Cardiovascular Genomics

by Raizada, Mohan K.; Paton, Julian F. R., Ph.D.; Kasparov, Sergey, M.D., Ph.D.

• ISBN13: 9781588294005
• ISBN10: 1588294005
• Edition: CD
• Format: Hardcover
• Copyright: 2005-02-01
• Publisher: Humana Pr Inc

Summary

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Table of Contents

Preface	v
Contributors	ix
Value-Added PDA	xiii
PART I. GENES AND POLYMORPHISMS IN CARDIOVASCULAR DISEASE
1 Angiotensin II Receptor Polymorphisms and Hypertension	3	(16)
Bruno Baudin
2 Angiotensinogen Gene Polymorphisms and Hypertension	19	(22)
Ashok Kumar
3 Substitution Mapping: Using Congenic Strains to Detect Genes Controlling Blood Pressure	41	(18)
Bina Joe and Michael R. Garrett
4 Local Production of Angiotensinogen: Insights From Genetic Manipulation of Mice	59	(12)
Kamal Rahmouni and Curt D. Sigmund
5 Cardiovascular Pharmacogenomics	71	(24)
Julie A. Johnson and Larisa H. Cavallari
6 Genetic Polymorphisms and Response to HMG-CoA Reductase Inhibitors	95	(20)
Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, and Anthonius de Boer
7 Monogenic Causes of Heart Failure: Familial Dilated Cardiomyopathy	115	(22)
Hideko Kasahara
PART II. GENE TRANSFER FOR COMBATING CARDIOVASCULAR DISEASE
8 Gene Therapy vs Pharmacotherapy	137	(20)
Ryuichi Morishita
9 Molecular Therapeutic Approaches for Myocardial Protection	157	(18)
Alok S. Pachori, Luis G. Melo, and Victor J. Dzau
10 Gene Transfer and the Cardiovascular System	175	(22)
William H. Miller, Stuart A. Nicklin, Andrew H. Baker, and Anna F. Dominiczak
11 Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroke	197	(16)
Julie Chao and Lee Chao
12 Current and Future Novel Targets of Gene Therapy for Hypertension	213	(34)
Michael J. Katovich, Justin L. Grobe, and Mohan K. Raizada
13 Application of Viral Gene Transfer in Studies of Neurogenic Hypertension	247	(22)
Sergey Kasparov, A.G. Teschemacher, and Julian F.R. Paton
14 Vigilant Vectors: Intelligent Gene Vectors for Cardioprotection in Myocardial Ischemia	269	(16)
M. Ian Phillips and Yi Tang
15 Gene Therapy for Cerebral Arterial Diseases	285	(20)
Yoshimasa Watanabe and Donald D. Heistad
PART III. REGENERATIVE TISSUES FOR THE DISEASED CARDIOVASCULAR SYSTEM
16 Therapeutic Angiogenesis and Vasculogenesis for Tissue Regeneration	305	(20)
Paolo Madeddu
17 Cell Transplantation: The New Frontier	325	(20)
Shafie Fazel, Paul W.M. Fedak, Richard D. Weisel, Denis Angoulvant, Terrence M. Yau, and Ren-Ke Li
18 Embryonic Stem Cells and the Cardiovascular System	345	(10)
Neta Lavon and Nissim Benvenisty
Index	355