Cancer Chemotherapy

by Barton-Burke, Margaret; Wilkes, Gail M.; Ingwersen, Karen C.; Bean, Catherine K.; Berg, Deborah

• ISBN13: 9780867207187
• ISBN10: 0867207183
• Edition: 2nd
• Format: Hardcover
• Copyright: 1996-04-01
• Publisher: Jones & Bartlett Learning

Summary

Oncology Consulting Services, Boston, MA. Second edition of a clinical reference for practitioners. Previous edition 1991. Emphasizes the nursing process, including diagnosis and care plans. Concise format. Extensive use of charts. 13 U.S. contributors. DNLM: Neoplasms - nursing.

Table of Contents

Preface to the Second Edition	xi
Preface to the First Edition	xiii
Acknowledgments	xv
Contributors	xvii
PART I From the Advent of Chemotherapy to Current Research: The Cancer Nurse's Role
Oncology Nursing Practice: The Role of the Nurse in Support of Progress in Cancer Treatment	3	(18)
Jean F. Jenkins
Evolution of Oncology Nursing	3	(1)
Unique Role of the Nurse in Cancer Chemotherapy	4	(3)
Unique Role of the Nurse in Cancer Research	7	(1)
The Development of the National Cancer Institute and Anticancer Drug Research	7	(1)
Clinical Trials	8	(1)
The Phases of Clinical Trials	9	(3)
Ethical Issues in Clinical Research	12	(2)
The Roles of Nurses in Clinical Oncology	14	(3)
Conclusion	17	(1)
Bibliography	18	(3)
Cell Cycle Kinetics and Antineoplastic Agents	21	(22)
Karen C. Ingwersen
History of Cancer Therapy	21	(2)
Advent of Cancer Chemotherapy	23	(2)
The Cell Cycle and Its Importance	25	(2)
Cell Cycle Phase-Specific Agents	27	(1)
Cell Cycle Phase-Nonspecific Agents	28	(1)
Chemotherapy and Cell Kinetics	28	(2)
Classification of Antineoplastic Agents	30	(5)
Rationale of Single-Agent Therapy versus Combination Therapy	35	(3)
Mechanisms of Drug Resistance	38	(1)
Conclusion	39	(2)
Bibliography	41	(2)
Biotherapy: The Fourth Modality	43	(32)
Paula Trahan Rieger
Historical Perspective	43	(4)
Definition of Terms	47	(1)
Classification	48	(1)
Agents	49	(10)
Combination Therapies	59	(2)
Nursing Implications	61	(2)
Conclusion	63	(6)
Bibliography	69	(6)
New Frontiers of Chemotherapy	75	(22)
Cynthia R. King
Introduction	75	(1)
Marrow/Stem Cell Transplantation	75	(10)
Colony-Stimulating Factors	85	(3)
Multidrug Resistance	88	(2)
Chemoprevention	90	(2)
Toxins	92	(1)
Conclusion	92	(1)
Bibliography	92	(5)
PART II Cancer Chemotherapy: Mechanisms and Nursing Care
Potential Toxicities and Nursing Management	97	(90)
Gail M. Wilkes
Introduction	97	(1)
Toxicity to Rapidly Proliferating Normal Cell Populations	98	(40)
Bone Marrow Depression (BMD)	98	(18)
Mucositis	116	(14)
Alopecia	130	(4)
Gonadal Dysfunction	134	(4)
Nausea and Vomiting	138	(15)
Antiemetic Treatment	144	(4)
Pharmacology of Antiemetics	148	(4)
Extrapyramidal Side Effects: Assessment and Intervention	152	(1)
Toxicity to Other Organ Systems	153	(34)
Introduction	153	(1)
Cardiotoxicity of Antineoplastic Drugs	153	(5)
Pulmonary Toxicity	158	(3)
Hepatotoxicity	161	(1)
Nephrotoxicity	161	(8)
Neurotoxicity	169	(11)
Bibliography	180	(7)
Chemotherapeutic Agents: Standardized Nursing Care Plans to Minimize Toxicity	187	(282)
Introduction	187	(1)
Acridinyl anisidide	188	(4)
Adrenocorticoids	192	(4)
Aminoglutethimide	196	(4)
Androgens	200	(3)
5-Azacytidine	203	(3)
Aziridinylbenzaquinone	206	(4)
Bleomycin sulfate	210	(6)
Busulfan	216	(2)
Camptothecin-11	218	(3)
Carboplatin	221	(4)
Carmustine	225	(4)
Chlorambucil	229	(4)
Cisplatin	233	(5)
Cladribine	238	(5)
Cyclophosphamide	243	(5)
Cytarabine, cytosine arabinoside	248	(4)
Dacarbazine	252	(6)
Dactinomycin	258	(5)
Daunorubicin hydrochloride	263	(5)
Dihydro-5-Azacytidine	268	(2)
Doxorubicin hydrochloride	270	(5)
Estramustine phosphate	275	(5)
Estrogens	280	(4)
Etoposide	284	(6)
Floxuridine	290	(5)
Fludarabine phosphate	295	(3)
5-Fluorouracil	298	(4)
Flutamide	302	(2)
Gallium nitrate	304	(2)
Gemcitabine	306	(3)
Hexamethylmelamine	309	(3)
Hydroxyurea	312	(4)
Idarubicin	316	(5)
Ifosfamide	321	(5)
L-asparaginase	326	(5)
Leucovorin calcium	331	(2)
Leuprolide acetate	333	(3)
Levamisole hydrochloride	336	(4)
Lomustine	340	(4)
Mechlorethamine hydrochloride	344	(7)
Melphalan	351	(5)
6-Mercaptopurine	356	(3)
Mesna	359	(2)
Methotrexate	361	(5)
Methyl-CCNU	366	(3)
Misonidazole	369	(2)
Mitoguazone dihydrochloride	371	(6)
Mitomycin	377	(5)
Mitotane	382	(3)
Mitoxantrone	385	(5)
Oxaliplatin	390	(3)
Paclitaxel	393	(6)
Pala	399	(3)
Pentostatin	402	(4)
Plicamycin	406	(4)
Procarbazine hydrochlorozide	410	(4)
Progestational agents	414	(2)
Streptozocin	416	(4)
Suramin sodium	420	(4)
Tamoxifen citrate	424	(3)
Taxotere	427	(4)
Teniposide	431	(5)
6-Thioguanine	436	(3)
Thiotepa	439	(3)
Trimetrexate	442	(3)
Vinblastine	445	(5)
Vincristine	450	(5)
Vindesine	455	(5)
Vinorelbine	460	(5)
Bibliography	465	(4)
Drug Interactions with Cancer Chemotherapy	469	(22)
Reginald S. King
Introduction	469	(1)
Pharmacokinetic Interactions	470	(5)
Pharmacodynamic Interactions	475	(3)
Miscellaneous	478	(1)
Conclusion	478	(9)
Bibliography	487	(4)
PART III Clinical Application
Care of the Pediatric Oncology Patient	491	(28)
Sue P. Heiney
Linda M. Wells
Introduction	491	(1)
History of Pediatric Oncology	491	(2)
Major Types of Childhood Cancers and Treatment	493	(2)
Care Plans	495	(22)
Bibliography	517	(2)
Chemotherapy in the Elderly: Considerations for Clinical Practice	519	(16)
Constance Engelking
Introduction	519	(1)
Barriers to Treatment	520	(9)
Age-Related Drug Toxicities	529	(2)
Nursing Considerations	531	(2)
Bibliography	533	(2)
Principles of Chemotherapy Administration	535	(26)
Deborah Berg
Introduction	535	(1)
Chemotherapy Checklist	536	(1)
Issues in Chemotherapy Administration in Ambulatory and Home Settings	537	(1)
Nursing Assessment: Prechemotherapy and Postchemotherapy	538	(1)
Reactions: Extravasation, Hypersensitivity, and Anaphylaxis	539	(19)
Bibliography	558	(3)
Drug Delivery Systems	561	(36)
Deborah Berg
Introduction	561	(1)
Routes of Administration	561	(6)
Intravenous Administration	567	(5)
Controversial Issues in Chemotherapy Administration	572	(1)
Dose Calculations and Modifications	572	(3)
Drug Interactions	575	(1)
Drug Delivery Systems	576	(16)
Conclusion	592	(2)
Bibliography	594	(3)
The Safe Handling of Cancer Chemotherapeutic Agents	597	(120)
Catherine K. Bean
Introduction	597	(1)
Historical Perspective of Cytotoxic Agents	598	(2)
Review of the Literature	600	(1)
Risk of Exposure	601	(1)
Recommended Guidelines for Safe Handling	601	(4)
Translating Guidelines into Practice	605	(1)
Safe Handling Practices in the Community	606	(5)
Conclusion	611	(1)
Bibliography	611	(5)
Appendices
Appendix 1: National Cancer Institute's Common Toxicity Criteria	616	(4)
Appendix 2: Chemotherapeutic Acronyms	620	(3)
Appendix 3: Controlling Occupational Exposure to Hazardous Drugs: OSHA Guidelines	623	(23)
Appendix 4: Cancer Chemotherapeutic Agents Compatibility Chart	646	(31)
Appendix 5: Nomograms for Determination of Body Surface Area from Height and Weight (Adults)	677	(1)
Appendix 6: Table of Standard Body Weights (Pounds--Kilograms)	678	(1)
Appendix 7: Nomograms for Determination of Body Surface Area from Height and Weight (Children)	679	(1)
Appendix 8: Examples of Pediatric Resources	680	(2)
Appendix 9: Yellow Pages for Cancer Chemotherapy	682	(35)
Index	717