Casebook in Clinical Pharmacokinetics and Drug Dosing

by Cohen, Henry

• ISBN13: 9780071628358
• ISBN10: 0071628355
• Edition: 1st
• Format: Paperback
• Copyright: 2015-01-07
• Publisher: McGraw-Hill Education / Medical

Summary

A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS

Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes.

Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including:

• Indications
• Mec hanisms of action
• Toxicities
• Pharmacokinetics

There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.

Table of Contents

1. Amiodarone & Dronedarone

2. Aminoglycosides

3. Antibiotics Continuous Infusions and Intermittent Infusions

4. Antiepileptic Drugs: Second Generation/Newer Agents

5. Carbamazepine

6. Cyclosporine

7. Digoxin

8. Ethosuximide

9. Lidocaine

10. Lithium

11. Depot Antipsychotics

12. Methotrexate

13. Phenobarbital & Primidone

14. Phenytoin & Fosphenytoin

15. Polymyxin & Colistin

16. Procainamide

17. Quinidine

18. Sirolimus and Tacrolimus

19. Theophylline

20. Valproic Acid

21. Vancomycin

22. Warfarin

23. Heparin and LMWH

24. DTIs oral and IV

25. Toxicokinetics

26. Dialysis

27. P-Glycoprotein Transporter Interactions

28. CYP-450 Interactions

29. Glucuronidation Interactions