Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms

by Editor: Michael Artman (University of Iowa College of Medicine); Editor: D. Woodrow Benson (Children's Hospital Medical Center, Cincinnati); Editor: Deepak Srivastava (University of Texas); Editor: Makoto Nakazawa (The Heart Insititute of Japan,

• ISBN13: 9781405143912
• ISBN10: 1405143916
• Format: eBook
• Copyright: 2008-04-01
• Publisher: Wiley-Blackwell

Summary

Congenital cardiovascular malformations are the single most common form of birth defect. Therefore a better understanding of the mechanisms involved in both normal cardiac development and the formation of cardiovascular structural defects is of tremendous importance. This book brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases. A broad variety of approaches, techniques, experimental models and studies of human genetics combine to make this a truly outstanding and unique treatise on this pressing topic. Cardiovascular Development and Congenital Malformations is divided into distinct categories, each focusing on a particular aspect of cardiovascular development. Sections are accompanied by editorial overviews which integrate new findings and place the information into a broader context.

Table of Contents

Establishing Left-Right Patterning and Cardiac Looping

Microenvironment provides leftûright instructions to migrating precardiac mesoderm

Calmodulin- inv protein interaction and left-right determination

Misexpression of upstream laterality genes on downstream mechanisms of heart looping: A flectin perspective

Pleiotropic effects of Pitx2 isoform c on morphogenesis in the mammalian heart

Signal transductions during cardiac myofibrillogenesis and looping

Biological role of fibulin-2 in cardiovascular development

Mechanisms of Cardiogenesis and Myocardial Development

TBX5 regulates cardiac cell behavior during cardiogenesis

Cardiac homeobox protein Csx/Nkx2-5and its associated proteins

Regulation of myocardium formation after the initial development of the linear heart tube

The Role of the extracellular matrix (ECM) in cardiac development

Teratogenic effects of bis-diamine on the developing myocardium

Proliferative responses to myocardial remodeling in the developing heart

Formation of Endocardial Cushions and Valves

TGFâ signaling during atrioventricular cushion transformation

The endocardium as a unique modulator of in utero cardiovascular form and function

Valvulogenesis: Role of periostin in cushion tissue differentiation

Role of Fibroblast growth factors in early valve leaflet formation

Msx1 expression during chick heart development: possible role in endothelial-mesenchymal transformation during cushion tissue formation

Segment and Chamber Specification

Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis

Transciptional regulation of ventricular morphogenesis

Fgf10 and the embryological origin of outflow tract myocardium

Evolutionary conservation of atrial natriuretic factor (Anf) expression, cardiac chamber formation and the heart-forming region

Formation of Specialized Conduction Tissues

Induction and Patterning of the Impulse Conducting Purkinje Fiber Network

Spatial Correlation of Conduction Tissue in the Ventricular Trabeculae of the Developing Zebrafish

Development of the cardiac conduction system and contribution of neural crest and epicardially derived cells

The Development of the Cardiac Conduction System: an old story with a new perspective

The role of calreticulin in cardiac development and function

Coronary Artery Development

Development of proximal coronary artery in quail embryonic heart

Possible roles of the extracellular matrix in coronary vasculogenesis of mouse

Abnormal coronary development in bis-diamine treated embryo

Models of Congenital Cardiovascular Malformations

Deciphering the basis for congenital heart defects using a mouse model of Holt-Oram syndrome

The role of the transcriptional co-repressor FOG-2 in cardiac development

Molecular mechanisms regulating tissue-specific expression of Tbx1

Tbx1 and DiGeorge syndrome: A genetic link between cardiovascular and pharyngeal development

New insights into the role of Tbx1 in the DiGeorge mouse model

Role of Neural Crest Cells in Cardiovascular Development

Sdf1/CxcR4 chemotaxisis is disrupted within the splotch mouse mutant cardiovascular system

Differences in migration and differentiation capacities OF early- and late-migrating cardiac neural crest cells

TGF2 does not affect neural crest cell migration but is a keyplayer in vascular remodelling during embryogenesis

Neural Crest Cells Contribute to Heart Formation and Cardiomyogenesis in Zebrafish

Formation of Outflow Tracts

Outflow tract remodelling û a role for tissue polarity?

Hdf-affected gene fragment revealed by subtraction study of Hdf

Imaging Techniques

Imaging of heart development in embryos with magnetic resonance microscopy

Cardiovascular Physiology During Development

Shear stress in the developing cardiovascular system

Quantitative analysis for strech-induced cytoskeletal remodeling in endothelial cells

Differential effects of cyclic stretch on embryonic ventricular cardiomyocyte and non-cardiomyocyte orientation

Physiology and biomechanics of developing cardiovascular systems: Expanding frontiers

Three-dimensional fiber architecture of the embryonic left ventricle during normal development and reduced mechanical load

Changes in cardiac excitation-contraction coupling during mammalian development: Implications for regulation of contractile function

Role of the sodium-calcium exchanger (Ncx- within Splotch (Sp2H) myocardial failure

Sarcolipin, a novel regulator of calcium cycling, is preferentially expressed in the murine and human atrium

Developmental apects of cardiac sensitivity to oxygen deprivation: protective mechanisms in the immature heart

Patent Ductus Arteriosus

A comprehensive model for O2 constriction in the human ductus arteriosus

Pharmacological Manipulation of the Fetal Ductus Arteriosus in the Rat

Constriction of Ductus Arteriosus by Selective Inhibition of Cyclooxygenase-1 and -2

Synergistic Constriction of Ductus Arteriosus by Indomethacin and Dexamethasone in Fetal Rats

Human Clinical Genetics and Epidemiology

Prevalence of Congenital Heart Diseases in the Czech Republic

Gene-Environment Interactions in Congenital Heart Disease: An Epidemiological Perspective

Familial Recurrence Risks of Congenital Heart Defects

T-box Gene Family and Congenital Cardiovascular Anomalies

Deciphering the Genetic Etiology of Conotruncal Defects

Cardiovascular Anomalies in Patients with Deletion 22q11.2: A Multi-center Study in Korea

Atrioventricular Canal Defect: Anatomical and Genetic Characteristics

A genetic approach to hypoplastic left heart syndrome

Char syndrome and TFAP2B mutations

The genetic origin of atrioventricular conduction disturbance in humans

Noonan Syndrome and PTPN11 Mutations

Missense Mutations in the PTPN11 as a Cause of Cardiac Defects associated with Noonan Syndrome

Novel Gene Mutations in Patients with Left Ventricular Noncompaction and Evidence for Genetic Heterogeneity

Mitochondrial 16189 DNA Variant and Left Ventricular Hypertrophy in Diabetes Mellitus

Mutation analysis of BMPR2 and other genes in Japanese patients with pediatric primary pulmonary hypertension

Pathophysiology of Williams syndrome arteriopathy

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