
The Rheumatic Diseases of Childhood
3(1)
Emergence of the Specialty of Pediatric Rheumatology
4(1)
Factors that May Modify Rheumatic Diseases in Children
4(1)
Childhood Rheumatic Diseases: Extent of the Problem
5(1)
Advances in Pediatric Rheumatology
6(1)
References
7(2)
Structure and Function
9(10)
Ross E. Petty
James T. Cassidy
Joints
9(1)
Articular Cartilage
9(4)
Synovium
13(1)
Vascular Supply
14(1)
Connective Tissue Structures
15(1)
Skeletal Muscle
15(2)
References
17(2)
The Immune System and the Inflammatory Response
19(45)
Marco Gattorno
Alberto Martini
Innate Immunity
19(7)
Adaptive Immunity
26(22)
The Multifactorial Origin of Autoimmune Diseases
48(2)
Mechanisms of Tissue Injury in Autoimmune-Mediated Diseases
50(9)
The Autonomic Nervous and Endocrine Mediators in Inflammation
59(1)
References
60(4)
Integrative Genomics
64(12)
Robert A. Colbert
David N. Glass
The Genome
64(3)
Monogenic Disease in Pediatric Rheumatology
67(1)
Complex Genetic Traits
67(2)
Pediatric Rheumatic Illnesses as Complex Genetic Traits
69(2)
Functional Genomics
71(3)
Conclusions
74(1)
References
74(2)
Pharmacology and Drug Therapy
76(66)
Ronald M. Laxer
Concepts in Pharmacology
76(1)
Antirheumatic Drugs
77(49)
Acknowledgment
126(1)
References
127(15)
Design, Measurement, and Analysis of Clinical Investigations
142(32)
Edward H. Giannini
Evidence-Based Medicine and Clinical Investigation
142(1)
Definition of Clinical Research
143(1)
General Terminology and Basic Concepts Associated with Clinical Studies
143(1)
Epidemiologic and Behavioral Studies
144(4)
Outcomes and Health Services Research
148(1)
Patient-Oriented Research
149(2)
Considerations for Individual Clinical Trials
151(6)
Understanding and Describing Data
157(4)
Statistical Tests of Inference Commonly Used in Clinical Investigations
161(10)
Judging the Quality of a Report of a Clinical Investigation
171(1)
References
171(3)
Assessment of Health Status, Function, and Quality of Life Outcomes: Methodology and Instruments
174(10)
Claran M. Duffy
Daniel J. Lovell
Background
174(2)
Process of Instrument Development
176(1)
Background on Available Instruments for Childhood Rheumatic Diseases
176(1)
Instruments for Juvenile Rheumatoid Arthritis
177(3)
Instruments Available for Use in Rheumatic Diseases Other than Juvenile Idiopathic Arthritis
180(1)
Conclusion
181(1)
References
181(3)
A General Approach to Management of Rheumatic Diseases in Children
184(22)
Balu H. Athreya
Carol B. Lindsley
Patient Education
185(1)
Counseling
186(1)
Adherence (Compliance)
186(1)
Sibling Issues
186(1)
School Issues
187(1)
Transition
187(1)
Financial Issues
188(1)
Unconventional Remedies
189(1)
Physical and Occupational Therapy
189(10)
Immunization
199(1)
References
200(2)
Appendix 8--1
202(1)
Appendix 8--2
203(3)
CHRONIC ARTHRITIS
Chronic Arthritis in Childhood
206(55)
James T. Cassidy
Ross E. Petty
Historical Review
208(1)
Epidemiology
209(2)
Etiology and Pathogenesis
211(3)
Genetic Background
214(2)
Clinical Manifestations
216(4)
Organ-Specific Manifestations of Chronic Arthritis
220(2)
Pathology
222(1)
Laboratory Examination
223(3)
Radiologic Examination
226(5)
Treatment
231(11)
Course of the Disease and Prognosis
242(2)
Perspective
244(1)
References
245(16)
Polyarthritis
261(13)
Ross E. Petty
James T. Cassidy
Definitions
261(1)
Epidemiology
261(1)
Etiology and Pathogenesis
261(1)
Genetic Background
262(1)
Clinical Manifestations
262(3)
Diagnosis
265(1)
Pathology
266(1)
Laboratory Examination
267(1)
Radiologic Examination
268(1)
Treatment
268(3)
Course of the Disease and Prognosis
271(1)
References
271(3)
Oligoarthritis
274(17)
Ross E. Petty
James T. Cassidy
Definition
274(1)
Epidemiology
274(1)
Genetics
275(2)
Etiology and Pathogenesis
277(1)
Clinical Manifestations
277(1)
Diagnosis
277(1)
Complications: Uveitis
278(5)
Laboratory Evaluation
283(1)
Radiographic Evaluation
283(1)
Management
284(1)
Disease Course and Prognosis
285(1)
Perspective
286(1)
References
287(4)
Systemic Arthritis
291(13)
Ross E. Petty
James T. Cassidy
Definition and Classification
291(1)
Epidemiology
291(1)
Etiology and Pathogenesis
291(1)
Genetic Background
292(1)
Clinical Manifestations
292(5)
Diagnosis and Differential Diagnosis
297(1)
Pathology
298(1)
Laboratory Examination
298(1)
Radiologic Examination
298(1)
Treatment
298(2)
Course of the Disease and Prognosis
300(1)
References
300(4)
Juvenile Ankylosing Spondylitis
304(20)
James T. Cassidy
Ross E. Petty
Definition and Classification
304(3)
Epidemiology
307(1)
Etiology and Pathogenesis
308(1)
Genetic Background
308(1)
Clinical Manifestations
309(2)
Pathology
311(1)
Differential Diagnosis
311(3)
Laboratory Examination
314(1)
Radiologic Examination
315(2)
Treatment
317(2)
Course of the Disease and Prognosis
319(1)
References
320(4)
Psoriatic Arthritis
324(10)
Ross E. Petty
Taunton R. Southwood
Definition and Classification
324(1)
Epidemiology
324(1)
Etiology and Pathogenesis
325(1)
Genetic Background
326(1)
Clinical Manifestations
327(2)
Pathology
329(1)
Laboratory Examination
329(1)
Radiologic Examination
329(1)
Treatment
329(2)
Course of the Disease and Prognosis
331(1)
References
331(3)
Arthropathies of Inflammatory Bowel Disease
334(8)
Carol B. Lindsley
Ronald M. Laxer
Definition and Classification
334(1)
Epidemiology
334(1)
Etiology and Pathogenesis
334(1)
Genetic Background
334(1)
Clinical Manifestations
335(2)
Pathology
337(1)
Diagnosis and Laboratory Examination
337(1)
Radiologic Examination
337(1)
Treatment
337(1)
Course of the Disease and Prognosis
338(1)
References
338(4)
SYSTEMIC CONNECTIVE TISSUE DISEASES
Systemic Lupus Erythematosus
342(50)
Ross E. Petty
Ronald M. Laxer
Historical Review
342(1)
Definition and Classification
342(1)
Epidemiology
343(1)
Genetic Background
344(2)
Etiology and Pathogenesis
346(3)
Clinical Manifestations
349(11)
Pathology
360(7)
Laboratory Examination
367(6)
General Assessment
373(1)
Treatment
374(6)
Management of Specific Aspects of the Disease
380(1)
Course of the Disease and Prognosis
381(1)
Drug-Induced Lupus
382(1)
Perspective
383(1)
References
383(9)
Neonatal Lupus Erythematosus
392(15)
Earl D. Silverman
Dawn Spence
Robert M. Hamilton
Etiology and Pathogenesis
392(2)
Genetic Background
394(1)
Clinical Manifestations of Neonatal Lupus Erythematosus
394(5)
Course of the Disease and Prognosis
399(1)
Animal Models of Neonatal Lupus Erythematosus
400(1)
References
401(6)
Juvenile Dermatomyositis
407(35)
James T. Cassidy
Carol B. Lindsley
Historical Review
407(1)
Epidemiology
407(1)
Etiology and Pathogenesis
408(2)
Genetic Background
410(1)
Clinical Manifestations
411(3)
Pathology
414(6)
Differential Diagnosis
420(4)
Laboratory Examination
424(3)
Radiologic Examination
427(1)
Treatment
428(4)
Course of the Disease and Prognosis
432(2)
References
434(8)
The Systemic Sclerodermas and Related Disorders
442(28)
Francesco Zulian
James T. Cassidy
Definition and Classification
442(1)
Historical Review
442(1)
Diffuse Cutaneous Systemic Scleroderma
442(21)
Limited Cutaneous Systemic Scleroderma
463(2)
References
465(5)
Localized Sclerodermas
470(12)
Audrey M. Nelson
Ronald M. Laxer
Definition and Classification
472(2)
Epidemiology
474(1)
Etiology and Pathogenesis
475(1)
Clinical Manifestations
475(1)
Pathology
476(1)
Differential Diagnosis
477(1)
Laboratory Examination
477(1)
Treatment
478(1)
Course of the Disease and Prognosis
478(1)
References
479(3)
Overlap Syndromes
482(10)
James T. Cassidy
Ross E. Petty
Mixed Connective Tissue Disease
482(4)
Sjogren's Syndrome
486(2)
References
488(4)
SYSTEMIC VASCULITIS
Vasculitis and Its Classification
492(4)
James T. Cassidy
Ross E. Petty
Classification
492(1)
General Clinical Aspects of Vasculitis
492(1)
Epidemiology
492(3)
References
495(1)
Leukocytoclastic Vasculitis
496(16)
James T. Cassidy
Ross E. Petty
Henoch-Schonlein Purpura
496(5)
Hypersensitivity Angiitis
501(2)
Hypocomplementemic Urticarial Vasculitis
503(1)
Mixed Cryoglobulinemia
504(1)
Other Leukocytoclastic and Perivasculitic Syndromes and Similar Disorders
504(3)
References
507(5)
Polyarteritis Nodosa and Related Vasculitides
512(9)
James T. Cassidy
Ross E. Petty
Polyarteritis Nodosa
512(5)
Cutaneous Polyarteritis
517(1)
Other Rare Vasculitides
518(1)
References
518(3)
Kawasaki Disease
521(18)
Robert P. Sundel
Ross E. Petty
Historical Background
521(1)
Definition and Diagnostic Criteria
521(1)
Epidemiology
521(1)
Etiology and Pathogenesis
522(1)
Genetic Background
523(1)
Clinical Manifestations
523(6)
Differential Diagnosis
529(1)
Pathology
529(1)
Laboratory Examination
529(1)
Treatment
530(4)
Treatment of Relapses
534(1)
Follow-up and Monitoring of Cardiac Status
534(2)
Disease Course and Prognosis
536(1)
Perspective
536(1)
References
536(3)
Granulomatous Vasculitis, Giant Cell Arteritis and Sarcoidosis
539(22)
Carol B. Lindsley
Ronald M. Laxer
Wegener's Granulomatosis
539(9)
Giant Cell Arteritis
548(3)
Sarcoidosis
551(5)
References
556(5)
Behcet's Disease
561(7)
Seza Ozen
Ross E. Petty
Definition and Classification
561(1)
Epidemiology
561(1)
Genetic Background
561(1)
Etiology and Pathogenesis
562(1)
Clinical Manifestations
562(2)
Pathology
564(1)
Laboratory Examination
564(1)
Imaging Studies
564(1)
Diagnosis
564(1)
Treatment
565(1)
Course of the Disease and Prognosis
565(1)
References
565(3)
ARTHRITIS RELATED TO INFECTION
Infectious Arthritis and Osteomyelitis
568(23)
Ross E. Petty
Ronald M. Laxer
Septic Arthritis
568(8)
Osteomyelitis
576(4)
Arthritis Caused by Viruses
580(4)
Arthritis Associated with Other Infections
584(1)
Postinfectious Arthritis
585(1)
References
585(6)
Lyme Disease
591(13)
Hans-Iko Huppertz
Frank Dressler
Definition and Classification
591(1)
Epidemiology
591(1)
Genetic Background
592(1)
Etiology and Pathogenesis
592(1)
Clinical Manifestations
593(2)
Pathology
595(1)
Laboratory Examination
595(2)
Diagnosis
597(1)
Treatment
598(2)
Course of the Disease and Prognosis
600(1)
References
600(4)
Reactive Arthritis
604(10)
Ruben Burgos-Vargas
Janitzia Vazquez-Mellado
Definition
604(1)
Classification and Diagnostic Criteria
604(1)
Epidemiology
604(1)
Genetic Background
605(1)
Etiology and Pathogenesis
605(1)
Clinical Manifestations
606(3)
Laboratory Examination
609(1)
Radiologic Examination
609(1)
Differential Diagnosis
610(1)
Treatment
610(1)
Course of the Disease and Prognosis
611(1)
References
612(2)
Acute Rheumatic Fever and Post-streptocococcal Reactive Arthritis
614(16)
Ella M. Ayoub
Khaled Alsaeld
Acute Rheumatic Fever
614(10)
Post-Streptococcal Reactive Arthritis
624(2)
Acknowledgment
626(1)
References
626(4)
Musculoskeletal Manifestations of Systemic Disease
630(12)
James T. Cassidy
Ross E. Petty
Nutritional Abnormalities
630(3)
Metabolic Diseases
633(2)
Hematologic Disorders
635(1)
Disorders of Endocrine and Exocrine Glands
636(1)
Cystic Fibrosis
637(1)
Hyperostosis
638(1)
Pancreatitis with Arthritis
638(1)
Sphingolipidoses
638(1)
References
639(3)
Immunodeficiencies and the Rheumatic Diseases
642(15)
Nico M. Wulffraat
Lieke A.M. Sanders
Wletse Kuis
Disorders of Innate Immunity Associated with Rheumatic Diseases
642(4)
Disorders of Adaptive Immunity Associated with Diseases
646(8)
References
654(3)
Periodic Fever Syndromes in Children
657(14)
Susannah Brydges
Balu Athreya
Daniel L. Kastner
Infectious Causes of Periodic Fever Syndromes
657(1)
Rheumatic Disorders
658(1)
Hereditary Periodic (Recurrent) Fever Syndromes
658(9)
References
667(4)
Cryopyrin-Associated Periodic Syndromes
671(5)
Benedicte Neven
Anne-Marie Prieur
Ross E. Petty
Genetics and Etiology
672(1)
Clinical Manifestations
672(2)
Treatment
674(1)
References
674(2)
Noninflammatory Musculoskeletal Pain Conditions
676(21)
Peter N. Malleson
David D. Sherry
Pain Associated with Hypermobility
676(4)
Pain Syndromes Related to Overuse
680(3)
Osteochondroses
683(3)
Trauma-Induced Conditions
686(3)
Pain Syndromes Affecting the Back, Chest, or Neck
689(3)
Miscellaneous Conditions
692(2)
References
694(3)
Pain and the Pain Amplification Syndromes
697(19)
David D. Sherry
Peter N. Malleson
Anatomy, Physiology, and Measurement of Pain
697(1)
Nociceptive Mechanisms
697(1)
Modulating (Sensitizing and Inhibiting) Mechanisms
698(2)
The Child in Pain
700(1)
Evaluation and Management of Musculoskeletal Pain
700(3)
Pain Management
703(1)
Historical Review
703(1)
Definition and Classification
703(1)
Epidemiology
704(1)
Etiology and Pathogenesis
704(2)
Genetic Background
706(1)
Clinical Manifestations
706(1)
Pathology
707(1)
Differential Diagnosis
707(1)
General Assessment of Pain
708(1)
Laboratory Examination
708(1)
Radiographic Examination
709(1)
Treatment
709(1)
Course and Prognosis
710(1)
Conclusion
710(1)
References
710(6)
PRIMARY AND ACQUIRED DISORDERS OF BONE AND CONNECTIVE TISSUE
Skeletal Maturation and Bone Mineralization in the Pediatric Rheumatic Diseases
716(12)
Rolando Cimaz
Fernanda Falcini
Normal Skeletal Maturation
716(3)
Diagnostic Methods
719(2)
Bone Mineralization in the Rheumatic Diseases
721(1)
Primary and Secondary Bone Mineralization Disorders
722(1)
Prevention
722(1)
Treatment
723(2)
References
725(3)
Skeletal Malignancies and Related Disorders
728(16)
James T. Cassidy
Ross E. Petty
Primary Tumors of Bone, Cartilage, Fibrous or Soft Tissue, or Miscellaneous Origin
728(8)
Malignant Tumors
736(3)
Metastatic Bone Tumors
739(1)
Malignant Infiltration of Bone Marrow: Leukemia
739(2)
Secondary Effects of Malignancy
741(1)
Acknowledgment
741(1)
References
742(2)
Primary Disorders of Bone and Connective Tissues
744(23)
Carol B. Lindsley
Ross E. Petty
Judith G. Hall
Establishing a Diagnosis
744(1)
Molecular Mechanisms of Disease
745(1)
Common Clinical Concerns
745(1)
Osteochondrodysplasias
746(10)
Marfan Syndrome and Similar Disorders
756(1)
Dysostosis Multiplex
757(2)
Other Disorders
759(3)
References
762(5)
Subject Index 767

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