Cardiac Repolarization

by Gussak, Ihor; Antzelevitch, Charles; Hammill, Stephen C.; Shen, Win K.; Bjerregaard, Preben

• ISBN13: 9781588290694
• ISBN10: 1588290697
• Format: Hardcover
• Copyright: 2003-03-01
• Publisher: Humana Pr Inc

Summary

A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Table of Contents

Dedication	v
Foreword	vii
Preface	ix
Contributors	xv
Part I. Introduction
Ventricular Repolarization and the Identification of the Sudden Death Candidate: Hype or Hope?	3	(4)
Hein J. Wellens
Douglas P. Zipes
Historical Milestones of Electrical Signal Recording and Analysis	7	(18)
Thorsten Lewalter
Berndt Luderitz
Part II. Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization
Charles Antzelevitch
Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization	25	(38)
Jeanne M. Nerbonne
Robert S. Kass
Electrophysiology and Pharmacology of Ventricular Repolarization	63	(28)
Charles Antzelevitch
Andrew C. Zygmunt
Robert Dumaine
How Do We Measure Repolarization Inside the Heart?	91	(20)
Charles Antzelevitch
Andrew C. Zygmunt
Jeffrey Fish
Guillermo Perez
Fabiana Scornik
Contribution of Electrical Heterogeneity of Repolarization to the ECG	111	(16)
Charles Antzelevitch
Vladislav V. Nesterenko
Electrical and Structural Remodeling of the Ventricular Myocardium in Disease	127	(26)
Antonis A. Armoundas
Gordon F. Tomaselli
Ischemia-Related Changes in Repolarization	153	(16)
Andre G. Kleber
Michiel J. Janse
The Long QT Syndrome: Molecular and Genetic Aspects	169	(18)
Carlo Napolitano
Silvia G. Priori
Ion Channel Disease as a Cause of the Brugada Syndrome: Molecular and Genetic Aspects	187	(14)
Connie R. Bezzina
Arthur A. M. Wilde
Cellular and Ionic Mechanisms Underlying Arrhythmogenesis	201	(54)
Charles Antzelevitch
Alexander Burashnikov
Jose M. Di Diego
Part III. Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice
Stephen C. Hammill
Win-Kuang Shen
Ihor Gussak
Evaluation of Ventricular Repolarization: The Clinician's Perspective	255	(36)
Jan Nemec
Stephen C. Hammill
Win-Kuang Shen
Human Cardiac Repolarization	291	(20)
Philip T. Sager
QT Interval and Its Drug-Induced Prolongation	311	(18)
Wojciech Zareba
Arthur J. Moss
Neuro-Mediated Repolarization Abnormalities	329	(22)
Philippe Coumel
Pierre Maison-Blanche
The Electrophysiologic Matrix: Equilibrium and Arnsdorf's Paradox	351	(36)
Morton F. Arnsdorf
Antiarrhythmic Drugs and Future Direction	387	(20)
Arshad Jahangir
Andre Terzic
Win-Kuang Shen
Part IV. Specific Electrocardiographic Phenomena and Clinical Syndromes of Ventricular Repolarization
Ihor Gussak
Charles Antzelevitch
Preben Bjerregaard
ECG Phenomena of the Early Ventricular Repolarization: Early Repolarization Syndrome	407	(20)
Ihor Gussak
Charles Antzelevitch
Preben Bjerregaard
The Brugada Syndrome	427	(20)
Pedro Brugada
Ramon Brugada
Charles Antzelevitch
Koonlawee Nademanee
Jeffrey Towbin
Josep Brugada
Clinical Evaluation, Risk Stratification, and Management of Congenital Long QT Syndrome	447	(34)
Anant Khositseth
Michael J. Ackerman
Prolonged Repolarization and Sudden Infant Death Syndrome	481	(16)
Peter J. Schwartz
Short QT Interval: ECG Phenomenon and Clinical Syndrome	497	(10)
Ihor Gussak
Charles Antzelevitch
Daniel Goodman
Preben Bjerregaard
T-Wave Alternans: Mechanisms, Relevance, and Clinical Implications	507	(24)
Etienne Pruvot
David S. Rosenbaum
Index	531